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Lindera Root Extract

Also known as: Wu Yao, Uyaku, Lindera root extract, LREE, *Lindera aggregata*

Overview

*Lindera aggregata* (Sims) Kosterm. is a traditional Chinese herbal supplement primarily utilized for its root extract. Renowned for its anti-inflammatory, antioxidant, analgesic, anti-tumor, and antimicrobial properties, it has been traditionally employed for gastrointestinal disorders, abdominal pain, and as an antispasmodic remedy. The root extract is rich in bioactive compounds such as isolinderalactone, linderane, and lindenenol. While many benefits are recognized in animal models, extensive clinical evidence from human studies is still lacking. Most available research is preclinical, derived from in vitro experiments, with limited data on its efficacy and safety in human populations.

Benefits

Research indicates that *Lindera aggregata* root extract (LREE) may significantly reduce inflammation and alleviate symptoms of ulcerative colitis in animal models, engaging the IL-6/STAT3 pathway and improving T cell balance. Secondary benefits observed include anti-inflammatory effects aligned with potential protection against conditions such as alcoholic liver injury. However, while animals show clear benefits, documentation of human-specific efficacy is minimal, making it essential for further studies to substantiate these claims and identify specific populations that may benefit most.

How it works

The mechanism of action for LREE includes the inhibition of the IL-6/STAT3 signaling pathway, which is vital for regulating immune responses. This modulation involves balancing T helper 17 and regulatory T cells, thereby influencing inflammatory processes predominantly within the immune and gastrointestinal systems. While these pathways are documented, comprehensive studies on absorption and bioavailability in humans are lacking.

Side effects

Though traditionally considered safe, comprehensive safety profiles for *Lindera aggregata* remain underexplored, especially concerning formal clinical trials. Common and rare side effects are not well documented, creating a gap in the safety understanding of its use. There is a noteworthy possibility of interactions with immunomodulatory medications due to its immune-modulating effects. Special populations, such as pregnant or breastfeeding women, should seek medical advice prior to consumption due to the lack of extensive studies in these demographics. Therefore, consumers should exercise caution and consult healthcare practitioners.

Dosage

Existing animal studies suggest potential dosages ranging from 0.5 to 2 g/kg of raw herb per day. However, formal minimum effective doses for human use remain uncertain, as established dosages and maximum safe limits are absent from current research. Timing and method of intake are also not thoroughly specified, with common practice involving the use of ethanol extracts. More comprehensive studies are necessary to clarify optimal dosing recommendations for various conditions.

FAQs

What should I consider before using Lindera Root Extract?

Consult with a healthcare provider, especially if you're on other medications, as traditional use doesn’t guarantee safety.

Is it safe for long-term use?

While considered safe in traditional practices, formal long-term safety studies are lacking, warranting caution.

What are the expected benefits?

Potential benefits for gastrointestinal health have been observed in animal studies, though human data is limited.

Can it interact with other medications?

Yes, potential interactions may occur with immunomodulatory drugs due to its immune system influence.

Is there a recommended dosage?

No established dosage exists for humans; animal studies provide preliminary ranges, but further research is needed.

Research Sources

https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.615506/full – A preclinical study demonstrated that LREE moderates ulcerative colitis symptoms in mice by influencing the IL-6/STAT3 pathway, highlighting the herb's potential biological effects but underscoring the limitations of animal research.
https://osf.io/mepkc/?action=download – This systematic review discusses the biological activities of various *Lindera* species, noting potential anti-inflammatory effects, though it lacks specific insights into *L. aggregata* and human applicability.
https://www.researchgate.net/publication/386273889_A_systematic_review_of_the_essential_oils_and_biological_activities_of_the_genus_Lindera_Lauraceae – This comprehensive review outlines the diverse biological activities of *Lindera* species, including anti-inflammatory properties, but does not delineate data specifically for *L. aggregata* or related human studies.
https://www.maxapress.com/article/doi/10.48130/MPB-2023-0011 – Assessment on the traditional usage and pharmacology of *L. aggregata*, confirming limited human trial data and accentuating the need for further scientific validation.
https://www.researchgate.net/publication/7817375_Water_extract_of_the_root_of_Lindera_strychnifolia_slows_down_the_progression_of_diabetic_nephropathy_in_dbdb_mice – This research indicates that aqueous extracts of related *Lindera* species slow down diabetic nephropathy progression in mice, hinting at possible therapeutic effects but also the lack of empirical human testing.