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Hmr Lignan

Also known as: 7-HMR, 7-Hydroxymatairesinol, phytoestrogen, lignan

Overview

7-Hydroxymatairesinol (7-HMR) is a plant lignan and a type of phytoestrogen primarily derived from the knots of Norway spruce and other coniferous trees, along with trace amounts found in various plant-based foods. This compound is noted for its potential health benefits, particularly concerning metabolic syndrome, anti-cancer properties, and antifungal actions. The metabolism of 7-HMR within the body yields bioactive metabolites, notably enterolactone (ENL) and enterodiol (END), which are thought to mediate many of its health-promoting effects. Existing research shows promise, largely from animal and in vitro studies; however, there is an ongoing need for comprehensive human clinical trials to validate these findings and fully elucidate its health implications.

Benefits

Research suggests that 7-HMR may confer various health benefits. In the area of metabolic syndrome, animal studies indicate that 7-HMR can lead to weight reductions of 10-15% and fat mass decreases of 20-25% in mice subjected to high-fat diets, implying potential enhancements in metabolic processes. Moreover, meta-analyses hint at an inverse relationship between lignan intake, including 7-HMR, and the risk for certain cancers, such as breast and colorectal cancer, though prospective studies are essential for further verification. Additionally, in vitro studies have demonstrated antifungal properties of 7-HMR against various strains, with activity dependent on concentration; however, clinical evidence in humans remains limited.

How it works

The mechanism of action of 7-HMR involves its metabolism into active metabolites, primarily enterolactone (ENL) and enterodiol (END), which interact with estrogen receptors and modulate metabolic pathways associated with lipid metabolism and glucose homeostasis. These metabolites activate specific cellular pathways that affect metabolism and potentially influence cellular proliferation. Individual absorption rates of 7-HMR can vary significantly, primarily due to differing gut microbiota compositions that influence the conversion into these bioactive metabolites.

Side effects

7-HMR is generally considered safe at dietary levels, with clinical data indicating no side effects exceeding 5% occurrence. Limited information exists on rare or uncommon adverse effects, largely due to a lack of extensive human trials. Notably, there are no significant known drug interactions; however, caution is advised for individuals taking medications processed through similar metabolic pathways. Those with hormone-sensitive conditions, pregnant or breastfeeding women, and individuals with hormone-sensitive cancers should consult with healthcare professionals prior to using 7-HMR. The long-term safety profile and potential effects associated with high doses of 7-HMR in humans remain uncertain, warranting careful consideration of its intake.

Dosage

Currently, there is no established or effective dosage for 7-HMR in humans as clinical studies remain limited. Animal studies have investigated dosages ranging from several milligrams to tens of milligrams per kilogram of body weight. Due to insufficient human research, optimal therapeutic doses and maximum safety limits cannot be defined at this time. 7-HMR can be consumed in various forms, including dietary supplements and food extracts, but absorption rates may be influenced by an individual's gut microbiota. Presently, there are no specific recommendations regarding the timing or co-factors for taking 7-HMR.