Lactobacillus Crispatus Lbv 88
Also known as: Lactobacillus crispatus LbV 88 (DSM 22566), L. crispatus LbV 88, Lactobacillus crispatus, Lactobacillus crispatus LbV 88
Overview
Lactobacillus crispatus LbV 88 is a strain of lactic acid bacteria that is naturally found in the human vagina and gut. It is a probiotic supplement primarily used to support vaginal health and treat conditions like bacterial vaginosis. This bacterium is known for its ability to adhere to epithelial cells and produce lactic acid, which helps maintain a healthy pH balance in the vagina, inhibiting the growth of harmful bacteria. It is often administered orally, sometimes in combination with other Lactobacillus strains, to improve vaginal dysbiosis. Research on L. crispatus LbV 88 is considered to be at a moderate maturity level, with several studies focusing on its effects on vaginal health. The available evidence is generally of good quality, with systematic reviews and meta-analyses supporting its efficacy in improving vaginal microbiota.
Benefits
Oral administration of Lactobacillus crispatus LbV 88, often in combination with other Lactobacillus strains, has been shown to improve vaginal dysbiosis. A meta-analysis indicated that this combination significantly improved the microbial pattern in vaginal dysbiosis, with an odds ratio of 3.902 (CI 1.681 to 9.059; P=0.001). This suggests a significant improvement in Nugent scores, indicating healthier vaginal microbiota. The benefits are typically observed within weeks of consistent use. While primarily studied for vaginal health, it may also support overall gut health, though this is less well-studied in the context of vaginal health. It is particularly beneficial for women experiencing vaginal dysbiosis or bacterial vaginosis.
How it works
Lactobacillus crispatus LbV 88 works by colonizing the vagina and producing lactic acid. This lactic acid helps maintain a healthy, acidic pH, which inhibits the growth of harmful bacteria. The bacterium interacts with the vaginal microbiome to promote a balanced ecosystem. When taken orally, it can influence both gut and vaginal microbiota, though the exact mechanisms of absorption and transport to the vaginal area are not fully understood. It influences the microbial community structure, promoting a balanced vaginal environment.
Side effects
Lactobacillus crispatus LbV 88 is generally considered safe with minimal side effects. Common side effects, occurring in more than 5% of users, include mild gastrointestinal symptoms such as bloating or gas. Uncommon side effects, affecting 1-5% of users, are not commonly reported. Serious adverse effects are rare and not well-documented. No significant drug interactions have been reported. It is generally safe for most populations, but caution is advised in immunocompromised individuals. Pregnant or breastfeeding women should consult healthcare providers before use to ensure safety.
Dosage
The minimum effective dose is typically around 10^7 CFU/mL when used in combination with other strains. It is often used in combination with other Lactobacillus strains at dosages ranging from 10^7 to 10^9 CFU per serving. While the maximum safe dose is not well-defined, high doses are generally well-tolerated. For best results, it should be taken consistently over several weeks. Capsules or oral supplements are common forms. Oral administration is effective, but specific absorption factors are not well-documented. No specific cofactors are required for its function.
FAQs
How should I take Lactobacillus crispatus LbV 88?
Maintain consistent dosing and consider combining with other probiotic strains for enhanced effects. It is generally safe, but consult a healthcare provider if you have specific health concerns.
When is the best time to take this supplement?
It is best taken orally with food to minimize gastrointestinal upset. Consistent use over several weeks is recommended to achieve noticeable benefits.
What results can I expect?
Expect improvement in vaginal health and a reduction in symptoms of bacterial vaginosis. It is not a cure-all for vaginal infections and should be used under medical guidance if treating a condition.
Is Lactobacillus crispatus LbV 88 safe?
Generally safe for most people, but those with compromised immune systems should exercise caution. Pregnant or breastfeeding women should consult their healthcare provider before use.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/31012733/ – This meta-analysis evaluated the effect of oral administration of a mixture including Lactobacillus crispatus LbV 88 on vaginal dysbiosis. The study found a significant improvement in the microbial pattern, with an odds ratio of 3.902 (CI 1.681 to 9.059; P=0.001), indicating a positive impact on vaginal health.
- https://www.ingentaconnect.com/content/wagac/bm/2019/00000010/00000005/art00001?crawler=true&mimetype=application%2Fpdf – This systematic review assessed the methodological quality of studies involving the same probiotic mixture, confirming its efficacy in improving vaginal health based on Nugent scores. The review supports the use of Lactobacillus crispatus LbV 88 in improving vaginal health outcomes.
- https://www.imrpress.com/journal/CEOG/50/3/10.31083/j.ceog5003050/htm – This randomized controlled trial used a combination of Lactobacillus strains, including L. crispatus LbV 88, and found improvements in vaginal health outcomes over four weeks. The study provides evidence for the effectiveness of this probiotic combination in promoting vaginal health.
- https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.963868/pdf – This study provides insights into the mechanisms by which Lactobacillus crispatus contributes to vaginal health. It highlights the role of lactic acid production and the maintenance of a healthy vaginal pH.
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