Lactobacillus Paracasei Dsm 13434
Also known as: Lactobacillus paracasei, L. paracasei, DSM 13434, Lactobacillus paracasei DSM 13434
Overview
Lactobacillus paracasei DSM 13434 is a specific strain of lactic acid bacteria classified as a probiotic. It is prevalent in various fermented foods and is also part of the healthy gut microbiota. This strain is noted for its capabilities in modulating the gut microbiome and enhancing immune function. Research has demonstrated its potential to reduce pathogenic microorganisms and exhibit anti-inflammatory effects. Prominent studies, including randomized controlled trials, showcase a moderate level of maturity in research evidence, indicating promising applications, yet highlighting a necessity for further meta-analyses and clinical trials to conclusively determine its efficacy.
Benefits
The primary benefits of Lactobacillus paracasei DSM 13434 revolve around its immunomodulatory properties and support for gut health. It has been shown to significantly reduce the frequency of Th1 cells and pro-inflammatory cytokines such as IL-17, especially in autoimmune conditions like multiple sclerosis. Noteworthy improvements in specific cytokine production were recorded in patients undergoing treatment. Additionally, in children with celiac disease autoimmunity, this strain effectively lowered autoantibody levels compared to placebo. Although positive outcomes have emerged, variability in effect sizes among studies is observed, underscoring the need for higher quality research for robust confirmation of its health benefits.
How it works
Lactobacillus paracasei DSM 13434 primarily functions through immune modulation, influencing T cell activation and cytokine release. It is known to decrease the frequency of Th1 cells and suppress pro-inflammatory cytokines such as IFN-γ and IL-17. This modulation positively impacts both the gastrointestinal and immune systems, promoting a balanced gut microbiome and mitigating inflammatory responses, which are crucial in managing diverse autoimmune and inflammatory diseases.
Side effects
Lactobacillus paracasei DSM 13434 is generally regarded as safe, with clinical studies reporting no severe adverse effects. The occurrence of common side effects remains below 5%, and rare or uncommon side effects have not been documented. Caution is advised for individuals with compromised immune systems due to insufficient safety data in these populations. Although no significant drug interactions are noted, it is advisable for users to inform their healthcare providers about concurrent medications. Pregnant or breastfeeding individuals, in addition to those with severe immune deficiencies, should consult with healthcare professionals before initiating supplementation to ensure safety and appropriateness.
Dosage
For effective results, the typical recommended dosage of Lactobacillus paracasei DSM 13434 ranges from 10^9 to 10^10 CFU per day, supported by clinical trial findings. Doses as low as 10^9 CFU/day have been employed in some studies, although specific minimal effective doses are not widely defined. Current literature lacks clear upper safety limits, though doses exceeding 10^10 CFU/day are infrequently reported. For optimal probiotic benefits, the strain should ideally be taken with food to enhance gastrointestinal survival, with consistent daily use recommended to sustain beneficial effects.
FAQs
Is *L. paracasei* DSM 13434 safe for everyone?
*L. paracasei* DSM 13434 is generally safe for most individuals, but those with compromised immune systems should consult a healthcare provider prior to its use.
How should I take *L. paracasei* DSM 13434?
Daily administration is recommended, preferably with food, to improve survival rates through the gastrointestinal tract.
What benefits can I expect from this probiotic?
Users can expect immunomodulatory effects, particularly in reducing inflammatory cytokine production, which can help in managing symptoms of autoimmune diseases.
Can *L. paracasei* DSM 13434 cure autoimmune diseases?
No, while it may help manage symptoms by modulating the immune response, it is not a cure for autoimmune diseases.
Research Sources
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543108/ – This systematic review researched the immunomodulatory effects of various Lactobacillus strains, including Lactobacillus paracasei DSM 13434, and highlighted evidence for its potential benefits in autoimmune diseases, as well as the need for further studies to solidify these claims.
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234444/ – An in-depth examination of immune modulation by probiotics, this article includes findings related to Lactobacillus paracasei DSM 13434 and discusses its role in cytokine modulation and impact on Th1 and inflammatory responses.
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