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Lactobacillus Acidophilus Rsb12

Also known as: Acidophilus, L. acidophilus, *Lactobacillus acidophilus*

Overview

*Lactobacillus acidophilus* is a lactic acid-producing probiotic bacterium commonly found in the human gut and fermented foods such as yogurt and kefir. It plays a significant role in maintaining gut health, managing gastrointestinal symptoms, and potentially enhancing immune function. Characterized by its ability to ferment sugars into lactic acid, it helps maintain an optimal gut environment. While there is a substantial body of research regarding its effects, results can vary, indicating a need for further studies to draw more definitive conclusions about its health benefits. The current evidence shows promise, primarily through systematic reviews and meta-analyses, but highlights the variability in quality and outcomes across studies.

Benefits

1. **Cholesterol Reduction**: Meta-analyses indicate that *L. acidophilus* can effectively lower total cholesterol and LDL-C levels, with reductions averaging -0.17 mmol/L for total cholesterol and -0.22 mmol/L for LDL-C (high-quality evidence). 2. **Gastrointestinal Health**: There is mixed evidence regarding its use for acute gastroenteritis in children; while some studies suggest a reduction in diarrhea duration, it is often not statistically significant (moderate-quality evidence). 3. **Glycemic Control**: Supplementation has shown potential benefits in reducing fasting plasma glucose, particularly in overweight adults (moderate-quality evidence). The most pronounced benefits appear in children with acute gastrointestinal issues when high doses are administered. Over time, prolonged administration is linked to enhanced effects for both cholesterol management and digestive health.

How it works

*Lactobacillus acidophilus* exerts its effects primarily by modulating gut microbiota and producing lactic acid, which lowers pH and helps suppress pathogenic bacteria. This strain interacts with the immune system, potentially enhancing immune responses, and is thought to influence health through the gut-brain axis. It acts locally rather than being absorbed into the bloodstream, indicating its importance in maintaining gut homeostasis rather than systemic effects.

Side effects

The safety profile of *Lactobacillus acidophilus* indicates that it is generally well-tolerated, with mild gastrointestinal symptoms such as bloating and gas reported in over 5% of users. No consistently reported side effects occur in 1-5% of cases. Rarely, it may lead to systemic infections in severely immunocompromised individuals. Drug interactions are usually minimal, but concerns exist with immunosuppressants and antibiotics, as they could alter the probiotic's efficacy. Special caution is advised for critically ill patients or individuals with compromised gut integrity, as the probiotic may not be suitable in these cases.

Dosage

The effective minimum dose for gastrointestinal benefits is ≥10^9 CFU. Optimal daily dosages typically range between 1 to 10 billion CFU. Although the upper limits of safe dosage are not firmly established, the standard range is generally regarded as safe. It is recommended to take probiotics with food to enhance survival through stomach acid. Common formulations include capsules and powders, and conditions like food interaction can improve absorption rates. Factors affecting survival are critical in determining efficacy.

FAQs

Is *Lactobacillus acidophilus* safe for everyone?

Generally safe for most, but caution is advised for immunocompromised individuals or critically ill patients.

When should I take *Lactobacillus acidophilus*?

It is most effective when taken with meals to improve its survival through the stomach.

What health benefits should I expect?

Users may see improvements in gut health and reductions in cholesterol levels, but outcomes can vary widely.

Are there misconceptions about *Lactobacillus acidophilus*?

Yes, many overestimate its effectiveness for all gastrointestinal issues; it is not a cure-all.

Research Sources

https://www.frontiersin.org/journals/gastroenterology/articles/10.3389/fgstr.2022.983075/full – This study reviews the use of probiotics, including *L. acidophilus*, for managing diarrhea, highlighting limited clinical benefits recognized across existing literature.
https://pubmed.ncbi.nlm.nih.gov/26473340/ – A meta-analysis of eleven randomized controlled trials revealing that probiotics, especially *L. acidophilus*, can significantly reduce total cholesterol and LDL-C, confirming the benefit of these microorganisms on lipid profiles.
https://pubmed.ncbi.nlm.nih.gov/35277042/ – This systematic review evaluates the efficacy of *L. acidophilus* in treating acute gastroenteritis in children, showing some reduction in diarrhea duration but often lacking statistical significance.
https://pubmed.ncbi.nlm.nih.gov/35820261/ – Explores the link between *Lactobacillus* supplementation and glycemic control in overweight populations, supporting its role in metabolic health.
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1168582/full – This article includes recent findings on *L. acidophilus*, discussing its role and efficacy in various health conditions, alongside methodological assessments of current studies.