Lactobacillus rhamnosus LBV96
Also known as: Lactobacillus rhamnosus LbV 96, L. rhamnosus LbV 96, Probiotic strain LbV 96
Overview
*Lactobacillus rhamnosus* LbV 96 is a specific strain of the probiotic bacterium *Lactobacillus rhamnosus*, naturally found in the human gut. It is primarily used to support gut health, prevent or treat gastrointestinal disorders, and maintain vaginal health. This strain is known for its ability to adhere to intestinal epithelial cells and produce antimicrobial substances. Research on this strain is moderate, with several randomized controlled trials (RCTs) and meta-analyses evaluating its efficacy. The evidence is generally of moderate to high quality, with well-designed RCTs and systematic reviews, although some studies have limitations such as small sample sizes and heterogeneity.
Benefits
*Lactobacillus rhamnosus* LbV 96 offers notable benefits, particularly for vaginal health. A meta-analysis indicated a significant reduction in the Nugent score, demonstrating improved vaginal microbial patterns (SMD -0.561, 95% CI: -0.935 to -0.186, P = 0.004). Related strains, such as *L. rhamnosus* GG, have shown promise in reducing antibiotic-associated diarrhea in children (RR: 0.48, 95% CI: 0.26-0.89). While direct evidence for LbV 96 in gastrointestinal health is limited, related strains have shown mixed results in treating acute gastroenteritis, with some studies suggesting a reduction in the duration of diarrhea (MD: -0.85 days, 95% CI: -1.15 to -0.56). These benefits are particularly relevant for women with vaginal dysbiosis.
How it works
*Lactobacillus rhamnosus* LbV 96 works by colonizing the gut and vaginal mucosa, producing antimicrobial substances, and enhancing the barrier function of epithelial cells. It interacts with the immune system by modulating cytokine production and enhancing the integrity of the epithelial lining. The strain adheres to intestinal and vaginal epithelial cells and produces compounds like lactic acid and other antimicrobial peptides. After oral ingestion, it colonizes the gastrointestinal tract and translocates to the vaginal area through the gut-vagina axis.
Side effects
Generally, *Lactobacillus rhamnosus* LbV 96 is considered safe, with few reported side effects. Common side effects (>5%) are not consistently reported across studies. Uncommon side effects (1-5%) may include mild gastrointestinal symptoms such as bloating or gas. Rare side effects (<1%) can include infections in immunocompromised individuals, though serious adverse effects are rare. No significant drug interactions have been reported, but caution is advised in patients with compromised immune systems. It is generally contraindicated in severely immunocompromised individuals. Pregnant women, breastfeeding women, and children should consult healthcare providers before use.
Dosage
While a minimum effective dose for *L. rhamnosus* LbV 96 is not specifically established, related strains like *L. rhamnosus* GG have shown efficacy at doses of ≥10^10 CFU/day. Typical dosage ranges are between 10^9 to 10^10 CFU/day. There is no established maximum safe dose, but doses above 10^10 CFU/day are not commonly studied. It can be taken at any time, but it is often recommended with meals to enhance probiotic survival. Available in capsule, tablet, or powder form, it is important to choose a form that ensures the viability of the probiotic. Enteric coating or delayed-release formulations can enhance survival through the gastrointestinal tract.
FAQs
Is *L. rhamnosus* LbV 96 safe?
Generally, it is safe, but if you are immunocompromised or have severe underlying health conditions, consult a healthcare provider before use.
When and how should I take *L. rhamnosus* LbV 96?
It can be taken at any time, but it is preferable to take it with meals to enhance survival of the probiotic in the gastrointestinal tract.
What results can I expect from taking *L. rhamnosus* LbV 96?
You can expect potential improvement in vaginal microbial patterns and a possible reduction in gastrointestinal symptoms. Individual results may vary.
Is *L. rhamnosus* LbV 96 a cure for all gut and vaginal problems?
It is not a cure-all for all gastrointestinal or vaginal issues. Individual results can vary, and it should be used as part of a comprehensive approach to health.
Research Sources
- https://www.ingentaconnect.com/content/wagac/bm/2019/00000010/00000005/art00001?crawler=true&mimetype=application%2Fpdf – This meta-analysis of three double-blind RCTs involving 118 women with vaginal dysbiosis found a significant reduction in the Nugent score after oral administration of *L. rhamnosus* LbV 96, indicating an improvement in vaginal microbial pattern. The study highlights the potential of this probiotic strain in managing vaginal dysbiosis, though the small number of studies and participants limits the strength of the conclusions.
- https://pubmed.ncbi.nlm.nih.gov/26365389/ – This systematic review and meta-analysis of 12 RCTs involving 1499 participants (children and adults) found that *L. rhamnosus* GG reduced the risk of antibiotic-associated diarrhea in children. The review suggests that *L. rhamnosus* GG is effective in preventing antibiotic-associated diarrhea in children, but the low quality of evidence for adults and significant heterogeneity across studies warrant further investigation.
- https://pubmed.ncbi.nlm.nih.gov/31025399/ – This systematic review and meta-analysis of 18 RCTs involving 4208 children found that *L. rhamnosus* GG reduced the duration of diarrhea in children with acute gastroenteritis. The review indicates that *L. rhamnosus* GG may be beneficial in reducing the duration of diarrhea in children, but the high heterogeneity and methodological limitations of the included studies suggest the need for more rigorous research.
- https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2021.727127/full – This article discusses the use of probiotics, including *L. rhamnosus*, for the prevention of infections in children. It highlights the potential benefits of probiotics in preventing various infections, but also emphasizes the need for further research to determine the optimal strains and dosages for specific conditions.
- https://pubmed.ncbi.nlm.nih.gov/31012733/ – This study investigates the effects of probiotics on vaginal health. It provides evidence supporting the use of *L. rhamnosus* for improving vaginal microbial patterns and reducing the risk of vaginal infections.
Supplements Containing Lactobacillus rhamnosus LBV96
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