Lactobacillus Rhamnosus Lrao5
Also known as: Lactobacillus rhamnosus LRa05, LRa05 strain, Lacticaseibacillus rhamnosus LRa05
Overview
Lacticaseibacillus rhamnosus LRa05, formerly known as Lactobacillus rhamnosus LRa05, is a specific probiotic bacterial strain belonging to the Lactobacillaceae family. It is naturally present in fermented foods and the human gut microbiota, but is utilized as a supplement to modulate gut flora and support systemic health. Research indicates its potential in adjunctive therapy for Helicobacter pylori eradication, improving glycemic control in type 2 diabetes mellitus (T2DM), and alleviating gastrointestinal symptoms, particularly those related to antibiotic use. While specific systematic reviews on LRa05 are limited, emerging randomized controlled trials suggest moderate evidence for its benefits in these areas, highlighting its role in gut microbiota modulation and anti-inflammatory effects.
Benefits
LRa05 offers several evidence-based benefits, primarily in gastrointestinal and metabolic health. For gastrointestinal health, studies show LRa05 supplementation, when used alongside H. pylori eradication therapy, significantly reduces inflammatory markers (IL-6, TNF-α), neutrophil counts, and liver enzymes, suggesting anti-inflammatory and hepatoprotective effects. It also alleviates symptoms like abdominal pain, acid reflux, bloating, and diarrhea, improving patient compliance and gut microbiota diversity post-antibiotic treatment, though it did not significantly increase eradication rates. In metabolic health, a 12-week RCT in T2DM patients demonstrated that LRa05, combined with hypoglycemic drugs, significantly reduced fasting blood glucose and increased HDL cholesterol. It also beneficially modulated gut microbiota by increasing beneficial Bifidobacterium and reducing harmful Bacillota species. These effects are supported by controlled trials, indicating moderate evidence quality.
How it works
LRa05 exerts its beneficial effects primarily through the modulation of gut microbiota composition. It promotes the growth of beneficial bacteria, such as Bifidobacterium, while suppressing pathogenic or pro-inflammatory species. This probiotic strain also reduces systemic and local inflammation by decreasing the levels of pro-inflammatory cytokines like IL-6 and TNF-α. Furthermore, LRa05 may contribute to improved gut barrier function and liver health, as evidenced by reductions in liver enzymes and pepsinogen I. The bioavailability and efficacy of LRa05 depend on the oral administration of viable colony-forming units (CFU), with clinical studies using doses around 2 × 10^10 CFU/day.
Side effects
Clinical trials involving LRa05 supplementation have reported a favorable safety profile, with no significant adverse effects observed. It has been well tolerated in adult patients with type 2 diabetes mellitus and individuals undergoing Helicobacter pylori eradication therapy. Currently, there are no known drug interactions or contraindications specifically reported for LRa05 in the available research. While other L. rhamnosus strains have established safety records, the safety of LRa05 in special populations such as children or pregnant women has not been specifically studied. As with any probiotic, individuals with compromised immune systems should consult a healthcare professional before use, though no specific warnings for LRa05 have been issued.
Dosage
Clinical studies investigating LRa05 have utilized daily oral doses of approximately 2 × 10^10 CFU (colony-forming units) of LRa05 powder. This dosage has been administered for durations such as 12 weeks in metabolic studies or throughout the course of Helicobacter pylori eradication therapy. While there is no officially established maximum safe dose, the doses used in these clinical trials appear to be both safe and effective. Timing of supplementation is typically aligned with standard treatment regimens, for example, alongside antibiotics or hypoglycemic medications. To maintain the viability of the probiotic, LRa05 products should be stored at 4 °C.
FAQs
Is LRa05 effective for H. pylori eradication?
While LRa05 may improve inflammatory markers and reduce GI symptoms during H. pylori eradication therapy, it does not significantly increase eradication rates on its own.
Can LRa05 improve blood sugar control?
Yes, when combined with hypoglycemic drugs, LRa05 has been shown to reduce fasting blood glucose and improve HDL cholesterol levels in patients with type 2 diabetes.
Is LRa05 safe to use?
Clinical trials indicate that LRa05 is well-tolerated with no significant adverse effects reported, making it generally safe for use in adults.
How long does it take to see benefits from LRa05?
Benefits in metabolic studies have been observed within 12 weeks, while symptom relief during H. pylori eradication therapy may occur more quickly.
Research Sources
- https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1450414/full – This randomized controlled trial investigated LRa05's role in H. pylori eradication. It found that LRa05 reduced inflammatory markers (IL-6, TNF-α), improved liver enzymes, and alleviated GI symptoms, though it did not significantly increase eradication rates. The study suggests anti-inflammatory and hepatoprotective effects.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC12278088/ – This RCT involving 76 T2DM patients over 12 weeks demonstrated that LRa05, when combined with hypoglycemic drugs, significantly reduced fasting glucose and increased HDL cholesterol. It also beneficially modulated gut microbiota by increasing Bifidobacterium and reducing harmful Bacillota species, indicating metabolic benefits.
- https://pubmed.ncbi.nlm.nih.gov/26365389/ – This meta-analysis on L. rhamnosus GG (a different strain) found it effective in preventing antibiotic-associated diarrhea. While not directly about LRa05, it provides context on the broader efficacy of L. rhamnosus strains in gut health, highlighting the potential for similar benefits.
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