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Lactobacillus Gasseri Lbv 150n

Also known as: Lactobacillus gasseri LbV 150N, L. gasseri, Lactobacillus gasseri Lbv 150n, Lactobacillus gasseri

Overview

Lactobacillus gasseri is a species of lactic acid bacteria naturally found in the human gut and vagina. As a probiotic, it's primarily used to support gut health and maintain a balanced vaginal microbiota. This bacterium produces lactic acid and hydrogen peroxide, contributing to a healthy vaginal pH balance. Research on L. gasseri is moderately mature, with studies focusing on its impact on vaginal health and gut microbiota composition. Available evidence generally supports its use in improving vaginal microbiota, often as part of a probiotic mixture. It is available in various forms, including capsules, tablets, and probiotic drinks.

Benefits

Oral intake of *L. gasseri*, often as part of a probiotic mixture, has demonstrated significant improvements in vaginal dysbiosis, as indicated by improvements in Nugent scores. This suggests a potential role in reducing the risk of bacterial vaginosis by fostering a healthy vaginal microbiota. These benefits are particularly relevant for women experiencing vaginal dysbiosis or bacterial vaginosis. Studies have shown clinically significant improvements in vaginal health outcomes within weeks of consistent use as part of a probiotic regimen.

How it works

*Lactobacillus gasseri* produces lactic acid and hydrogen peroxide, which are key to maintaining a healthy vaginal pH and inhibiting the growth of pathogenic bacteria. It interacts with both the vaginal and gut microbiota, promoting a balanced microbial ecosystem. While specific molecular targets are not well-defined, its metabolic products influence microbial growth and pH balance. As a probiotic, it colonizes the gut or vagina, exerting its effects locally rather than being absorbed systemically.

Side effects

*Lactobacillus gasseri* is generally considered safe as a probiotic supplement. Common side effects, affecting more than 5% of users, include mild gastrointestinal symptoms such as bloating or gas. Uncommon side effects, occurring in 1-5% of users, are not commonly reported. Rare side effects, affecting less than 1% of users, include the potential for systemic infections in severely immunocompromised individuals. No significant drug interactions have been reported. It is generally not recommended for severely immunocompromised individuals. Pregnant or breastfeeding women should consult healthcare providers before use.

Dosage

While a minimum effective dose of *Lactobacillus gasseri* alone is not well-defined, it is often used in combination with other probiotics like *L. crispatus* and *L. rhamnosus*. An optimal dosage range for *L. gasseri* specifically has not been established. High doses are generally well-tolerated. It is best taken with food to enhance its survival through the stomach. *L. gasseri* is available in capsules, tablets, or as part of probiotic drinks. As a probiotic, it colonizes the gut or vagina rather than being absorbed.

FAQs

How should *L. gasseri* be stored to maintain its viability?

It should be stored according to the manufacturer's instructions, typically in a cool, dry place, to ensure the probiotic bacteria remain viable and effective.

Is *L. gasseri* safe for everyone?

Generally safe, but individuals who are severely immunocompromised should consult a healthcare provider before use due to a small risk of systemic infection.

When is the best time to take *L. gasseri*?

It is generally recommended to take it with meals to improve the survival of the bacteria as it passes through the acidic environment of the stomach.

What results can I expect from taking *L. gasseri*?

Users may experience improvements in vaginal health or gut microbiota balance, but individual results can vary. It is not a guaranteed cure for all vaginal infections.

Is *L. gasseri* a cure for vaginal infections?

No, it is not a cure for all vaginal infections. It may help improve vaginal health and reduce dysbiosis, but it may not work for everyone and should be used as part of a comprehensive treatment plan.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/31012733/ – This study investigated the impact of probiotics on vaginal microbiota. The meta-analysis showed that oral administration of a probiotic mixture including *L. gasseri* significantly improved vaginal microbiota, as measured by Nugent scores, suggesting a beneficial role in addressing vaginal dysbiosis. The research highlights the potential of probiotics in promoting a healthier vaginal environment.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9366906/ – This review discusses the role of probiotics in managing bacterial vaginosis. The systematic review and meta-analysis indicated that probiotics, including strains like *L. gasseri*, may help in treating bacterial vaginosis by promoting a healthy vaginal environment. The findings support the use of probiotics as an adjunct therapy for improving vaginal health.
https://www.ingentaconnect.com/content/wagac/bm/2019/00000010/00000005/art00001?crawler=true&mimetype=application%2Fpdf – This research highlights the role of *Lactobacillus* species, including *L. gasseri*, in maintaining vaginal health. The study emphasizes the production of compounds by these bacteria that inhibit pathogens, contributing to a balanced vaginal ecosystem. The findings underscore the importance of *Lactobacillus* species in promoting and maintaining vaginal health.
https://www.imrpress.com/journal/CEOG/50/3/10.31083/j.ceog5003050/htm – This article discusses the clinical efficacy of probiotics in obstetrics and gynecology. The review suggests that probiotics, including *L. gasseri*, can be beneficial in improving vaginal health and reducing the risk of infections. The research supports the use of probiotics as a complementary approach to traditional treatments.
https://article.imrpress.com/journal/CEOG/50/3/10.31083/j.ceog5003050/a57bd7e495f1a47c53c5423f05940a63.pdf – This study provides a detailed analysis of the mechanisms by which probiotics, including *L. gasseri*, exert their beneficial effects on vaginal health. The research highlights the production of lactic acid and other antimicrobial compounds that inhibit the growth of pathogens. The findings contribute to a better understanding of the role of probiotics in maintaining a healthy vaginal microbiota.