Lactobacillus Rhamnosus Lgg
Also known as: *Lactobacillus rhamnosus* LGG, LGG, *Lactobacillus rhamnosus* GG
Overview
*Lactobacillus rhamnosus* GG (LGG) is a well-characterized probiotic strain known for its resilience and effectiveness in various gastrointestinal conditions. It is generally used in probiotic supplements and some fermented foods, despite not being commonly found in natural environments. LGG is extensively researched, recognized for its ability to survive the harsh conditions of the gastrointestinal tract, making it effective in treating and preventing disorders such as antibiotic-associated diarrhea and infantile colic. With over 250 clinical trials supporting its efficacy, LGG has established a strong safety record and is utilized across diverse populations, including infants, children, and adults.
Benefits
LGG demonstrates several evidence-based benefits, particularly in treating infantile colic and preventing antibiotic-associated diarrhea. A meta-analysis identified a mean reduction of crying time by 32.59 minutes in infants with colic (95% CI: -44.19 to -21.00). In instances of antibiotic-associated diarrhea, LGG reduced the risk significantly; for children, the relative risk was 0.48 (95% CI: 0.26-0.89), while for adults on antibiotics for Helicobacter pylori eradication, it was even lower at 0.26 (95% CI: 0.11-0.59). Additionally, LGG has shown promise in improving gastrointestinal health in children with cow’s milk protein allergy and reducing respiratory infections in pre-term infants.
How it works
Lactobacillus rhamnosus GG enhances gut health primarily by modulating the gut microbiota and improving intestinal barrier function. It interacts with immune cells, influencing the production of anti-inflammatory cytokines and enhancing systemic immune responses. This probiotic strain effectively survives the digestive processes, reaching the colon and providing its benefits even at lower dosages.
Side effects
Overall, LGG is considered very safe with a low incidence of side effects. The most common reactions (>5%) are mild gastrointestinal symptoms, such as bloating or gas, but serious adverse effects are rare (<1%). There are no known significant drug interactions or contraindications. However, caution is advised for immunocompromised individuals, although no adverse effects have been noted in these cases. The probiotic has a long history of safe use in vulnerable populations, including pre-term infants and malnourished children.
Dosage
The recommended minimum effective dosage of LGG typically begins at around 1 billion CFU (colony-forming units) daily. For treating infantile colic, dosages in studies range from 1 to 10 billion CFU per day, while for antibiotic-associated diarrhea, a dosage of 1-2 billion CFU per day is common. There is no established maximum safe daily dose; however, doses up to 10 billion CFU have been used without notable adverse effects. Timing is crucial: treatment for colic should start shortly after diagnosis, and LGG is best administered concurrently with antibiotics for diarrhea. LGG is available in various forms, including capsules, powders, and fermented products.
FAQs
Is LGG safe for children?
Yes, LGG is generally safe and has been used extensively in infants and children without reported adverse effects.
How long does it take to see benefits of LGG?
For infantile colic, significant improvements can typically be observed within a few weeks of starting treatment.
Can I take LGG with antibiotics?
Yes, LGG is recommended to be taken concurrently with antibiotics to help reduce the risk of antibiotic-associated diarrhea.
Is LGG effective for preventing eczema?
No, studies have shown that LGG is ineffective in reducing the risk of eczema in infants and children.
Research Sources
- https://tp.amegroups.org/article/view/128126/html – This meta-analysis examined the efficacy of LGG in reducing crying time in infants with colic. It included four randomized controlled trials and found a significant reduction in crying time, establishing LGG as an effective treatment option.
- https://pubmed.ncbi.nlm.nih.gov/26365389/ – This meta-analysis focused on LGG's effectiveness in preventing antibiotic-associated diarrhea, summarizing data from 12 studies involving 1499 participants. The findings confirmed a reduced risk of diarrhea, especially in children.
- https://pubmed.ncbi.nlm.nih.gov/30231505/ – This study assessed LGG's role in preventing eczema through a meta-analysis of five RCTs, ultimately determining that LGG did not exhibit significant effectiveness in this area.
Supplements Containing Lactobacillus Rhamnosus Lgg
Ultra Flora Restore Dairy Free
Metagenics
Daily Balance 20 Billion CFU
Renew Life
Probiotics Healthy Weight Support 20 Billion CFU
Renew Life
Probiotics Occasional Constipation Support 20 Billion CFU
Renew Life
Colon Health
Bayer Phillips'
Synbiotic+
Ritual
Symbiotic+ Prebiotic Probiotic Postbiotic
Ritual
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