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Lactobacillus crispatus LBV88

Also known as: Lactobacillus crispatus, L. crispatus, Lactobacillus crispatus LbV 88, LbV 88, DSM 22566

Overview

Lactobacillus crispatus is a species of lactic acid bacteria naturally found in the human vagina and gut, playing a crucial role in maintaining vaginal health. As a probiotic supplement, particularly the strain LbV 88 (DSM 22566), it is primarily used to support vaginal health and treat conditions like bacterial vaginosis. This bacterium is known for its ability to adhere to epithelial cells and produce lactic acid, which helps maintain a healthy pH balance in the vagina, inhibiting the growth of harmful bacteria. It is available in various forms, including capsules and oral supplements, often used in combination with other Lactobacillus strains to enhance its effects. Research on Lactobacillus crispatus is moderately mature, with good-quality evidence from systematic reviews and meta-analyses supporting its efficacy in improving vaginal microbiota and overall vaginal health.

Benefits

Lactobacillus crispatus, particularly the LbV 88 strain, offers significant benefits for vaginal health. Studies have demonstrated that oral administration of L. crispatus LbV 88, often combined with other Lactobacillus strains, effectively improves vaginal dysbiosis. A meta-analysis indicated a significant improvement in the microbial pattern in vaginal dysbiosis, with an odds ratio of 3.902 (CI 1.681 to 9.059; P=0.001). This probiotic is especially beneficial for women experiencing vaginal dysbiosis or bacterial vaginosis, showing notable improvements in Nugent scores, which indicate healthier vaginal microbiota. Benefits are typically observed within a few weeks of consistent use. While less studied in the context of vaginal health, it may also support overall gut health.

How it works

Lactobacillus crispatus works primarily by colonizing the vagina and producing lactic acid, which helps maintain a healthy pH level, typically between 3.5 and 4.5. This acidic environment inhibits the growth of harmful bacteria, preventing conditions like bacterial vaginosis. The bacterium interacts with the vaginal microbiome to promote a balanced ecosystem. When taken orally, Lactobacillus crispatus can influence both gut and vaginal microbiota, although the exact mechanisms of absorption and transport to the vagina are not fully understood. Its influence on the microbial community structure is a key factor in its effectiveness.

Side effects

Lactobacillus crispatus is generally considered safe with minimal side effects. The most commonly reported side effects are mild gastrointestinal symptoms such as bloating or gas, affecting more than 5% of users. Uncommon side effects, occurring in 1-5% of users, are not commonly reported. Serious adverse effects are rare and not well-documented, affecting less than 1% of users. No significant drug interactions have been reported. While generally safe for most populations, caution is advised for immunocompromised individuals. Pregnant or breastfeeding women should consult healthcare providers before use to ensure safety. It is important to discontinue use and consult a healthcare provider if any unexpected or severe symptoms occur.

Dosage

The minimum effective dose of Lactobacillus crispatus, particularly when used in combination with other strains, is typically around 10^7 CFU/mL. Optimal dosages often range from 10^7 to 10^9 CFU per serving when combined with other Lactobacillus strains. While the maximum safe dose is not well-defined, high doses are generally well-tolerated. For best results, it should be taken consistently over several weeks. Capsules or oral supplements are the common forms. Oral administration is effective, and no specific cofactors are required. It is advisable to follow the dosage instructions on the product label or as directed by a healthcare provider.

FAQs

How should I take Lactobacillus crispatus for best results?

For optimal results, maintain consistent dosing and consider combining it with other probiotic strains. Take it orally with food to minimize gastrointestinal upset.

Is Lactobacillus crispatus safe to use?

It is generally safe, but consult a healthcare provider if you have specific health concerns or are pregnant/breastfeeding. Discontinue use if you experience any adverse effects.

What are the expected benefits of taking Lactobacillus crispatus?

You can expect improvements in vaginal health and a reduction in symptoms of bacterial vaginosis with consistent use. It helps maintain a healthy vaginal pH and microbial balance.

Can Lactobacillus crispatus cure vaginal infections?

It is not a cure-all for vaginal infections and should be used under medical guidance if treating a condition. It's best used as a supportive measure alongside conventional treatments.

Are there any side effects?

Some people may experience mild gastrointestinal symptoms like bloating or gas. Serious side effects are rare. Consult a healthcare provider if you have concerns.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/31012733/ – This meta-analysis evaluated the effect of oral administration of a mixture including Lactobacillus crispatus LbV 88 on vaginal dysbiosis. The study found significant improvement in the microbial pattern, with an odds ratio of 3.902 (CI 1.681 to 9.059; P=0.001), indicating a positive impact on vaginal health.
https://www.ingentaconnect.com/content/wagac/bm/2019/00000010/00000005/art00001?crawler=true&mimetype=application%2Fpdf – This systematic review assessed the methodological quality of studies involving a probiotic mixture containing Lactobacillus crispatus LbV 88, confirming its efficacy in improving vaginal health based on Nugent scores. The review supports the use of this probiotic mixture for enhancing vaginal microbiota and reducing dysbiosis.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12059960/ – This article discusses the role of Lactobacillus species in maintaining a healthy vaginal ecosystem. It highlights how Lactobacillus crispatus contributes to vaginal health by producing lactic acid, which helps maintain an acidic pH and inhibits the growth of pathogenic bacteria, thus preventing infections.
https://www.imrpress.com/journal/CEOG/50/3/10.31083/j.ceog5003050/htm – This study investigates the impact of Lactobacillus crispatus on vaginal health and its potential to prevent or treat bacterial vaginosis. The research emphasizes the importance of L. crispatus in maintaining a balanced vaginal microbiota and its role in preventing the overgrowth of harmful bacteria.
https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.963868/pdf – This research explores the cellular and infection microbiology aspects of Lactobacillus crispatus, focusing on its mechanisms of action in preventing infections. The study provides insights into how L. crispatus interacts with the vaginal epithelium and modulates the immune response to protect against pathogens.