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Lactobacillus plantarum 299v

Also known as: Lactobacillus plantarum 299v, Lp299v, Lactobacillus plantarum DSM 9843

Overview

Lactobacillus plantarum 299v (Lp299v) is a specific strain of probiotic bacteria commonly found in fermented foods such as sauerkraut and pickles. It is utilized as a dietary supplement primarily for its beneficial effects on gastrointestinal health, particularly in managing symptoms associated with irritable bowel syndrome (IBS) and enhancing iron absorption. This strain is well-regarded for its robust ability to survive the acidic environment of the stomach and effectively adhere to the intestinal epithelial cells, which is crucial for its probiotic action. Research on Lp299v is moderately mature, with several clinical trials and meta-analyses supporting its efficacy in specific health conditions, indicating a good quality of evidence.

Benefits

Lactobacillus plantarum 299v offers several evidence-based benefits, particularly for gastrointestinal health and nutrient absorption. A primary benefit is the significant reduction of abdominal pain in individuals with Irritable Bowel Syndrome (IBS); a 4-week treatment showed a 45.2% reduction in pain, compared to 23.3% in the placebo group, indicating a clinically meaningful improvement. Lp299v also significantly enhances iron absorption, as demonstrated by a meta-analysis showing a pooled standardized mean difference of 0.55 (95% CI 0.22-0.88, p = 0.001), making it beneficial for those at risk of iron deficiency anemia. Secondary benefits include improvements in symptoms of bloating and incomplete evacuation in IBS patients. The benefits in IBS symptoms are typically observed within weeks of initiating treatment. The evidence supporting these claims is generally of good quality, derived from well-designed randomized controlled trials (RCTs) and meta-analyses.

How it works

Lactobacillus plantarum 299v exerts its beneficial effects primarily by modulating the gut microbiota, promoting a healthier balance of microorganisms in the digestive tract. It enhances gut barrier function, which helps prevent the leakage of harmful substances from the gut into the bloodstream. Furthermore, Lp299v improves nutrient absorption, notably iron, by creating a more favorable environment in the intestines. Its mechanism involves interaction with the gastrointestinal system, influencing gut motility and reducing inflammation. The strain may also influence cytokine production and directly impact gut epithelial cell function. Its ability to survive stomach acid and adhere to intestinal cells ensures effective colonization and sustained action within the gut.

Side effects

Lactobacillus plantarum 299v is generally considered safe for consumption. The most commonly reported side effects, occurring in more than 5% of users, are mild gastrointestinal symptoms such as bloating or gas, particularly when first starting supplementation. These symptoms are usually transient and resolve as the body adjusts. Uncommon side effects (1-5%) are not commonly reported. Rare side effects, occurring in less than 1% of individuals, include systemic infections, which are extremely rare but a potential concern in severely immunocompromised individuals. There are no significant drug interactions reported with Lp299v. However, it should be used with caution in severely immunocompromised patients. Pregnant women and individuals with compromised immune systems should consult a healthcare provider before using this supplement to ensure safety and appropriateness.

Dosage

The minimum effective dose for Lactobacillus plantarum 299v is typically 10^9 CFU (colony-forming units) per day. The optimal dosage range generally falls between 10^9 to 10^10 CFU per day. While a maximum safe dose is not definitively established, doses up to 10^10 CFU are widely considered safe for regular consumption. For optimal effectiveness, it is best to take Lp299v with meals, as this timing enhances its survival through the acidic environment of the stomach, allowing more viable bacteria to reach the intestines. It is available in various forms, such as capsules or powder, and the choice depends on personal preference. The key to its efficacy lies in its ability to survive stomach acid and colonize the gut. No specific cofactors are required to enhance its absorption or activity.

FAQs

How should I store Lactobacillus plantarum 299v?

To maintain the viability of the probiotic bacteria, ensure the product is stored according to the manufacturer's instructions, typically in a cool, dry place or refrigerated.

Is Lactobacillus plantarum 299v safe for everyone?

It is generally safe, but individuals who are severely immunocompromised, pregnant, or breastfeeding should consult a healthcare provider before use.

When is the best time to take Lp299v?

It is best taken with meals. This helps protect the bacteria from stomach acid, increasing the number of viable organisms that reach the intestines.

How long does it take to see benefits from Lp299v?

Improvements in IBS symptoms and enhanced iron absorption can typically be observed within a few weeks of consistent daily supplementation.

Can Lp299v cure IBS?

No, Lp299v is not a cure for IBS, but it can significantly help manage and alleviate common symptoms such as abdominal pain, bloating, and incomplete evacuation.

Research Sources

https://www.wjgnet.com/1007-9327/full/v18/i30/4012.htm – This randomized controlled trial investigated the effects of L. plantarum 299v on IBS symptoms. It found that a 4-week treatment significantly reduced abdominal pain by 45.2% in IBS patients compared to a placebo, highlighting its efficacy in symptom management. The study was well-designed, though specific sample size details were not provided in the summary.
https://pubmed.ncbi.nlm.nih.gov/31816981/ – This meta-analysis, following PRISMA guidelines, systematically reviewed studies on Lp299v and iron absorption. It concluded that Lp299v significantly increased iron absorption, with a pooled standardized mean difference of 0.55. The study involved a total of 950 participants, acknowledging some heterogeneity in study designs but providing strong evidence for its benefit in iron uptake.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2709042/ – This systematic review supports the use of probiotics, including L. plantarum 299v, for managing IBS symptoms. It provides a comprehensive overview of available literature, though it notes limitations due to variability in the specific probiotic strains studied across different research. The review underscores the potential of probiotics in gut health.