Lophatherum Gracile Herb Extract
Also known as: Lophatherum gracile, LGBF (Total Flavonoid Content of Lophatherum gracile), Lophatherum gracile Brongn.
Overview
Lophatherum gracile Brongn. is a traditional medicinal plant recognized for its rich flavonoid content, primarily derived from its leaves. It has been used for centuries in herbal medicine, particularly for alleviating fever and treating inflammatory conditions. Recent studies have investigated its potential to support metabolic health and liver function, suggesting benefits in areas like insulin sensitivity and liver inflammation. Despite these potential benefits, current research is predominantly based on animal studies and in vitro experiments, indicating that while the initial findings are promising, more rigorous human clinical trials are necessary to confirm efficacy and establish safety. The extract is available in various forms, mostly as an herbal supplement rich in antioxidants and anti-inflammatory agents.
Benefits
Research highlights several potential benefits of Lophatherum gracile, particularly regarding its flavonoids. Animal studies show improved insulin sensitivity and reduced liver inflammation in diabetic models through the regulation of metabolic pathways such as PI3K/AKT and NF-κB. Moreover, there is evidence suggesting its possible anti-inflammatory and antioxidant properties. These benefits appear to be particularly pronounced in individuals with type 2 diabetes and those at risk of liver damage due to metabolic disorders. However, quantifiable effect sizes and clinical significance in humans remain undefined. More comprehensive clinical trials are critical to assess the actual benefits and safety when used in human populations.
How it works
Lophatherum gracile exerts its effects primarily through the modulation of the PI3K/AKT and NF-κB signaling pathways. These pathways are crucial for inflammatory response regulation and insulin signaling. By interacting with these pathways, the flavonoids in Lophatherum gracile may enhance insulin sensitivity and mitigate inflammation, particularly in hepatic tissues. However, the precise mechanisms and molecular interactions in human physiology are still not well-understood, and further investigation is needed.
Side effects
Currently, the safety profile of Lophatherum gracile is not well-documented due to limited human data. Traditionally, it has been regarded as safe, but common, uncommon, and rare side effects are not clearly established. There are potential concerns regarding interactions with diabetes medications or other herbal supplements, necessitating caution. Specific contraindications are not defined, although it is advised that pregnant or breastfeeding individuals use it cautiously due to a lack of adequate safety studies. Additionally, the use in children should be approached with caution until more information is available.
Dosage
There are no established dosage guidelines for Lophatherum gracile due to insufficient clinical data. Minimum effective, optimal, and maximum safe doses have not been determined. It is typically consumed as an extract, but specifics on timing and administration remain inconclusive. As absorption factors are not well-studied, the efficacy of various forms should be further explored in well-controlled studies. As such, it is recommended to consult healthcare professionals before use, particularly for individuals with diabetes or liver conditions.
FAQs
Is Lophatherum gracile safe for everyone?
While traditionally deemed safe, there's limited scientific data regarding its safety, especially in pregnant or breastfeeding women and children.
Can Lophatherum gracile treat diabetes?
It may enhance insulin sensitivity based on animal studies, but it is not a proven treatment for diabetes in humans.
How should I take Lophatherum gracile?
Dosage and timing have not been established; consult a healthcare provider for personalized advice.
What are the side effects of Lophatherum gracile?
Side effects are not well documented; there are no known common or rare side effects reported in studies.
What should I consider before using Lophatherum gracile?
Consult a healthcare provider, especially if you have health conditions or are taking other medications.
Research Sources
- https://onlinelibrary.wiley.com/doi/10.1155/2023/5273349 – This study explored the effects of Lophatherum gracile on metabolic disorders in diabetic mice, discovering improvements in insulin sensitivity and liver inflammation through flavonoid mechanisms. However, it emphasizes the need for human studies to validate these results.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.575803/full – Investigating the flavonoid content of Lophatherum gracile, this review outlines its antioxidant and anti-inflammatory effects based on in vitro and animal research. It notes the gap in clinical trials necessary for confirming these benefits in humans.
- https://www.researchgate.net/publication/379315869_Lophatherum_gracile_Brongn_a_review_on_phytochemistry_bioactivity_and_food_applications – This comprehensive review summarizes the phytochemistry and bioactive properties of Lophatherum gracile, including traditional applications and potential health benefits. It calls attention to the urgent need for rigorous clinical research.
- https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2125.1999.00004.x – This resource discusses the traditional uses of Lophatherum gracile and provides historical context, highlighting long-standing practices but pointing out the lack of modern scientific validations.
- https://academic.oup.com/toxres/article/doi/10.1093/toxres/tfae035/7625491 – This article addresses toxicological assessments relevant to herbal supplements, including Lophatherum gracile, indicating a need for thorough investigation on both efficacy and safety before broad recommendations can be made.
