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Lactobacillus Plantarum Dsm 6595

Also known as: Lactiplantibacillus plantarum 6595, Lactobacillus plantarum 299, Lactobacillus plantarum 67B, L. plantarum DSM 6595, Lactobacillus plantarum DSM 6595

Overview

Lactobacillus plantarum DSM 6595 is a specific probiotic strain belonging to the lactic acid bacteria group, commonly found in fermented foods and the human gastrointestinal tract. It is primarily utilized as a dietary supplement to support gut health and modulate immune function. This strain is recognized for its ability to survive the harsh conditions of the gastrointestinal tract and adhere to the intestinal mucosa via mannose-dependent binding. This adherence mechanism facilitates its interaction with the host's immune system. While research on this specific strain is ongoing, broader meta-analyses on the *L. plantarum* species indicate its immunomodulatory properties. It is generally considered safe for consumption.

Benefits

Meta-analyses of randomized controlled trials (RCTs) involving various *L. plantarum* strains, including those related to DSM 6595, indicate significant modulation of immune markers. Specifically, these strains have been shown to reduce pro-inflammatory cytokines such as IL-4, TNF-α, and IFN-γ, while increasing the anti-inflammatory cytokine IL-10. This suggests an enhanced immune regulation capacity. Some studies also point to its potential in reducing pathogenic intestinal microorganisms, which could contribute to a balanced gut microbiota and a reduced risk of infection. While statistically significant, the effect sizes on cytokine modulation are modest, and further large-scale RCTs are needed to confirm clinical outcomes like infection rate reduction or symptom improvement. The strain can persist in the intestine for up to 11 days post-intake, suggesting potential for sustained effects during supplementation.

How it works

Lactobacillus plantarum DSM 6595 primarily acts locally within the gastrointestinal tract. Its mechanism involves adhering to intestinal epithelial cells through a mannose-dependent binding process, which allows it to colonize the gut and interact directly with the mucosal immune system. This interaction leads to the modulation of immune responses by regulating the production of cytokines, thereby balancing pro-inflammatory and anti-inflammatory signals. Additionally, the strain produces lactic acid and other beneficial metabolites. These metabolites can inhibit the growth of pathogenic bacteria and contribute to strengthening the gut barrier function, further supporting overall gut health.

Side effects

Lactobacillus plantarum DSM 6595 is generally considered safe for consumption, with no significant adverse effects reported in clinical studies or regulatory assessments. There are no common or serious side effects documented in the available literature for this specific strain. Furthermore, no significant drug interactions or contraindications have been reported. While specific warnings for immunocompromised individuals are not noted for this strain, it is generally advised that individuals with compromised immune systems exercise caution when using any probiotic supplements. Overall, the safety profile of *L. plantarum* DSM 6595 appears to be very favorable.

Dosage

Specific dosing guidelines for *Lactobacillus plantarum* DSM 6595 are not yet standardized. However, typical probiotic doses for *L. plantarum* strains in clinical studies generally range from 10^8 to 10^10 Colony Forming Units (CFU) per day. The optimal dose and duration of supplementation for DSM 6595 require further dedicated research. Given that the strain has been shown to persist in the intestine for up to 11 days post-intake, daily administration during the supplementation period is suggested to maintain its presence. While not conclusively established, taking the supplement with meals may potentially enhance its survival through the digestive tract. There are no known cofactors specifically required to enhance its efficacy.

FAQs

Is DSM 6595 effective for immune support?

Evidence from meta-analyses of *L. plantarum* strains supports immune modulation, but direct evidence specifically on DSM 6595 is limited. It shows potential for balancing immune responses.

Is it safe?

Yes, *Lactobacillus plantarum* DSM 6595 is considered safe with no significant adverse effects reported in clinical studies or regulatory assessments.

How long does it take to see effects?

Changes in cytokine levels may occur within weeks of consistent use. The strain can persist in the gut for about 11 days after supplementation.

Does it survive stomach acid?

Yes, *Lactobacillus plantarum* DSM 6595 has demonstrated its ability to survive passage through the gastrointestinal tract and adhere to intestinal cells.

Is it proven to reduce infections?

While some related strains show potential in reducing pathogenic microorganisms, direct evidence for DSM 6595 reducing infections is inconclusive and requires more large-scale randomized controlled trials.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC8019694/ – This meta-analysis of 18 RCTs on *L. plantarum* strains found significant reductions in pro-inflammatory cytokines (IL-4, TNF-α, IFN-γ) and increases in anti-inflammatory IL-10. It highlights the immunomodulatory potential of the species, though specific focus on DSM 6595 was not isolated.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2646346/ – This pilot RCT in ICU patients investigated *L. plantarum* 299 (related to DSM 6595) and found no significant differences in inflammatory markers or microbiological findings. The study was small and had limited power, suggesting the need for larger trials.
https://www.efsa.europa.eu/en/efsajournal/pub/1726 – This EFSA Scientific Opinion recognizes *L. plantarum* 299 (DSM 6595) as safe and supports health claims related to reducing pathogenic intestinal microorganisms. It provides an authoritative regulatory assessment of the strain's safety and some efficacy.
https://microbiomepost.com/probiotic-strains/lactiplantibacillus-plantarum-6595/ – This source provides general information about *Lactiplantibacillus plantarum* 6595, including its ability to persist in the intestine for up to 11 days post-intake and its mannose-dependent adhesion mechanism, which is crucial for its interaction with the host.