Lactobacillus Plantarum Mak45l23p
Also known as: Lactobacillus plantarum Mak45l23p, L. plantarum, Lactiplantibacillus plantarum Mak45l23p
Overview
Lactiplantibacillus plantarum (formerly Lactobacillus plantarum) is a gram-positive, facultative heterofermentative lactic acid bacterium commonly found in fermented foods and the human gastrointestinal tract. The specific strain Mak45l23p is a probiotic supplement recognized for its health-promoting properties. Its primary applications include modulating gut microbiota, enhancing immune function, and supporting metabolic health, with potential anti-obesity effects. This bacterium is known for its ability to survive gastrointestinal transit, adhere to intestinal mucosa, and produce antimicrobial substances. Research on L. plantarum is extensive, with numerous randomized controlled trials and meta-analyses supporting its efficacy, particularly for immune modulation and metabolic benefits, though strain-specific effects, such as for Mak45l23p, require further dedicated study.
Benefits
Lactiplantibacillus plantarum offers several evidence-based benefits. It significantly contributes to immune modulation by regulating cytokine production, as shown in a meta-analysis of 18 RCTs, which reported decreases in pro-inflammatory markers (IL-4, TNF-α, IFN-γ) and increases in anti-inflammatory IL-10, indicating enhanced host immunity (Zhao et al., 2021). For metabolic and obesity-related effects, a meta-analysis of 9 RCTs found that L. plantarum supplementation significantly reduced body weight and BMI in healthy adults, alongside improvements in abdominal fat and inflammatory markers like IL-6 and hs-CRP (Li et al., 2024). Furthermore, L. plantarum can modulate gut microbiota, increasing beneficial bacteria such as Bifidobacterium and Lactobacillus while reducing pathogenic species, thereby improving microbial diversity and overall gut health, as indicated by animal and human data (Fidanza et al., 2021). However, its efficacy for Irritable Bowel Syndrome (IBS) symptom improvement appears limited compared to other probiotics.
How it works
Lactiplantibacillus plantarum exerts its effects primarily within the gut. It modulates the immune response by interacting with gut-associated lymphoid tissue, balancing pro- and anti-inflammatory cytokines. The bacterium enhances gut barrier function and competitively excludes pathogens through the production of lactic acid and various antimicrobial peptides. It also influences the composition of the gut microbiota, promoting the growth of beneficial bacteria and increasing microbial diversity. As a live bacterium, it is poorly absorbed into the bloodstream; therefore, its beneficial effects are mediated locally in the gastrointestinal tract and through systemic immune signaling pathways initiated from the gut.
Side effects
Lactiplantibacillus plantarum is generally recognized as safe (GRAS) and exhibits excellent tolerability in healthy adults. Adverse effects are rare, with mild gastrointestinal symptoms such as bloating or gas occurring in less than 5% of users. There are no significant drug interactions reported for L. plantarum. However, caution is advised for individuals with severe immunocompromised states or critical illness, where the use of any probiotic should be carefully considered and discussed with a healthcare professional due to potential risks of infection, although such events are exceedingly rare with L. plantarum. No other specific contraindications have been identified for healthy individuals.
Dosage
Effective doses of Lactiplantibacillus plantarum in clinical trials typically range from 1×10^9 to 1×10^11 Colony Forming Units (CFU) per day. The duration of supplementation varies widely depending on the specific health indication, with studies lasting from two weeks to several months. While there is no established maximum safe dose, doses exceeding 10^11 CFU/day have not consistently demonstrated additional benefits and may potentially increase the likelihood of mild gastrointestinal side effects. The efficacy can also be influenced by the specific strain formulation and whether it is part of a multi-strain probiotic product. It is recommended to follow product-specific guidelines or consult a healthcare professional for personalized dosage advice.
FAQs
Is L. plantarum Mak45l23p effective for weight loss?
General L. plantarum strains have shown promise in reducing body weight and BMI in healthy adults, as supported by meta-analyses. While specific data for the Mak45l23p strain are limited, the broader evidence suggests potential benefits.
Can it improve immunity?
Yes, meta-analyses confirm that L. plantarum can modulate the immune system by decreasing pro-inflammatory cytokines and increasing anti-inflammatory ones, thereby enhancing host immunity.
Is it safe for daily use?
Yes, L. plantarum is generally recognized as safe and well-tolerated by healthy adults, with minimal and rare side effects such as mild bloating or gas.
How long does it take to see benefits?
Immune and metabolic benefits from L. plantarum supplementation typically become noticeable within weeks to a few months of consistent daily use.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8019694/ – This meta-analysis of 18 randomized controlled trials investigated the immunomodulatory effects of L. plantarum. It concluded that L. plantarum significantly regulates cytokine profiles, reducing pro-inflammatory markers (IL-4, TNF-α, IFN-γ) and increasing anti-inflammatory IL-10, thereby enhancing host immunity across various clinical populations.
- https://pubmed.ncbi.nlm.nih.gov/39062848/ – This meta-analysis of 9 randomized controlled trials focused on the metabolic and anti-obesity effects of L. plantarum in healthy adults. The study found significant reductions in body weight, BMI, abdominal fat, and inflammatory markers (IL-6, hs-CRP), suggesting L. plantarum's potential in managing metabolic health and obesity.
- https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.712236/full – This review article synthesized findings from animal and human studies regarding L. plantarum's impact on gut microbiota. It highlighted L. plantarum's ability to improve gut microbiota diversity and composition by increasing beneficial bacteria like Bifidobacterium and Lactobacillus, while reducing pathogenic species, contributing to overall gut health.
- https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.859967/full – This network meta-analysis evaluated the efficacy of various probiotics, including L. plantarum, for irritable bowel syndrome (IBS) symptom improvement. It concluded that L. plantarum ranked lower than other probiotics for IBS, suggesting limited efficacy in this specific indication compared to other available options.
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