Lactobacillus Crispatus Lcr01 Dsm 24619
Also known as: *Lactobacillus crispatus*, LCR01, DSM 24619, Lactic acid bacteria, *Lactobacillus crispatus* LCR01 DSM 24619
Overview
*Lactobacillus crispatus* LCR01 DSM 24619 is a specific strain of lactic acid bacteria found predominantly in the human vagina. It plays a crucial role in maintaining vaginal health by promoting a balanced microbiome and inhibiting the growth of pathogenic microorganisms. This strain has been studied for its effects on preventing genitourinary infections, preserving vaginal health, and possibly reducing the risk of preterm birth by maintaining a healthy vaginal environment. Current research indicates a moderate level of evidence for its benefits, supported by several randomized controlled trials (RCTs) and systematic reviews. The supplements are commonly available in both oral and vaginal formulations, enhancing direct benefits to the vaginal microbiota.
Benefits
Evidence suggests that *Lactobacillus crispatus* can significantly reduce symptoms of bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC), thereby improving overall vaginal health. Clinical studies have demonstrated notable improvements in Nugent scores (a standard measure of BV severity). This strain is particularly beneficial for women suffering from these conditions or at risk of preterm birth. The clinical significance of the findings has been supported by high-quality RCTs, showing immediate improvements within a few months of continuous supplementation. Additionally, *L. crispatus* has been linked to overall reproductive health by modulating the vaginal microbiota.
How it works
*Lactobacillus crispatus* modulates the vaginal microbiota by outcompeting pathogenic bacteria and maintaining a favorable balance of beneficial lactobacilli. It aids in local immune responses which enhance the body's defense mechanisms against infections. When administered vaginally, it directly colonizes the area, while oral administration could impact the gut-vaginal axis indirectly, influencing vaginal flora through systemic routes.
Side effects
Generally, *Lactobacillus crispatus* is considered safe with few reported adverse effects. Mild gastrointestinal symptoms have been noted in over 5% of those taking it orally, but other side effects are uncommon. No significant drug interactions or contraindications exist, making it a safe option for most populations, including pregnant women. However, as with any supplement, it is advisable to consult a healthcare provider before starting, especially for individuals with existing health concerns or those on medication.
Dosage
The dosing guidelines for *Lactobacillus crispatus* are not well defined, as they often vary by product and formulation. It is recommended as part of a multi-strain probiotic, with dosages usually guided by product labeling or healthcare providers. For optimal results, continuous use is advised, and effective delivery via vaginal administration shows better colonization than oral forms. There are no established maximum safe doses, but users should follow specific product recommendations for safety and efficacy.
FAQs
Is *Lactobacillus crispatus* safe to use?
Yes, it is generally considered safe, but it is advisable to monitor for any mild gastrointestinal symptoms.
What are the expected results from using this supplement?
Users can expect improved vaginal health and a lower risk of infections, particularly with ongoing use.
How should I take *Lactobacillus crispatus*?
Follow product guidelines or consult a healthcare provider; it can be taken orally or vaginally.
Can it help with recurrent vaginal infections?
Yes, studies indicate it can assist in reducing recurrence of conditions like BV and VVC.
Is there a maximum dose for this probiotic?
There is no established maximum dose, but stick to product directions and consult a provider.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/33579685/ – This randomized, double-blind, placebo-controlled trial involved 182 participants and reported significant reductions in symptoms of BV and VVC with the oral and vaginal application of *L. crispatus* capsules over three months.
- https://pure.johnshopkins.edu/en/publications/the-vaginal-microbiome-and-the-risk-of-preterm-birth-a-systematic – A systematic review showing that the absence of lactobacilli increases preterm birth risk, whereas the presence of *L. crispatus* reduces this risk, which emphasizes its importance in reproductive health.
- https://pubmed.ncbi.nlm.nih.gov/36856121/ – This metagenomic analysis of 94 samples highlighted *L. crispatus* prevalence in healthy vaginal microbiomes and its negative correlation with pathogenic bacteria, underscoring its protective role in vaginal health.
- https://pubmed.ncbi.nlm.nih.gov/35562576/ – This study details the implications of *L. crispatus* in managing vaginal infections and provides evidence of its efficacy in improving vaginal health parameters.
- https://activatedprobiotics.com.au/wp-content/uploads/2022/01/AP_Product-Comparison_Guide.pdf – This document outlines various probiotic products, with a note on the inclusion of *L. crispatus* as a beneficial strain for women's health, demonstrating the increasing recognition of probiotics in gynecology.
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