Get Your Personalized Supplement StackSupplement Stack Quiz

Lactobacillus gasseri LGS06

Also known as: Lactobacillus gasseri LGS06, L. gasseri LGS06, Lactobacillus gasseri strain LGS06, L. gasseri DSM 32405

Overview

Lactobacillus gasseri LGS06 (DSM 32405) is a specific strain of the lactic acid bacteria species Lactobacillus gasseri, naturally found in the human gastrointestinal and vaginal microbiota. As a probiotic, it's studied for its potential health benefits, particularly in maintaining vaginal health by antagonizing pathogens like Candida albicans and Neisseria gonorrhea. Research also explores its effects on weight management and metabolic health. While research on L. gasseri strains is moderately mature, with several randomized controlled trials and meta-analyses, strain-specific data for LGS06 is more limited. Evidence often stems from studies on the broader L. gasseri species or closely related strains. LGS06 is available in oral capsules and vaginal suppositories.

Benefits

Lactobacillus gasseri LGS06 has several potential benefits. It may aid in weight management and fat reduction, supported by studies on related L. gasseri strains showing beneficial effects on body fat composition. LGS06 contributes to vaginal health by antagonizing common vaginal pathogens, potentially reducing risks associated with infections. Research on a different strain, L. gasseri CP2305, suggests potential improvements in sleep quality in adults experiencing mild to moderate stress, indicating possible strain-specific benefits within the species. Meta-analyses of Lactobacillus strains also suggest potential cardiovascular benefits through reductions in total and LDL cholesterol.

How it works

Lactobacillus gasseri LGS06 exerts its effects through several mechanisms. It contributes to a balanced microbiota by producing lactic acid, lowering pH, and inhibiting pathogen growth in the vaginal and gut environments. LGS06 exhibits antimicrobial activity against pathogens like Candida albicans and Neisseria gonorrhea, likely through competitive exclusion and antimicrobial substance production. It may also influence lipid metabolism and fat storage by modulating gut microbiota and host metabolic pathways, though the exact molecular targets for LGS06 require further elucidation. As a probiotic, LGS06 survives gastric transit to colonize target sites transiently.

Side effects

Lactobacillus gasseri strains, including LGS06, are generally considered safe with a history of use in probiotics. Side effects are rare and typically mild, mainly involving transient gastrointestinal symptoms like bloating or gas. No significant drug interactions have been reported. Caution is advised for immunocompromised individuals due to a theoretical risk of infection, although no specific adverse events have been reported for LGS06. It's important to note that while generally safe, individual reactions can vary, and any persistent or severe symptoms should be discussed with a healthcare professional.

Dosage

Typical dosages of L. gasseri strains in clinical studies range from 10^8 to 10^10 CFU per day; specific dosing for LGS06 varies by formulation and indication. It can be administered through oral capsules or vaginal suppositories, depending on the target condition. While usually taken daily, the timing relative to meals may affect survival but is not well-defined. It is important to follow the specific dosage instructions provided on the product label or as directed by a healthcare professional. There is no established upper limit, but exceeding recommended dosages is not advised.

FAQs

Is LGS06 effective for weight loss?

Evidence from related L. gasseri strains suggests potential benefits in fat reduction, but direct evidence for LGS06 is limited and requires further RCTs. It may support weight management as part of a broader healthy lifestyle.

Can LGS06 improve vaginal health?

Yes, LGS06 is naturally part of healthy vaginal flora and antagonizes pathogens, supporting vaginal microbiota balance. It can help maintain a healthy vaginal environment and reduce the risk of infections.

Is it safe for long-term use?

Generally yes, LGS06 is considered safe for long-term use with minimal side effects reported. However, individuals with compromised immune systems should exercise caution and consult with a healthcare provider.

How should I take LGS06?

Follow the product label instructions or your healthcare provider's advice. It's typically taken orally or as a vaginal suppository, depending on the intended benefit. Consistency is key for optimal results.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/37413809/ – This meta-analysis of RCTs showed that daily consumption of L. gasseri CP2305 significantly improved sleep quality in adults with mild to moderate stress. The study highlights strain-specific probiotic effects within L. gasseri species, demonstrating statistically significant results (p < 0.05) in improving sleep quality.
https://microbiomepost.com/probiotic-strains/lactobacillus-gasseri-lgs06-dsm-32405/ – This review summarizes evidence that LGS06 is associated with vaginal health benefits, antagonism of vaginal pathogens, and potential weight management effects. It references peer-reviewed studies demonstrating these effects, though direct RCT data on LGS06 is less abundant, highlighting the need for further research.
https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0178868 – This systematic review and meta-analysis of 13 RCTs found that Lactobacillus strains significantly reduced total cholesterol and LDL cholesterol levels, supporting cardiovascular health benefits of Lactobacillus probiotics broadly. While specific data on LGS06 was not isolated, the findings support potential metabolic benefits associated with Lactobacillus supplementation.