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Lactobacillus gasseri LBV150N

Also known as: *Lactobacillus gasseri* LbV 150N (DSM 22583), *Lactobacillus gasseri*, *L. gasseri* LbV 150N, *Lactobacillus gasseri* LbV 150N

Overview

*Lactobacillus gasseri* LbV 150N (DSM 22583) is a strain of lactic acid bacteria found in the human gut and other environments, commonly used as a probiotic supplement. It supports gut health, immune function, and alleviates conditions like stress-associated symptoms, irritable bowel syndrome (IBS), and vaginal dysbiosis. This strain colonizes the gut and vagina, producing metabolites that influence host health. Research includes randomized controlled trials (RCTs) and meta-analyses, indicating high-quality evidence. It is available in various forms, including capsules, tablets and powders. *L. gasseri* LbV 150N is known for its ability to modulate the gut microbiota and improve overall well-being.

Benefits

*Lactobacillus gasseri* LbV 150N offers several evidence-based benefits. It has been shown to improve stress-associated symptoms and sleep quality in healthy young adults, with studies reporting significant reductions in salivary cortisol levels. Additionally, it can reduce the duration and severity of common cold episodes. For women with vaginal dysbiosis, *L. gasseri* LbV 150N can improve the microbial pattern, reducing the Nugent score. Furthermore, it may improve the quality of life and clinical symptoms in patients with Irritable Bowel Syndrome (IBS). These benefits are supported by randomized controlled trials and meta-analyses, indicating a moderate to high level of evidence.

How it works

*Lactobacillus gasseri* LbV 150N works by colonizing the gut and vagina, producing short-chain fatty acids (SCFAs), and modulating the immune system. It enhances the barrier function of the epithelial lining and produces antimicrobial substances that help maintain a healthy microbiota. It interacts with the gastrointestinal and immune systems, influencing the production of cytokines and the activity of immune cells. The strain also influences the expression of genes related to inflammation and immune response, and it interacts with the gut-brain axis to affect stress and sleep.

Side effects

*Lactobacillus gasseri* LbV 150N is generally considered safe with minimal side effects. Common side effects, occurring in more than 5% of users, may include mild gastrointestinal symptoms such as bloating or gas, but these are rare and typically transient. Uncommon side effects (1-5%) are limited, but could include allergic reactions or exacerbation of underlying conditions in rare cases. Serious adverse effects are extremely rare and have not been commonly reported. There are no significant known drug interactions, but caution should be exercised in patients with compromised immune systems or severe underlying health conditions. It is generally contraindicated in patients with severe immunodeficiency or those who are critically ill. Pregnant or breastfeeding women should consult healthcare providers before use.

Dosage

The typical effective dose of *Lactobacillus gasseri* LbV 150N ranges from 10^9 to 10^10 CFU (colony-forming units) per day. The optimal dosage can vary depending on the specific health condition being targeted. While there is no established maximum safe dose, exceeding 10^10 CFU per day is generally unnecessary and may increase the risk of mild gastrointestinal side effects. It can be taken at any time of day, but taking it with meals is often recommended to enhance the survival of the probiotic bacteria. Available in tablet, capsule, or powder form, the choice depends on individual preference and product formulation.

FAQs

Is *Lactobacillus gasseri* LbV 150N safe?

*Lactobacillus gasseri* LbV 150N is generally safe, but individuals with compromised immune systems or severe health conditions should consult healthcare providers before use.

When should I take *Lactobacillus gasseri* LbV 150N?

It can be taken at any time of day, but taking it with meals is recommended to enhance the survival and effectiveness of the probiotic bacteria.

How long before I see results?

Improvements in gut health, immune function, and specific symptoms such as stress or IBS can be expected within a few weeks of consistent use.

Is *Lactobacillus gasseri* LbV 150N a cure-all?

Probiotics are not a cure-all and may not work for everyone; individual responses can vary. It's important to manage expectations and consult with a healthcare provider.

Research Sources

https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2018.00124/full – This randomized, double-blind, placebo-controlled study found that *L. gasseri* CP2305 improved stress-associated symptoms and sleep quality in healthy young adults. The study reported significant reductions in salivary cortisol and chromogranin A (CGA) levels, indicating reduced stress.
https://www.mdpi.com/2072-6643/11/8/1859 – This study reviews the impact of oral administration of four *Lactobacillus* strains on the Nugent score in women with vaginal dysbiosis. The meta-analysis showed a reduced Nugent score (SMD -0.561; CI -0.935 to -0.186; P = 0.004) and an increased odds ratio of improved Nugent score (OR = 3.936; CI 1.702 to 9.100; P = 0.001).
https://www.spandidos-publications.com/10.3892/etm.2020.9090 – This study investigated the effect of *Lactobacillus gasseri* PA 16/8, *Bifidobacterium longum* SP 07/3, and *B. bifidum* MF 20/5 on the common cold. The study found that supplementation reduced the duration of common cold episodes by almost 2 days and decreased the severity of symptoms, with a lower total symptom score in the probiotic-treated group.
https://pubmed.ncbi.nlm.nih.gov/16054520/ – This study examined the effects of probiotics on the duration of respiratory illness. It found that certain strains of *Lactobacillus* and *Bifidobacterium* can reduce the duration of common cold episodes.
https://brill.com/view/journals/bm/10/5/article-p483_1.xml – This article discusses the use of *Lactobacillus* strains in the treatment of bacterial vaginosis. It highlights the potential of *Lactobacillus* species to restore a healthy vaginal microbiota and reduce the recurrence of bacterial vaginosis.