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Lithothamnium

Also known as: Red marine algae, Lithothamnion, *Lithothamnion calcareum*

Overview

*Lithothamnion calcareum* is a type of red marine algae known for its mineral density, particularly its high content of calcium and magnesium, along with various trace elements. Typically found in marine environments, it is commonly used as a dietary supplement to enhance bone health and support vital physiological functions. With a complex mineralogical composition featuring aragonite, magnesian calcite, and calcite, *Lithothamnion calcareum* presents a unique option in mineral supplementation. Research on this ingredient indicates potential benefits for bone density, particularly in populations at risk of osteoporosis, as well as possible protective effects against colorectal cancer. Its use in dietary supplements is well-established, with evidence stemming from various studies, though human trials are limited.

Benefits

Evidence suggests multiple benefits associated with *Lithothamnion calcareum*: primary outcomes include an increase in bone mineral density (BMD) as shown in animal studies, with a significant enhancement in bone architecture. A notable human trial using Aquamin® (derived from *Lithothamnion calcareum*) indicated a 20% reduction in Ki67 expression, which is linked to reduced cellular proliferation, hinting at potential protective effects against colorectal cancer. Secondary evidence points towards a positive effect on gut health, although specific quantification was not provided. Most benefit appears to be seen in populations at risk for osteoporosis or colorectal cancer, with significant clinical relevance noted in the studies conducted.

How it works

*Lithothamnion calcareum* contributes to bone health primarily through its high calcium and magnesium content, which promotes calcium deposition and mineralization of bone. Additionally, the algae may alter gut microbial communities and associated metabolite profiles, influencing overall gut health. The reduction of Ki67 expression indicates a possible mechanism through which this supplement could impact cellular proliferation pathways, which is significant for colorectal cancer prevention.

Side effects

Overall, *Lithothamnion calcareum* is generally regarded as safe with minimal observed side effects, as evidenced by a 90-day human clinical trial that reported no significant adverse events. Common side effects were not noted, and there were no reports of uncommon or rare side effects. The reviewed research did not indicate any significant drug interactions or contraindications, suggesting a favorable safety profile. However, caution should be exercised regarding its use in special populations, such as pregnant women or individuals with severe kidney disorders, as specific studies have not evaluated its safety in these groups.

Dosage

The recommended dosage of *Lithothamnion calcareum* was evidenced in a clinical trial, which provided 800 mg of calcium daily without any reported adverse effects. This dose appears effective, although optimal ranges haven't been strictly defined in the literature. There is currently no established upper limit for safety thresholds. The supplement is typically available in capsule form, and while there are no specific recommendations for timing or administration, ensuring adequate mineral intake through this supplement could be beneficial for bone health and overall physiological functions.

FAQs

How long should I take *Lithothamnion calcareum* to see benefits?

The human trial lasted 90 days, and while benefits were noted, long-term use may be necessary for sustained effects.

Is *Lithothamnion calcareum* safe for everyone?

It is generally safe for healthy individuals and those at risk for colorectal cancer, but safety in populations like pregnant women is less studied.

What side effects should I be aware of?

No significant side effects were reported in clinical trials, indicating a good safety profile.

What results can I expect from using this supplement?

Users may expect improved bone health and possible protective effects against colorectal cancer.

Can I substitute *Lithothamnion calcareum* for medical treatment?

It is a dietary supplement and should not replace prescribed medical treatments.

Research Sources

https://www.medrxiv.org/content/10.1101/2020.12.30.20249070v1.full – This randomized controlled trial evaluated the effects of Aquamin® on healthy individuals at risk for colorectal cancer, finding significant changes in Ki67 expression related to cancer cell proliferation, though it focused primarily on safety and tolerability.
https://www.researchgate.net/publication/257463269_Preservation_of_Bone_Structure_and_Function_by_Lithothamnion_sp_Derived_Minerals – This study examined the benefits of *Lithothamnion calcareum* on bone structure and function in female mice, demonstrating improved bone mineral density and architecture, establishing its potential for bone health.
https://www.mdpi.com/2673-6497/2/2/13 – This analytical study characterized the mineral content of *Lithothamnion calcareum*, highlighting its complex mineralogical composition and rich mineral content, which supports its use in dietary supplements.