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Lactobacillus Rhamnosus 6594

Also known as: Lactobacillus rhamnosus, Lactobacillus rhamnosus GG, Probiotic bacteria, Lactobacillus GG

Overview

Lactobacillus rhamnosus is a species of lactic acid bacteria that is commonly found in fermented foods and the human gut. It is a well-studied probiotic known for its ability to adhere to intestinal epithelial cells and survive passage through the gastrointestinal tract. Primarily, it is used to support gut health, prevent antibiotic-associated diarrhea, and potentially aid in immune system modulation. Available in various forms, including capsules, tablets, and fermented foods, Lactobacillus rhamnosus is generally considered safe for consumption. Research indicates that its benefits can vary based on specific applications and populations, with high-quality evidence supporting its use in certain contexts. The most commonly studied strain is Lactobacillus rhamnosus GG.

Benefits

Lactobacillus rhamnosus is effective in preventing antibiotic-associated diarrhea in both children and adults, supported by multiple clinical trials and meta-analyses. Studies show it can reduce the duration of diarrhea in acute gastroenteritis, particularly in European populations. Research indicates an effect size of approximately 0.85 days reduction in diarrhea duration (95% CI -1.15 to -0.56). Additionally, Lactobacillus rhamnosus may promote oral tolerance in children with cow's milk allergy, although the evidence is based on a limited number of studies. Benefits from supplementation can typically be observed within a few days.

How it works

Lactobacillus rhamnosus modulates the gut microbiota, enhancing barrier function and interacting with the immune system. It primarily affects the gastrointestinal tract and immune system by adhering to intestinal epithelial cells, influencing local immune responses. This probiotic survives passage through the stomach and small intestine to colonize the large intestine, where it exerts its beneficial effects. Its mechanism of action involves complex interactions with the host's immune cells and gut flora, promoting a balanced and healthy gut environment.

Side effects

Lactobacillus rhamnosus is generally considered safe for use in healthy individuals. Common side effects, occurring in more than 5% of users, include mild gastrointestinal symptoms such as bloating or gas. Uncommon side effects (1-5%) are not consistently reported. Rare side effects (less than 1%) include the potential for systemic infections in severely immunocompromised individuals. No significant drug interactions have been reported. It is contraindicated in severely immunocompromised individuals, and caution is advised in critically ill patients or those with compromised immune systems. Overall, the safety profile is favorable, but vigilance is necessary in vulnerable populations.

Dosage

The minimum effective dose of Lactobacillus rhamnosus is typically ≥10^9 CFU (colony-forming units) per day, with optimal dosage ranges between 10^9 and 10^10 CFU per day. While the maximum safe dose is not well-defined, doses up to 10^10 CFU are commonly used. It is best taken with food to enhance survival through the stomach. Lactobacillus rhamnosus is available in capsules, tablets, or as part of fermented foods. Survival through the gastrointestinal tract is crucial for efficacy. No specific cofactors are required for its function.

FAQs

How should I store Lactobacillus rhamnosus?

Ensure proper storage to maintain viability. Follow the storage instructions on the product label, typically recommending refrigeration or a cool, dry place.

Is Lactobacillus rhamnosus safe for everyone?

Generally safe, but caution is advised in immunocompromised individuals. Consult a healthcare provider before use if you have a compromised immune system.

When is the best time to take Lactobacillus rhamnosus?

It is best taken with meals to enhance survival through the stomach and improve its effectiveness in colonizing the gut.

What results can I expect from taking Lactobacillus rhamnosus?

May reduce diarrhea duration and prevent antibiotic-associated diarrhea. Individual results can vary based on the specific strain and overall health.

Are all probiotics the same?

No, not all probiotics are created equal; strain-specific effects are important. Lactobacillus rhamnosus has specific benefits supported by research, distinct from other probiotics.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/26365389/ – This systematic review with meta-analysis examined the effectiveness of Lactobacillus rhamnosus in preventing antibiotic-associated diarrhea in adults and children. The study found that Lactobacillus rhamnosus is effective in preventing this condition, although there was heterogeneity in study designs. The high-quality evidence supports its efficacy for this specific application.
https://pubmed.ncbi.nlm.nih.gov/31025399/ – This systematic review with meta-analysis focused on children with acute gastroenteritis and the impact of Lactobacillus rhamnosus on the duration of diarrhea. The study concluded that Lactobacillus rhamnosus reduces the duration of diarrhea, particularly in European populations. The quality of evidence was moderate to high due to heterogeneity among the included studies.
https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2021.727127/full – This meta-analysis investigated the effect of Lactobacillus rhamnosus on children with cow's milk allergy, specifically its ability to enhance oral tolerance. The findings suggest that Lactobacillus rhamnosus may indeed enhance oral tolerance in these children. However, the quality of the assessment was moderate due to the limited number of studies included.
https://www.nmi.health/lactobacillus-rhamnosus-gg-a-review-of-clinical-use-and-efficacy/ – This review provides an overview of the clinical use and efficacy of Lactobacillus rhamnosus GG. It highlights the probiotic's ability to adhere to intestinal epithelial cells and survive passage through the gastrointestinal tract, supporting its role in gut health and immune modulation. The review emphasizes the importance of strain-specific effects in probiotic research.
https://connect.h1.co/article/725785101 – This article discusses the benefits of Lactobacillus rhamnosus GG, focusing on its role in preventing antibiotic-associated diarrhea and supporting gut health. It highlights the importance of proper storage to maintain viability and the need for caution in immunocompromised individuals. The article also emphasizes that not all probiotics are the same, and strain-specific effects are crucial.