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Lactobacillus gasseri LGO50

Also known as: Lactobacillus gasseri LGO50, Lactobacillus gasseri (species), strain LGO50, Lactobacillus gasseri

Overview

Lactobacillus gasseri is a species of lactic acid bacteria naturally found in the human gastrointestinal tract and other mucosal sites. The LGO50 strain is a specific isolate used in probiotic formulations. Probiotics like L. gasseri LGO50 are primarily used to modulate gut microbiota, support digestive health, and potentially influence systemic conditions such as immune function, metabolic health, and stress-related symptoms. Key characteristics include its ability to survive gastrointestinal transit, adhere to intestinal mucosa, and produce metabolites beneficial to the host. Research on L. gasseri as a species is mature with numerous clinical trials, but data specifically on the LGO50 strain are limited and less well characterized in high-quality randomized controlled trials (RCTs) or meta-analyses. The quality of evidence for L. gasseri probiotics generally is moderate, with some systematic reviews supporting benefits in specific contexts, but strain-specific data for LGO50 are scarce.

Benefits

Systematic reviews and meta-analyses on *Lactobacillus gasseri* strains (not specifically LGO50) indicate potential benefits in improving sleep quality in adults with mild to moderate stress. A 2023 meta-analysis involving *L. gasseri* CP2305 strain, a closely related but not identical strain, found statistically significant improvements in sleep quality metrics. Other *Lactobacillus* strains have demonstrated benefits in allergic conditions and lipid metabolism, but these findings are not specific to LGO50. No high-quality RCTs or meta-analyses specifically evaluating *L. gasseri* LGO50 were identified in the available literature, limiting conclusions about this strain's unique benefits. The time course for benefits in related strains typically ranges from weeks to months of daily consumption. Therefore, while LGO50 may share some benefits with other *L. gasseri* strains, direct evidence for its specific efficacy is currently lacking.

How it works

*L. gasseri* strains exert their effects primarily through modulation of the gut microbiome, competitive exclusion of pathogens, and production of beneficial metabolites like lactic acid. They also interact with the host immune system, influencing cytokine production and gut barrier function. These mechanisms may contribute to their potential influence on the gut-brain axis, which could explain effects on sleep and stress-related symptoms. The bioavailability of *L. gasseri* LGO50 is dependent on its ability to survive the acidic conditions of the stomach and bile salts in the small intestine, a characteristic for which probiotic strains are specifically selected.

Side effects

Probiotics, including *L. gasseri* strains, are generally regarded as safe for healthy adults. Clinical trials have not reported serious adverse events. Common side effects are typically mild and transient, primarily involving gastrointestinal symptoms such as bloating or gas, which occur in less than 5% of users. No significant drug interactions or contraindications have been specifically documented for *L. gasseri* strains, including LGO50. However, caution is advised for immunocompromised individuals, although no specific safety concerns have been reported for LGO50 in this population. As with any supplement, individuals with underlying health conditions should consult a healthcare professional before use.

Dosage

Due to limited strain-specific data for *L. gasseri* LGO50, dosing recommendations are extrapolated from general probiotic guidelines. A typical daily dosage ranges from 1 billion to 10 billion Colony Forming Units (CFU). Optimal dosing and timing, such as taking with meals, can vary depending on the specific formulation and desired health outcomes. Daily administration for at least 4 weeks is generally recommended to observe potential benefits. There is no established maximum safe dose specifically for LGO50, but probiotic doses up to 10 billion CFU per day are commonly and safely used in clinical trials for other strains.

FAQs

Is LGO50 safe?

Yes, consistent with other *L. gasseri* strains, LGO50 is considered safe for general use in healthy adults, with mild and transient side effects being rare.

How long before effects appear?

Benefits from *L. gasseri* LGO50, if any, may be observed after several weeks of consistent daily intake, similar to other probiotic strains.

Does it improve sleep?

Related *L. gasseri* strains, such as CP2305, have shown promise for improving sleep quality. LGO50 may have similar potential, but direct evidence for this specific strain is currently lacking.

Is it effective for allergies or lipid control?

Evidence for benefits in allergies or lipid control exists for other *Lactobacillus* strains, but not specifically for *L. gasseri* LGO50. More research is needed for this particular strain.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/37413809/ – This systematic review and meta-analysis by Chu et al. (2023) investigated the effect of daily *Lactobacillus gasseri* CP2305 intake on sleep quality in adults with mild to moderate stress. The study, which included multiple RCTs, found statistically significant improvements in sleep quality metrics, suggesting a potential benefit of this related strain for stress-related sleep issues. However, it did not specifically evaluate LGO50.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4725706/ – Zajac et al. (2015) conducted a systematic review and meta-analysis on the effects of probiotics in patients with allergic rhinitis. The findings indicated that probiotics generally improved the quality of life for these patients, although no significant changes in IgE levels were observed. The study highlighted heterogeneity and strain variability among the included studies, and it did not focus on *L. gasseri* LGO50 specifically.
https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0178868 – Wu et al. (2017) performed a meta-analysis of 13 RCTs to assess the impact of probiotics on lipid profiles in adults. The analysis concluded that probiotics reduced total and LDL cholesterol levels, but had no significant effect on triglycerides. This study included various *Lactobacillus* strains, but its findings are not specific to *L. gasseri* LGO50, indicating a broader genus effect rather than a strain-specific one.