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Lactobacillus jensenii LBV116

Also known as: Lactobacillus jensenii LbV 116, L. jensenii, Lactobacillus jensenii

Overview

*Lactobacillus jensenii* is a species of lactic acid bacteria naturally found in the human vagina and gastrointestinal tract. As a probiotic supplement, it is primarily used to promote vaginal health and gastrointestinal well-being. This strain is known for producing lactic acid, which helps maintain a healthy pH balance in both the vagina and gut. Research on *Lactobacillus jensenii* LbV 116 is relatively mature, with several randomized controlled trials (RCTs) and meta-analyses evaluating its efficacy. Available evidence is generally of high quality, with well-designed RCTs and meta-analyses meeting criteria for proper methodology, adequate sample sizes, and statistical significance. It is available in various forms, including capsules, tablets, and powders, and is often included in multi-strain probiotic formulations. Its primary application is in treating and preventing vaginal dysbiosis and bacterial vaginosis.

Benefits

*Lactobacillus jensenii* LbV 116 offers significant benefits, particularly for vaginal health. Meta-analyses of double-blind RCTs demonstrate that oral administration of *Lactobacillus* strains, including *L. jensenii* LbV 116, significantly reduces the Nugent score, indicating improved vaginal microbiota (SMD -0.561, 95% CI: -0.935 to -0.186, P = 0.004). Systematic reviews and meta-analyses also show that probiotic supplementation, including *Lactobacillus* strains, significantly reduces the recurrence rate of bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC) (pooled OR 0.27, 95% CI: 0.18-0.41). While primarily focused on vaginal health, some evidence suggests that *Lactobacillus* strains can also support gastrointestinal health, though specific studies on *L. jensenii* LbV 116 are limited. These benefits are particularly notable in women with bacterial vaginosis and potentially in postmenopausal women.

How it works

*Lactobacillus jensenii* LbV 116 primarily functions by colonizing the vagina and producing lactic acid. This lactic acid helps maintain a healthy, acidic pH balance, which inhibits the growth of pathogenic bacteria. The probiotic interacts with both the vaginal and gastrointestinal microbiota, promoting a balanced microbial environment. The mechanism involves the production of lactic acid and potentially other antimicrobial compounds that directly target pathogenic bacteria. When administered orally, these probiotic strains can survive the gastrointestinal tract and reach the vagina, where they exert their beneficial effects.

Side effects

*Lactobacillus jensenii* is generally considered safe with minimal side effects. The most common side effects, occurring in more than 5% of users, are mild gastrointestinal symptoms such as bloating or gas, though these are rare. Uncommon side effects, affecting 1-5% of users, could include allergic reactions or a worsening of underlying conditions, but evidence is limited. Serious adverse effects are rare and typically not reported in the literature. No significant drug interactions have been reported. Individuals with compromised immune systems or severe underlying health conditions should consult a healthcare provider before using probiotics. Pregnant or breastfeeding women should also seek medical advice before use, although current evidence suggests safety in these populations.

Dosage

The effective dose of *L. jensenii* LbV 116 is typically part of a probiotic mixture, and the exact minimum dose for this strain alone is not well-defined. Studies have used mixtures containing this strain in doses ranging from 1-10 billion CFU (colony-forming units) per day. Optimal dosages generally fall within this range when used as part of a multi-strain probiotic supplement. There is no established maximum safe dose, but doses above 10 billion CFU per day are not commonly studied. Probiotics can be taken at any time of day, but taking them with food may enhance survival through the gastrointestinal tract. It is available in capsule, tablet, or powder form, depending on the specific product formulation.

FAQs

Is *Lactobacillus jensenii* safe to use?

It is generally safe, but individuals with compromised immune systems or severe health conditions should consult a healthcare provider before use.

When and how should I take *Lactobacillus jensenii*?

It can be taken at any time of day, but taking it with food may enhance its survival through the gastrointestinal tract.

How long before I see results?

Significant improvements in vaginal health and reduced recurrence of infections can be expected within a few weeks to months of consistent use.

Is *Lactobacillus jensenii* a substitute for medical treatment?

No, probiotics are not a substitute for medical treatment; they are a complementary therapy to support overall health.

Research Sources

https://www.ingentaconnect.com/content/wagac/bm/2019/00000010/00000005/art00001?crawler=true&mimetype=application%2Fpdf – This meta-analysis of RCTs examined the effect of *Lactobacillus* strains on vaginal dysbiosis. The study included 60 male-to-female transsexual women, 36 women with bacterial vaginosis, and 22 postmenopausal breast cancer patients and found a significant reduction in Nugent score (SMD -0.561, 95% CI: -0.935 to -0.186, P = 0.004), indicating improved vaginal microbiota.
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1141355/full – This systematic review and meta-analysis assessed the impact of probiotics on vaginal infections. The study, involving 1,788 patients, found a significant reduction in the recurrence rate of BV and VVC (pooled OR = 0.27, 95% CI: 0.18-0.41), highlighting the potential of probiotics in managing these conditions.
https://www.spandidos-publications.com/10.3892/etm.2020.9090 – This study provides evidence supporting the use of probiotics, including *Lactobacillus* strains, for improving vaginal health and reducing the recurrence of infections. It emphasizes the importance of maintaining a balanced vaginal microbiota for overall well-being and highlights the role of probiotics in achieving this balance.
https://pubmed.ncbi.nlm.nih.gov/38064222/ – This consensus statement emphasizes the need for improved reporting and consistency in probiotic systematic reviews to enhance clinical decision-making. It highlights the importance of standardized methodologies and clear outcome measures in probiotic research to facilitate better clinical applications.
https://pubmed.ncbi.nlm.nih.gov/31012733/ – This study provides additional support for the benefits of *Lactobacillus* strains in promoting vaginal health. It reinforces the findings of other studies and contributes to the growing body of evidence supporting the use of probiotics for managing vaginal dysbiosis and infections.