Lactococcus Lactis Lactis R1058
Also known as: Lactococcus lactis, Lactococcus lactis subsp. lactis, L. lactis, Lactococcus lactis R1058, Lactococcus lactis subsp. lactis R1058
Overview
Lactococcus lactis subsp. lactis is a non-motile, non-sporulating bacterium widely utilized in the dairy industry for fermentation processes. This strain is notable for its homofermentative metabolism, converting sugars into lactic acid. Besides its primary role in dairy fermentation, recent research highlights its potential immunomodulatory and health-promoting properties. This strain produces primarily L-(+)-lactic acid and has been genetically modified to deliver therapeutic proteins, such as interleukin-10 (IL-10). Research into its effects is moderately advanced, showcasing promising benefits across various health-related applications, though most studies remain preclinical or limited in scope.
Benefits
Evidence suggests multiple health benefits associated with Lactococcus lactis subsp. lactis. Immunomodulation is a significant benefit; a trial demonstrated reduced cytokine production (TNF, IL-1β, IL-6) in response to inflammatory stimuli in a controlled setting. Additionally, certain studies indicate improvements in gut health and microbiota composition, which are especially notable in athletic populations, where supplementation has enhanced exercise performance and lowered muscle damage post-exertion. Overall, the effects are well-documented, particularly among healthy individuals and athletes, with various trials indicating robust benefits within short intervention periods.
How it works
Lactococcus lactis subsp. lactis interacts with the immune system by modulating cytokine responses, affecting immune signaling pathways through the action on plasmacytoid dendritic cells. This bacterium influences gut microbiota and produces beneficial proteins, such as IL-10, which help mitigate inflammatory responses. Notably, it targets a reduction in pro-inflammatory cytokines, thereby suppressing pathways associated with inflammation, which is beneficial in various health contexts.
Side effects
Lactococcus lactis subsp. lactis is generally recognized as safe (GRAS), with few case reports of opportunistic infections. While common side effects cannot be explicitly listed due to a lack of data, rare adverse effects are not documented in reputable peer-reviewed literature. Drug interactions have not been observed, and no specific contraindications are reported. However, caution is advised in individuals with weakened immune systems, as probiotics can occasionally lead to infections in such populations. Overall, the safety profile appears solid across various studies.
Dosage
Effective daily dosages of Lactococcus lactis subsp. lactis range from 10^9 to 10^10 CFU, based on clinical data. While specific timing is not emphasized in the studies, daily administration is recommended for optimal effects. Various formulations (e.g., enteric-coated capsules, freeze-dried powder) may alter absorption rates and peak effects, but they have all shown safety in established clinical thresholds. The precise maximum safe dosage remains undefined yet is indicated to be significantly above those employed in trials without adverse reactions.
FAQs
Is Lactococcus lactis safe for everyone?
Lactococcus lactis is generally safe, though individuals with compromised immune systems should consult a healthcare provider before use.
When should I take Lactococcus lactis?
It is typically administered daily, and specific timing is not essential for efficacy.
What health improvements can I expect from Lactococcus lactis?
You may experience enhanced immune function, better gut health, and improved exercise performance.
Is Lactococcus lactis a cure for health conditions?
No, it's a health supplement that supports well-being, not a cure for diseases.