ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
Back

Lemon Balm Leaf Powder

Also known as: Lemon balm, Melissa, Melissa officinalis

Overview

Lemon balm (*Melissa officinalis*) is a perennial herb native to Europe and Asia, characterized by its lemon-scented leaves. It is commonly used in teas, tinctures, and as a dietary supplement. Traditionally, lemon balm has been used to alleviate symptoms of anxiety, insomnia, and digestive issues. The herb contains rosmarinic acid, a compound known for its antioxidant properties. Research interest in lemon balm has been growing, particularly regarding its potential anxiolytic and antidepressant effects. While more high-quality studies are needed, systematic reviews and meta-analyses suggest that lemon balm may be effective in reducing anxiety and depression symptoms. It is generally considered safe with minimal side effects, making it a popular choice for those seeking natural remedies for mood and sleep disturbances. Lemon balm is available in various forms, including capsules, teas, and extracts.

Benefits

Lemon balm has demonstrated potential benefits in reducing anxiety and depression symptoms. A meta-analysis indicated significant improvements in anxiety (SMD -0.98) and depression (SMD -0.47) compared to placebo. These effect sizes suggest moderate to large improvements in anxiety and smaller improvements in depression. Additionally, lemon balm may enhance cognitive function and improve sleep quality. Studies have shown benefits in both acute and chronic settings, though further research is needed to determine its effectiveness in specific populations. The benefits are typically observed within a few weeks of consistent use. While promising, more high-quality studies are needed to confirm these effects and establish optimal usage guidelines.

How it works

Lemon balm's mechanism of action is believed to involve interactions with neurotransmitter systems in the brain. Active compounds, such as rosmarinic acid, may modulate neurotransmitter activity, potentially influencing the central nervous system to reduce stress and anxiety. While the exact molecular targets are not fully elucidated, it is likely that lemon balm affects neurotransmitter pathways involved in mood regulation. Limited data is available on the specific absorption and bioavailability of its active compounds, but they are known to be absorbed when ingested. Further research is needed to fully understand the complex interactions of lemon balm within the body.

Side effects

Lemon balm is generally considered safe for most individuals, with minimal reported side effects. The most common side effect is mild gastrointestinal upset, which is rare. Uncommon and rare side effects are not well-documented. However, due to its potential effects on neurotransmitter systems, lemon balm may interact with sedatives or thyroid medications. Caution is advised for individuals with thyroid conditions, although specific contraindications are not well-established. Pregnant or breastfeeding women should consult with healthcare providers before using lemon balm. It is important to monitor for any adverse reactions and discontinue use if they occur. While generally safe, it is always prudent to exercise caution and seek professional medical advice when starting any new supplement.

Dosage

The minimum effective dose of lemon balm is not well-established, but typical dosages range from 300 to 500 mg per day. Optimal dosage ranges vary, often between 300 and 1000 mg per day, depending on the intended use. The maximum safe dose is not well-defined, and high doses are generally not recommended. For sleep benefits, it is best taken before bedtime. Lemon balm is commonly available in capsule or tea form. The bioavailability may be influenced by the form of preparation. Consistent use for several weeks is recommended to assess efficacy. No specific cofactors are required for its use.

FAQs

Can lemon balm be combined with other herbs?

Yes, lemon balm can be used with other herbs like valerian for enhanced sleep benefits. However, monitor for any interactions and consult with a healthcare provider.

Is lemon balm safe to use?

Lemon balm is generally safe, but monitor for interactions with other medications. Consult a healthcare provider if you have any underlying health conditions.

How long does it take to see results?

It is best taken consistently for several weeks to assess efficacy. You may notice improvements in anxiety and sleep quality within this timeframe.

What are the expected results from taking lemon balm?

Users may experience improvements in anxiety and sleep quality within a few weeks of consistent use. However, it is not a substitute for medical treatment for severe conditions.

Are there any misconceptions about lemon balm?

Lemon balm is not a substitute for medical treatment for severe depression or anxiety. It should be used as a complementary therapy under professional guidance.

Research Sources

  • https://pubmed.ncbi.nlm.nih.gov/34449930/ – This systematic review and meta-analysis of randomized clinical trials found that lemon balm significantly improved anxiety and depression scores compared to placebo. The study reported standardized mean differences (SMD) of -0.98 for anxiety and -0.47 for depression, indicating a notable effect, although the authors noted high heterogeneity between the included studies.
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC11510126/ – This open multicenter post-marketing surveillance study involving children with restlessness and dyssomnia showed improvements in sleep and restlessness with a combination of lemon balm and valerian. While the study suggests potential benefits, it lacked a placebo control, which limits the strength of the conclusions.
  • https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.7252 – This meta-analysis of six randomized clinical trials involving 435 participants supported the efficacy of lemon balm in reducing anxiety and depression symptoms. The authors noted limitations including the small number of trials and variability in methods, indicating a need for further high-quality research.
  • https://examine.com/research-feed/study/dVgEz1/ – This research feed summarizes a meta-analysis indicating lemon balm's efficacy in reducing anxiety and depression symptoms. It highlights the need for more robust studies due to variability in methods and the limited number of trials included in the analysis.
  • https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.6744 – This abstract discusses the potential benefits of lemon balm, particularly its anxiolytic and antidepressant effects. It emphasizes the need for further research to fully understand its mechanisms of action and to confirm its efficacy in diverse populations.

Supplements Containing Lemon Balm Leaf Powder

SeraMense plus Probiotics Chocolate by Greens First Female
58

SeraMense plus Probiotics Chocolate

Greens First Female

Score: 58/100
SeraMense plus Probiotics Greens by Greens First Female
50

SeraMense plus Probiotics Greens

Greens First Female

Score: 50/100
SeraMense plus Probiotics by Greens First Female
83

SeraMense plus Probiotics

Greens First Female

Score: 83/100
Daily Superfoods Chocolate Detox Shake by Detox Organics
68

Daily Superfoods Chocolate Detox Shake

Detox Organics

Score: 68/100
RELAXIUM CALM by RELAXIUM
63

RELAXIUM CALM

RELAXIUM

Score: 63/100
Complete PMS Rescue by Hyland's
73

Complete PMS Rescue

Hyland's

Score: 73/100
Complete PMS Rescue by Hyland's
75

Complete PMS Rescue

Hyland's

Score: 75/100
LOVE WELLNESS® SLEEPING BEAUTY® by LOVE WELLNESS®
63

LOVE WELLNESS® SLEEPING BEAUTY®

LOVE WELLNESS®

Score: 63/100
Bloat Relief+ by Perelel
68

Bloat Relief+

Perelel

Score: 68/100
Corti-Soothe Ashwagandha L-Theanine Extra Strength by 13 DAILY
78

Corti-Soothe Ashwagandha L-Theanine Extra Strength

13 DAILY

Score: 78/100

Recommended Articles

Iron-Rich Foods & Absorption Tips for Deficiency

Iron-Rich Foods & Absorption Tips for Deficiency

Iron is essential for health, with both animal and plant sources available, and absorption enhanced by Vitamin C.

Ashwagandha Liver Risk: 2025 Safety Update

Ashwagandha Liver Risk: 2025 Safety Update

Recent findings suggest a potential link between ashwagandha use and liver injury, highlighting the need for caution.

Optimal Supplement Timing for Max Absorption

Optimal Supplement Timing for Max Absorption

Optimizing supplement intake around meals and exercise significantly enhances their absorption and effectiveness.

Boost Iron Absorption: Diet & Vitamin C Tips

Boost Iron Absorption: Diet & Vitamin C Tips

Optimize iron absorption by taking iron with Vitamin C, on an empty stomach, and following best practices for supplementation.