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Leaf of Life

Also known as: Olive Leaf Extract, OLE, Leaf of Life (in some herbal contexts), Olea europaea Leaf Extract

Overview

Olive Leaf Extract (OLE) is a dietary supplement derived from the leaves of the olive tree, *Olea europaea*. It is rich in polyphenolic compounds, primarily oleuropein and hydroxytyrosol, which are responsible for its bioactive properties. OLE is widely recognized for its potential benefits in cardiovascular and metabolic health, including its ability to improve blood pressure, lipid profiles, and glycemic control. Beyond these primary uses, OLE also exhibits significant antioxidant and anti-inflammatory effects. Research on OLE is well-established, with numerous randomized controlled trials and meta-analyses supporting its efficacy and safety. While the term "Leaf of Life" can sometimes refer to other plants like *Kalanchoe pinnata*, in the context of scientific research and supplement use, it most commonly refers to Olive Leaf Extract due to its extensive study and documented health benefits.

Benefits

Olive Leaf Extract (OLE) offers several evidence-based benefits, primarily in cardiometabolic health. Meta-analyses of randomized controlled trials (RCTs) indicate a statistically significant reduction in triglycerides (TG) and systolic blood pressure (SBP), which are clinically relevant for cardiovascular risk reduction. For instance, studies have shown modest but consistent decreases in SBP and TG, contributing to improved cardiovascular profiles. OLE also demonstrates anti-inflammatory effects, evidenced by reductions in inflammatory markers such as hs-CRP and interleukins in some trials. While less consistent, there is some evidence of improved glycemic control, though low-dose OLE may show less benefit. Specific populations, such as postmenopausal women with osteopenia, have shown improvements in lipid profiles and inflammatory markers, and adults with prehypertension or hypertension have seen benefits in blood pressure and lipid parameters. Additionally, leaf extracts, including OLE, may help reduce exercise-induced muscle damage and oxidative stress markers. Most benefits are observed within 4 to 12 weeks of consistent supplementation.

How it works

Olive Leaf Extract (OLE) exerts its therapeutic effects primarily through its rich content of polyphenols, such as oleuropein and hydroxytyrosol. These compounds act as potent antioxidants, scavenging free radicals and reducing oxidative stress throughout the body. OLE also possesses anti-inflammatory properties by modulating the production of pro-inflammatory cytokines like IL-6 and TNF-α. In the cardiovascular system, OLE contributes to blood pressure reduction through vasodilatory effects and by improving endothelial function. It also positively influences lipid metabolism, leading to improved lipid profiles. For metabolic health, OLE may enhance glucose metabolism and insulin sensitivity. The active compounds are absorbed and metabolized, with their bioavailability influenced by gut and liver processes, allowing them to interact with various biological pathways involved in inflammation, oxidative stress, and metabolic regulation.

Side effects

Olive Leaf Extract (OLE) is generally considered safe and well-tolerated in clinical trials, with no major safety concerns reported. The most common side effect, reported in some cases, is mild gastrointestinal discomfort. Uncommon side effects (1-5% frequency) may include rare allergic reactions. There are no significant rare adverse events documented in randomized controlled trials. However, caution is advised regarding potential drug interactions. OLE may have additive effects when taken concurrently with antihypertensive medications, potentially leading to excessively low blood pressure. Similarly, it could interact with antidiabetic medications, increasing the risk of hypoglycemia. Therefore, individuals on blood pressure-lowering or blood sugar-lowering drugs should exercise caution and consult their healthcare provider before using OLE. Data on the safety of OLE in pregnant or breastfeeding women are limited, so its use in these populations is not recommended without medical supervision.

Dosage

The recommended dosage for Olive Leaf Extract (OLE) typically ranges from 250 mg to 1000 mg per day, standardized to its oleuropein content. For optimal cardiometabolic benefits, a daily dosage of 500 mg to 1000 mg appears to be effective, as supported by various studies. While no established maximum safe dose exists, doses above 1000 mg per day have not been extensively studied in clinical trials. OLE is usually administered orally, once or twice daily, and is often recommended to be taken with meals to potentially enhance the absorption and bioavailability of its active compounds. It is commonly available in capsule or tablet form, and selecting products standardized for oleuropein content ensures consistent potency. No specific cofactors are required for its efficacy.

FAQs

Is Olive Leaf Extract safe for long-term use?

Current research primarily supports the safety of OLE for up to 12 weeks. Longer-term safety data are limited, so consult a healthcare professional for extended use.

Can OLE replace blood pressure medications?

No, OLE should not replace prescribed antihypertensive medications. It may complement them, but any changes to medication should only be made under physician guidance due to potential additive effects.

How soon can benefits be expected?

Improvements in blood pressure and lipid profiles are typically observed within 4 to 12 weeks of consistent Olive Leaf Extract supplementation.

Is "Leaf of Life" synonymous with Olive Leaf Extract?

Not always. While sometimes used interchangeably in herbal contexts, "Leaf of Life" can also refer to other plants like *Kalanchoe pinnata*. The scientific evidence discussed here specifically pertains to Olive Leaf Extract.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/33874859/ – This systematic review and meta-analysis investigated the effects of leaf extracts on exercise-induced muscle damage. It found that leaf extracts significantly reduced muscle damage markers and oxidative stress at 24 hours post-exercise, although effects on antioxidant status were inconsistent. The study highlighted the heterogeneity of leaf types, including olive leaf, in contributing to these benefits.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9585795/ – This systematic review and meta-analysis of twelve randomized controlled trials examined Olive Leaf Extract's impact on cardiometabolic risk factors. It concluded that OLE supplementation significantly decreased triglycerides and systolic blood pressure with moderate quality evidence, though glycemic outcomes were inconsistent, especially at lower doses. The study supports OLE's role in cardiovascular health.
https://peerj.com/articles/11173/ – This meta-analysis focused on the effect of Olive Leaf Extract on the cardiometabolic profile in adults with prehypertension or hypertension. It confirmed significant reductions in blood pressure and lipid parameters. The study was methodologically sound, using random-effects models and appropriate controls, reinforcing OLE's potential as an adjunct for managing cardiovascular risk factors.