Lactobacillus Casei Casei
Also known as: *L. casei*, Casei, Lactobacillus casei, *Lactobacillus casei*
Overview
*Lactobacillus casei* is a probiotic bacterium within the *Lactobacillus* genus, commonly found in fermented foods such as yogurt and cheese. This beneficial bacterium supports gut health and has been shown to modulate the immune system. Due to its strain-specific effects, it can alter the gut microbiota composition and contribute to digestive health. Research concerning *L. casei* has shown promise in applications such as the prevention of antibiotic-associated diarrhea (AAD) and enhancing immune response. The current research maturity indicates moderate levels of investigation, with several randomized controlled trials (RCTs) and meta-analyses supporting its benefits, though the quality of evidence varies between studies. Overall, *L. casei* represents a valuable addition to probiotic therapies aimed at improving gastrointestinal health.
Benefits
*Lactobacillus casei* offers several evidence-based benefits. Specifically, the strain *L. casei* DN-114001 significantly reduces the incidence of antibiotic-associated diarrhea (AAD), showing a relative risk reduction (RR) of 0.32 (95% CI 0.16, 0.63) in adults. Another strain, *L. casei* LTL1879, has demonstrated improvements in immune and oxidative markers among healthy volunteers. The modulation of gut microbiota and enhancement of the immune response further underline its potential, especially in adult populations. These benefits typically manifest within days to weeks of regular supplementation. However, evidence strength varies, underscoring the need for strain-specific investigations.
How it works
*Lactobacillus casei* mainly alters gut microbiota composition by colonizing the gut and influencing immune responses through the activation of pattern recognition receptors (PRRs) and modulation of antimicrobial peptides (AMPs). This interaction predominantly affects the gastrointestinal and immune systems, facilitating better gut health and immune function. While specific molecular targets have not been clarified, the overall impact on microbial ecology is significant, supporting host health by maintaining a balanced microbiome.
Side effects
Overall, *Lactobacillus casei* is generally safe for healthy individuals, with mild gastrointestinal symptoms such as bloating and gas being the most common side effects (>5%). No consistent reports of rare side effects (<1%) have been documented, though there is a potential risk for systemic infections amongst immunocompromised individuals. No significant drug interactions have been noted, but contraindications exist for individuals with severe immunodeficiency, who should consult healthcare providers before use. Thus, while generally considered safe, caution is advised for at-risk populations to mitigate any potential adverse reactions.
Dosage
The dosage of *Lactobacillus casei* can vary based on specific strain and health goals, with a minimum effective dose generally considered around 10^8 to 10^9 CFU per day, although optimal ranges are not firmly established. Timing plays a vital role in efficacy; taking it with food is recommended to enhance survival through the stomach. The overall safety ceiling for doses has not been conclusively determined, but typical probiotic dosages are deemed safe. Fermented foods and capsules are common delivery methods for achieving effective dosing.
FAQs
How should I store *Lactobacillus casei* supplements?
Keep *Lactobacillus casei* supplements in a cool, dry place and refrigerate if possible to maintain viability.
Is *Lactobacillus casei* safe for everyone?
While generally safe, consult a healthcare provider if you are immunocompromised before using.
When is the best time to take *Lactobacillus casei*?
It is best taken with food to enhance the survival of probiotics through the digestive tract.
How quickly can I see results from *Lactobacillus casei*?
Benefits like improved gut health may take several days to become noticeable.
Are all *Lactobacillus casei* strains equally effective?
No, effects can vary significantly between strains, so it’s important to choose specific strains with evidence for your needs.
Research Sources
- https://onlinelibrary.wiley.com/doi/10.1177/2050640617736987 – This meta-analysis highlights *L. casei* DN-114001's effectiveness in significantly reducing the incidence of AAD in various populations, contributing high-quality evidence from pooled RCTs.
- https://pubmed.ncbi.nlm.nih.gov/27244133/ – A pilot study showed that *L. casei* LTL1879 improved immune and oxidative markers in healthy volunteers, although its small sample size limited the generalizability of findings.
- https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2018.00124/full – Research on numerous *L. casei* strains demonstrated strain-specific effects on gut microbiota and immune modulation, contributing moderate-quality evidence mainly from animal models.
- https://pubmed.ncbi.nlm.nih.gov/34836153/ – This source explores various mechanisms of *Lactobacillus casei* in relation to gut health, particularly focusing on immune interactions and microbiota alterations.
- https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2018.02107/full – This article discusses the role of different *Lactobacillus* strains, including *L. casei*, in promoting health through modifications of the gut microbiome and immune function.
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