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Long Jack Root Extract

Also known as: Tongkat Ali, Malaysian Ginseng, Ali's Thunder, Long Jack, Eurycoma longifolia

Overview

Eurycoma longifolia, commonly known as Tongkat Ali, is a flowering plant native to Southeast Asia, recognized for its traditional medicinal usage. The extract from its roots contains bioactive compounds such as quassinoids and alkaloids, which are associated with various health benefits, especially in sexual health and hormone regulation. Research suggests that Tongkat Ali may enhance testosterone levels, improve sexual function, and provide ergogenic benefits, making it a popular choice for individuals looking to enhance athletic performance and male reproductive health. Despite the interest in this supplement, the quality of research is varied, highlighting a need for further investigation to establish its efficacy and safety more comprehensively.

Benefits

Research indicates that supplementation with E. longifolia can lead to notable improvements in health. A systematic review has shown a significant increase in total testosterone levels, with a standard mean difference (SMD) of 1.352, especially in hypogonadal men (p = 0.001). Additionally, improvements in sperm health markers have been reported, particularly for men with idiopathic infertility, while erectile function enhancements show promise with mixed results. The strongest evidence supports benefits for individuals with low testosterone levels, though other effects require further validation through additional research.

How it works

The bioactive compounds in E. longifolia, particularly quassinoids, are believed to modulate testosterone production by influencing the hypothalamic-pituitary-gonadal axis. This interaction promotes hormonal balance and may also improve mood and stress management. The exact molecular targets remain under investigation, but these compounds appear to activate various pathways that enhance testosterone synthesis and engage neurotransmitter systems related to stress.

Side effects

E. longifolia is generally considered safe when used at recommended dosages, with acute toxicity tests indicating an LD50 of 1500-2000 mg/kg for alcoholic extracts. Clinical studies have not shown significant adverse effects on liver or renal function at normal doses. Limited side effects have been reported, primarily anecdotal, including gastrointestinal discomfort and allergic reactions. Current literature finds no major drug interactions or confirmed contraindications; however, caution is suggested for individuals on hormone-affecting medications. The safety profile during pregnancy or lactation has not been adequately defined, requiring professional consultation before use.

Dosage

Recommended dosages for E. longifolia typically range from 50 mg to 300 mg per day, with clinical trials suggesting that the most effective dosages are between 200 mg and 300 mg. Maximum safe dosages are yet to be firmly established, but dosages up to 300 mg are generally well tolerated. Consistent daily intake is advisable, and the timing of dosage does not significantly impact efficacy. It is recommended to use standardized forms of root extract to ensure reliable bioactive content, although the influence of various extract types on absorption needs further study.

FAQs

How long does it take to see effects?

Effects on testosterone levels can typically be observed within several weeks to months of consistent supplementation.

Is it safe for long-term use?

While short-term use has not indicated significant adverse effects, long-term safety still requires more research for definitive conclusions.

Can it be used with other supplements or medications?

Caution is advised when combining E. longifolia with other medications, especially those affecting hormone levels or blood pressure.

What are the expected results?

Significant increases in testosterone levels can be anticipated, particularly in individuals with low testosterone.

Is it a cure for sexual dysfunction?

While it can enhance testosterone and has potential benefits, E. longifolia is not a cure-all for sexual dysfunction.

Research Sources

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658957/ – This systematic review provides substantial evidence of E. longifolia's efficacy in increasing testosterone levels and improving various health markers. The analysis highlights the significant improvements observed in both hypogonadal men and fertility-related parameters, underscoring the need for further research into long-term effects.
https://pubmed.ncbi.nlm.nih.gov/23349434/ – This study discusses the effects of E. longifolia on testosterone levels and male fertility, concluding that the compound shows promising benefits but requires more rigorous trials to ascertain safety and long-term efficacy.