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Lactobacillus Plantarum Lp90

Also known as: Lactobacillus plantarum, Lp90, Lactobacillus plantarum Lp90

Overview

Lactobacillus plantarum Lp90 is a specific strain of lactic acid bacteria, a type of probiotic commonly found in fermented foods and the human gut. As a probiotic supplement, Lp90 is primarily utilized for its potential to modulate the gut microbiota, thereby supporting digestive health. Probiotics like Lp90 are also being investigated for their influence on metabolic functions and immune responses. While the broader species *Lactobacillus plantarum* has been extensively studied with numerous randomized controlled trials and meta-analyses, strain-specific research for Lp90 is less abundant compared to other well-known strains such as Lp299v. The existing evidence, however, suggests that Lp90 shares many of the beneficial characteristics attributed to the *Lactobacillus plantarum* species, with research quality ranging from well-conducted RCTs to systematic reviews.

Benefits

Research on *Lactobacillus plantarum* strains, including Lp90, indicates several potential benefits. A meta-analysis of nine randomized controlled trials (RCTs) on various *L. plantarum* strains suggested potential improvements in metabolic health, including reductions in body weight, BMI, and visceral fat, as well as positive effects on blood glucose and inflammatory markers. The efficacy of these benefits can depend on specific strain combinations and demographic factors. Furthermore, studies, primarily in animal models, have shown that *L. plantarum* administration can significantly modulate gut microbiota composition by increasing beneficial bacteria like *Bifidobacterium* and *Lactobacillus* while decreasing potentially pathogenic species, leading to enhanced microbial diversity and richness during supplementation. Although direct evidence for Lp90's effect on iron absorption is limited, a systematic review and meta-analysis focusing on the related strain *L. plantarum* 299v demonstrated a significant increase in iron absorption in humans (standardized mean difference 0.55, 95% CI 0.22–0.88, p=0.001), suggesting a broader potential for *L. plantarum* species to improve iron status.

How it works

Lactobacillus plantarum Lp90 exerts its beneficial effects primarily through several key mechanisms within the gut. It modulates the composition of the gut microbiota by competitively excluding pathogenic bacteria and promoting the growth of beneficial species. This strain produces lactic acid and bacteriocins, which contribute to an unfavorable environment for harmful microbes. Lp90 also interacts with the gut-associated lymphoid tissue, influencing immune responses and potentially reducing inflammation. By altering microbial diversity and abundance, it can improve the integrity of the gut barrier function and positively impact metabolic parameters. It's important to note that colonization and beneficial effects are generally transient, persisting only during the period of supplementation and diminishing after cessation.

Side effects

Lactobacillus plantarum Lp90 is generally recognized as safe (GRAS) and has not been associated with significant adverse effects in clinical trials. Any reported side effects are typically mild and rare, primarily involving transient gastrointestinal discomfort such as bloating or gas. There are no major drug interactions or contraindications specifically documented for Lp90. While safety in special populations, such as immunocompromised individuals, always warrants cautious evaluation, no specific concerns have been reported for Lp90 in these groups. Overall, Lp90 exhibits a favorable safety profile consistent with other well-studied probiotic strains.

Dosage

Specific dosing guidelines for Lactobacillus plantarum Lp90 are not yet well-established in clinical research. However, typical probiotic doses for *Lactobacillus plantarum* strains generally range from 10^8 to 10^10 Colony Forming Units (CFU) per day. The duration of supplementation in studies varies widely, from as short as two weeks to several months, depending on the specific health indication being investigated. The optimal dosage for Lp90 may also depend on the particular formulation (e.g., capsules, powders) and the desired health outcome. Co-administration with prebiotics, which are non-digestible food ingredients that stimulate the growth of beneficial bacteria, may potentially enhance the colonization and efficacy of Lp90. It is advisable to follow the manufacturer's recommendations or consult a healthcare professional for personalized dosing advice.

FAQs

Is Lp90 effective for weight loss?

Evidence from *L. plantarum* strains suggests modest reductions in weight and fat. However, specific high-quality data for Lp90's direct impact on weight loss are currently limited.

Does Lp90 improve iron absorption?

Direct evidence for Lp90 is lacking. However, a related strain, *L. plantarum* 299v, has been shown to significantly improve iron absorption in humans.

Is Lp90 safe to take?

Yes, Lp90 is generally recognized as safe (GRAS) with minimal and rare side effects, typically mild gastrointestinal discomfort. No major drug interactions are reported.

How long does it take to see benefits from Lp90?

Changes in gut microbiota can occur within a few weeks of consistent supplementation. More significant metabolic benefits may require longer periods of supplementation, often several months.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC11276845/ – This meta-analysis of nine randomized controlled trials (RCTs) investigated the effects of *Lactobacillus plantarum* strains on metabolic parameters. It found that *L. plantarum* supplementation could reduce BMI, visceral fat, and improve blood glucose and inflammatory markers, although the effects were influenced by specific strain combinations and demographics. The study highlights the potential of *L. plantarum* in metabolic health, despite heterogeneity across studies.
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.712236/full – This narrative review, primarily based on animal models, explored how *Lactobacillus plantarum* alters gut microbiota composition. It concluded that *L. plantarum* increases beneficial bacteria (e.g., *Bifidobacterium*, *Lactobacillus*) and reduces pathogens, thereby enhancing microbial diversity and richness. The review provides mechanistic insights into the probiotic's role in gut health, though findings are inferred for Lp90 from animal data.
https://pubmed.ncbi.nlm.nih.gov/31816981/ – This systematic review and meta-analysis, compliant with PRISMA guidelines, focused on *Lactobacillus plantarum* 299v and its impact on iron absorption. Analyzing eight studies with 950 human participants, it demonstrated a significant improvement in iron absorption (standardized mean difference 0.55, p=0.001) with *L. plantarum* 299v supplementation. While not specific to Lp90, this high-quality study suggests the potential for *L. plantarum* species to enhance iron status.