Lactobacillus Plantarum Dsm 15312
Also known as: Lactobacillus plantarum, Lactobacillus plantarum DSM 15312, Lactobacillus plantarum 15312, LP DSM 15312
Overview
Lactobacillus plantarum is a lactic acid bacterium belonging to the normal microbiota found in fermented foods like sauerkraut, kimchi, and sourdough bread. The DSM 15312 strain is extensively used in probiotic supplements, recognized for its considerable health-promoting properties. It plays a vital role in supporting gut health, modulating immune responses, and may help manage significant conditions such as diabetes and autoimmune diseases. Notably, this strain is adept at surviving gastrointestinal transit, producing lactic acid, and interacting with the immune system. Research on Lactobacillus plantarum DSM 15312 is robust, highlighted by numerous randomized controlled trials and meta-analyses that substantiate its efficacy in various health applications.
Benefits
Lactobacillus plantarum DSM 15312 has several evidence-based benefits. Research indicates that it can reduce fasting plasma glucose levels and hemoglobin A1c in patients with type 2 diabetes. Studies have also shown it enhances immune responses by decreasing pro-inflammatory cytokines and increasing anti-inflammatory cytokines. Furthermore, it may lower the incidence of common colds, with younger populations, particularly children with autoimmune tendencies, experiencing significant immune modulation. The evidence supporting these benefits is backed by a range of studies, displaying moderate statistical significance in improving metabolic health and notable effects on immune function.
How it works
Lactobacillus plantarum DSM 15312 functions via multiple biological mechanisms. It plays a role in regulating immune responses by modulating cytokine production; it diminishes levels of pro-inflammatory cytokines like IFN-γ, TNF-α, and IL-4 while promoting IL-10, an anti-inflammatory cytokine. Furthermore, this strain affects gut-associated lymphoid tissue and various T cell subsets, resulting in broad immune modulation throughout the body. Its ability to endure the gastrointestinal environment is paramount for effective colonization and action within the gut.
Side effects
Lactobacillus plantarum DSM 15312 is considered safe for consumption, with minimal reported side effects. Most studies indicate that fewer than 5% of users experienced any common adverse effects. Reports of uncommon or rare side effects are virtually nonexistent. There are no substantial drug interactions linked to this strain, and while no specific contraindications have emerged, individuals with compromised immune systems should approach its use with caution. Pregnant or breastfeeding women and individuals with significant immune deficiencies are advised to seek medical guidance before taking this probiotic.
Dosage
The recommended dosage for Lactobacillus plantarum DSM 15312 typically falls between 10^9 to 10^10 CFU (colony-forming units) per day, with a minimum effective dose established at 10^9 CFU. Although there is currently no defined upper limit on safe dosages, doses above 10^10 CFU are less frequently studied. For optimal results, consistent daily intake is suggested, and it can be taken at any time of the day. This probiotic is available in various forms, including capsules, tablets, and powders, with storage guidelines necessary to maintain its viability. Enteric-coated formulations are recommended to improve absorption and maximize benefits.
FAQs
Is Lactobacillus plantarum safe?
Yes, it is generally safe for consumption, but those with compromised immune systems should consult healthcare providers.
When should I take it?
It can be taken anytime, but consistency in daily dosing is recommended for best results.
What results can I expect?
Users may experience improved glucose and lipid metabolism, enhanced immune function, and decreased incidence of colds.
Is it a cure for diseases?
No, it offers supportive benefits for gut health and immune function but is not a disease cure.
Research Sources
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6574455/ – This study highlights the efficacy of Lactobacillus plantarum DSM 15312 in reducing hemoglobin A1c levels and enhancing immune responses in participants with type 2 diabetes. The randomized controlled trial design reinforces the strength of these findings.
- https://clinicaltrials.gov/ct2/show/NCT03230216 – This clinical trial evaluates the effects of Lactobacillus plantarum DSM 15312 on immune markers in children with autoimmune tendencies, showing beneficial immunomodulatory effects. The study was carefully designed to assess safety and efficacy across different age groups.
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