Get Your Personalized Supplement StackSupplement Stack Quiz

Lactobacillus Plantarum Lp115

Also known as: Lactiplantibacillus plantarum Lp-115, Lactobacillus plantarum Lp-115, Lp-115, L. plantarum Lp-115

Overview

*Lactiplantibacillus plantarum* Lp-115, formerly known as *Lactobacillus plantarum* Lp-115, is a specific strain of lactic acid bacteria used as a probiotic supplement. It is naturally found in fermented foods and the human gastrointestinal tract. This Gram-positive, facultative anaerobic bacterium is valued for its ability to survive gastric transit and colonize the gut. Lp-115 is primarily used to support gut health, modulate immune function, and potentially reduce inflammation. Research suggests it can reduce pro-inflammatory cytokines and enhance beneficial gut bacteria. While general *L. plantarum* effects are well-documented, strain-specific evidence for Lp-115 is still emerging, with moderate research maturity and good quality evidence supporting its potential benefits.

Benefits

*Lactiplantibacillus plantarum* Lp-115 offers several potential health benefits, primarily related to gastrointestinal health and immune modulation. In vitro and in vivo studies suggest that Lp-115 can reduce *Helicobacter pylori* adhesion and gastric inflammation by reducing pro-inflammatory cytokines like IL-8 and TNF-α. Meta-analyses of *L. plantarum* (though not strain-specific) indicate a statistically significant reduction in IL-4, suggesting immune regulation. *L. plantarum* strains have also been shown to increase beneficial gut bacteria and decrease harmful species, contributing to microbiota restoration. Individuals with GI distress or *H. pylori* infection may experience reduced inflammation and improved gut barrier function. The clinical significance is likely modest but statistically significant, with some immune and inflammatory markers improving within weeks.

How it works

*Lactiplantibacillus plantarum* Lp-115 exerts its effects through several biological pathways. It modulates the immune system by reducing pro-inflammatory cytokines (IL-8, TNF-α) and modulating anti-inflammatory cytokines (IL-4, IL-10). In the gastrointestinal tract, it colonizes the gut, competes with pathogens, and strengthens the gut barrier function. *Lp-115* enhances beneficial gut bacteria and suppresses pathogenic species, contributing to a balanced gut microbiota. It reduces *H. pylori* adhesion to gastric cells. As a probiotic, it acts locally in the gut, requiring viable bacteria for efficacy and is not absorbed systemically.

Side effects

*Lactiplantibacillus plantarum* Lp-115 is generally recognized as safe (GRAS) for healthy adults. Common side effects, occurring in more than 5% of individuals, include mild gastrointestinal symptoms such as bloating and gas. Uncommon side effects (1-5%) may include mild diarrhea or constipation. Rare side effects (less than 1%) involve very rare reports of systemic infection in immunocompromised individuals. No significant drug interactions have been reported, but caution is advised in immunocompromised patients. Contraindications include severe immunodeficiency, recent surgery, or critical illness. While considered safe for most adults, there is insufficient data for pregnant or breastfeeding women, warranting caution in these populations.

Dosage

The minimum effective dose of *Lactiplantibacillus plantarum* Lp-115 is not well-established, but general *L. plantarum* doses range from 1–10 billion CFU/day. An optimal dosage range of 5–10 billion CFU/day is commonly used in studies. Up to 50 billion CFU/day has been used safely in clinical trials, but higher doses are not recommended without medical supervision. It is best taken with meals to enhance survival through gastric transit. Capsules or powders with enteric coating may improve viability. Viability depends on the strain, formulation, and gastric pH. Prebiotics may enhance colonization.

FAQs

How should I store *Lactiplantibacillus plantarum* Lp-115?

Refrigerate if recommended by the manufacturer to maintain viability. Check the product label for specific storage instructions to ensure the probiotic remains effective.

When is the best time to take *Lactiplantibacillus plantarum* Lp-115?

Take it with meals to improve survival through gastric transit. Food can help buffer the probiotic against stomach acid, increasing its chances of reaching the intestines.

What results can I expect from taking *Lactiplantibacillus plantarum* Lp-115?

It may reduce bloating, improve stool consistency, and support gut barrier function. You might also experience a modest reduction in inflammatory markers, indicating improved immune modulation.

Is *Lactiplantibacillus plantarum* Lp-115 safe for immunocompromised individuals?

Consult a healthcare provider before use. While generally safe, immunocompromised individuals may be at a higher risk of systemic infection and should seek medical advice.

Are all probiotics the same?

No, not all probiotics are equal. The strain, dose, and formulation matter significantly. Different strains have different effects, so choose a probiotic that is specifically suited to your needs.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC10445763/ – This in vitro and in vivo study examined the effects of *Lactiplantibacillus plantarum* Lp-115 on *H. pylori* inhibition. The key findings indicated that Lp-115 reduced *H. pylori* adhesion and inflammation, as well as lowered IL-8 and TNF-α levels in cell culture and mouse models, suggesting a potential mechanism for its anti-inflammatory effects in the gut.
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.643420/full – This meta-analysis of randomized controlled trials investigated the impact of *Lactobacillus plantarum* on immunity. The results showed that *L. plantarum* reduced IL-4 levels, indicating a statistically significant effect on immune regulation, though it's important to note that the analysis was not strain-specific and included various *L. plantarum* strains.
https://academic.oup.com/lambio/article/74/6/949/6989151 – This experimental study focused on the probiotic characterization of *Lactiplantibacillus plantarum* HOM3204 in an animal model. The study found that *L. plantarum* restored gut microbiota by increasing beneficial bacteria, providing mechanistic insight into its potential to improve gut health, although the findings are limited by the fact that it was not a human study and not strain-specific to Lp-115.
https://www.mdpi.com/2072-6643/15/16/3551 – This study provides a comprehensive review of the health benefits of *Lactiplantibacillus plantarum*, highlighting its role in gut health, immune modulation, and potential applications in various diseases. It emphasizes the importance of strain-specific research to fully understand the diverse effects of different *L. plantarum* strains.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10931784/ – This review discusses the potential benefits of probiotics, including *Lactiplantibacillus plantarum*, in managing symptoms of neurodegenerative diseases. While the evidence is preliminary and not strain-specific, it suggests that certain probiotics may play a role in symptom management through gut-brain axis modulation.