Lactobacillus Plantarum Wcfs1
Also known as: Lactobacillus plantarum DSM 15312, Lactobacillus plantarum WCFS1, Lactobacillus plantarum Wcfs1, Lactobacillus plantarum
Overview
Lactobacillus plantarum is a species of lactic acid bacteria widely recognized for its presence in fermented foods such as sauerkraut, kimchi, and sourdough bread. The DSM 15312 strain, particularly, is renowned for its probiotic properties, promoting gut health and supporting the immune system. Its ability to survive the gastrointestinal tract, produce lactic acid, and interact with immune factors underscores its therapeutic potential. Research has shown that this strain can contribute positively to metabolic health and may be beneficial in managing conditions such as diabetes and autoimmune diseases. Clinical studies, including randomized controlled trials, validate its health-promoting properties, making it a significant probiotic choice for enhancing overall wellness.
Benefits
Lactobacillus plantarum DSM 15312 offers several research-supported benefits. Clinical studies indicate it effectively reduces fasting plasma glucose and hemoglobin A1c levels in individuals with type 2 diabetes, showcasing its role in metabolic health. The strain also demonstrates immune modulation, where it decreases pro-inflammatory cytokines and enhances anti-inflammatory responses, thus potentially lowering the incidence of common colds. Specific populations, particularly children with celiac disease, may experience marked benefits from its immune-enhancing effects. The research is robust, with statistically significant findings on both metabolic and immune-regulating properties, establishing Lactobacillus plantarum as a valuable probiotic.
How it works
Lactobacillus plantarum DSM 15312 modulates immune responses primarily by regulating cytokine production. It lowers levels of pro-inflammatory cytokines, such as IFN-γ, TNF-α, and IL-4, while promoting the production of IL-10, an anti-inflammatory cytokine. This strain interacts significantly with gut-associated lymphoid tissue and various T cell subsets, facilitating systemic immune modulation. Its ability to endure gastrointestinal transit is critical for effective colonization and exertion of its beneficial effects in the gut.
Side effects
Lactobacillus plantarum DSM 15312 is generally considered safe, with few adverse effects reported in scientific studies. Most investigations do not report common side effects occurring in more than 5% of participants, and rare side effects have not been documented. Importantly, significant drug interactions have not been identified. Nonetheless, caution is advised for individuals with compromised immune systems, as they may be at greater risk. Pregnant or breastfeeding women, along with those suffering from severe immune deficiencies, should consult healthcare providers prior to usage to ensure safety and suitability.
Dosage
The typical recommended dosage for Lactobacillus plantarum DSM 15312 ranges from 10^9 to 10^10 colony-forming units (CFU) daily, where the minimum effective dose is identified as 10^9 CFU. Although no maximum safe dosage has been established, consistent daily intake is encouraged for optimal results. Higher dosages above 10^10 CFU are not as extensively researched. This probiotic can be taken at any time of the day; however, maintaining a regular intake schedule is advised to maximize health benefits. Available forms of this strain include capsules, tablets, and powders, and storage conditions should be managed to maintain viability, with products featuring enteric coatings preferred for enhanced gastrointestinal absorption.
FAQs
Is Lactobacillus plantarum safe?
Yes, it is generally safe for consumption, but those with compromised immune systems should consult healthcare providers.
When should I take it?
It can be taken anytime, but consistency in daily dosing is recommended for best results.
What results can I expect?
Users may experience improved glucose and lipid metabolism, enhanced immune function, and decreased incidence of colds.
Is it a cure for diseases?
No, it offers supportive benefits for gut health and immune function but is not a disease cure.
Research Sources
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007192/ – This meta-analysis highlights Lactobacillus plantarum's effectiveness in improving gastrointestinal health and immune function based on several controlled trials. The results demonstrated significant benefits for conditions such as diarrhea and metabolic syndromes, especially in certain populations.
- https://www.frontiersin.org/articles/10.3389/fmicb.2019.02680/full – In this systematic review, the authors discuss the roles of Lactobacillus plantarum in disease modulation via immune response regulation and metabolic health improvements, particularly in type 2 diabetes patients. The findings were robust, showing consistent positive outcomes across studies.
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