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Lactobacillus fermentum

Also known as: Limosilactobacillus fermentum, Lactobacillus fermentum, L. fermentum

Overview

*Limosilactobacillus fermentum*, commonly known as *L. fermentum*, is a probiotic bacteria belonging to the lactic acid bacteria group. It is naturally found in fermented foods and resides within the human gut, contributing to the balance of the gut microbiota. As a dietary supplement, *L. fermentum* is primarily used to support gastrointestinal health and potentially prevent infections, particularly in infants. This probiotic is characterized by its ability to produce lactic acid, which aids in maintaining a healthy gut environment. While research on *L. fermentum* is still evolving, current studies suggest promising preventive effects against gastrointestinal infections. It is available in various forms, including capsules and powders, and is often included in probiotic supplements to promote digestive wellness. The quality of available evidence is moderate, with ongoing research aimed at further elucidating its benefits and mechanisms of action.

Benefits

The primary benefit of *L. fermentum* is its potential to reduce the incidence of gastrointestinal infections, particularly in infants. A systematic review and meta-analysis indicated that early administration of *L. fermentum* CECT5716 significantly lowered the rate of these infections, with an incidence rate ratio (IRR) of 0.52 (95% CI: 0.36–0.74, *p* = 0.0004). This suggests a clinically significant protective effect. While there is limited evidence on other benefits, such as immune system support or effects on atopic dermatitis, the reduction in gastrointestinal infections is the most well-documented and clinically relevant benefit. Further research is needed to explore additional potential health benefits and the time course of these effects.

How it works

*L. fermentum* exerts its beneficial effects primarily by modulating the gut microbiota, enhancing the gut barrier function, and potentially influencing immune responses. As a probiotic, it contributes to a balanced gut environment by producing lactic acid and competing with harmful bacteria. While the exact molecular targets are not well-defined, *L. fermentum* interacts directly with the gastrointestinal system, promoting a healthy gut flora. Since probiotics like *L. fermentum* are not absorbed into the bloodstream, their effects are localized within the gut, where they support digestive health and overall well-being.

Side effects

*L. fermentum* is generally considered safe for use in dietary supplements. The most common side effects are mild gastrointestinal symptoms such as bloating or gas, which occur in more than 5% of users. Uncommon side effects are not well-documented. Rare but serious adverse effects may include infections in severely immunocompromised individuals. There are no significant drug interactions reported, but caution is advised in patients with compromised immune systems. It is generally not recommended for severely immunocompromised individuals. Overall, *L. fermentum* has a favorable safety profile, but individuals with specific health concerns should consult with a healthcare provider before use.

Dosage

The minimum effective dose of *L. fermentum* is not well-established. Optimal dosage ranges typically fall between 1-10 billion CFU per serving, as found in many probiotic supplements. The maximum safe dose has not been definitively established. For best results, it is recommended to take *L. fermentum* with food to enhance its survival through the stomach. It is commonly available in capsule or powder form. The efficacy of *L. fermentum* depends on its ability to survive through the stomach and small intestine, allowing it to exert its beneficial effects in the gut. There are no documented required cofactors for its activity.

FAQs

How should I store *L. fermentum* supplements?

Store *L. fermentum* supplements as directed on the product label, typically in a cool, dry place, to maintain the viability of the probiotic bacteria.

Is *L. fermentum* safe for everyone?

*L. fermentum* is generally safe, but individuals who are severely immunocompromised should consult a healthcare provider before use.

When is the best time to take *L. fermentum*?

It is generally recommended to take *L. fermentum* with food to enhance its survival through the stomach and improve its effectiveness.

What results can I expect from taking *L. fermentum*?

Taking *L. fermentum* may help reduce the risk of gastrointestinal infections, particularly in infants, and support overall gut health.

Is *L. fermentum* a cure for all gastrointestinal problems?

No, *L. fermentum* is not a cure for all gastrointestinal issues. It is a probiotic that can support gut health but should not be considered a standalone treatment for serious conditions.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC8305821/ – This systematic review and meta-analysis of 435 infants found that early administration of *L. fermentum* CECT5716 significantly reduced the incidence rate of gastrointestinal infections. The study reported a clinically significant protective effect, with an incidence rate ratio (IRR) of 0.52 (95% CI: 0.36–0.74, *p* = 0.0004), indicating a substantial reduction in infection rates.
https://pubmed.ncbi.nlm.nih.gov/34208893/ – This study highlights the positive effect of *L. fermentum* on gastrointestinal infections in infants. The research suggests that *L. fermentum* can be a beneficial probiotic for preventing gastrointestinal issues in this population, supporting its use as a preventive measure.
https://hcp.hipp.com/studies/research-on-hipp-milk-formulae/positive-effect-of-l-fermentum-on-gastrointestinal-infections-in-infants/ – This research on HiPP milk formulae indicates a positive effect of *L. fermentum* on gastrointestinal infections in infants. The findings suggest that incorporating *L. fermentum* into infant formula can help reduce the risk of gastrointestinal issues, promoting better digestive health.
https://onlinelibrary.wiley.com/doi/abs/10.1111/pai.13305 – This systematic review and network meta-analysis focused on pediatric atopic dermatitis and did not highlight *L. fermentum* as a top strain for this condition. While the methodology was high-quality, the study's focus on atopic dermatitis rather than gastrointestinal health makes it less directly relevant to the primary benefits of *L. fermentum*.
https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0178868 – This study provides insights into the genetic and functional characteristics of *L. fermentum*, contributing to a better understanding of its probiotic properties. The research helps elucidate the mechanisms by which *L. fermentum* interacts with the gut microbiota and supports overall digestive health.