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Loquat leaf

Also known as: Loquat leaf, Japanese plum, Chinese plum, LLE, Loquat leaf extract, Eriobotrya japonica

Overview

Loquat leaf extract (LLE) is derived from the leaves of the loquat tree (*Eriobotrya japonica*), a plant native to Asia. It is traditionally used in medicine for its potential anti-inflammatory and antioxidant properties. The extract contains bioactive compounds such as ursolic acid, which is believed to contribute to its health benefits. Emerging research explores its effects on muscle strength, allergic symptoms, and antifungal activity. LLE is available in various forms, including capsules and extracts. While some studies show promising results, more rigorous, large-scale trials are needed to establish its efficacy and safety comprehensively. The quality of available evidence is variable, highlighting the need for further research to validate its purported benefits.

Benefits

Loquat leaf extract (LLE) has shown potential benefits in several areas, though the evidence is still emerging. One study suggests that LLE may help maintain muscle strength and mass by inhibiting muscle atrophy, although this finding requires confirmation through human trials. Additionally, LLE has been suggested to relieve allergic symptoms, potentially serving as a functional food ingredient. Furthermore, in vitro studies have demonstrated antifungal activity against certain pathogens. These benefits may be particularly relevant for individuals with muscle atrophy or allergic conditions, but more research is needed to determine specific effect sizes and clinical significance.

How it works

The mechanism of action of loquat leaf extract (LLE) is primarily attributed to its bioactive compounds, particularly ursolic acid. Ursolic acid is believed to exert its effects through anti-inflammatory and antioxidant pathways. It may interact with the muscle and immune systems to prevent atrophy and alleviate allergic symptoms. Ursolic acid is known to influence various molecular targets involved in inflammation and muscle growth. However, specific data on the absorption and bioavailability of LLE components in humans remains limited, necessitating further research to fully elucidate its mechanisms of action.

Side effects

Loquat leaf extract (LLE) is generally considered safe in the doses studied, but comprehensive safety data is lacking. Common, uncommon, and rare side effects are not well-documented in available literature. Potential interactions with other medications are also not well-studied, highlighting the need for caution when combining LLE with other drugs. While no specific contraindications have been identified, caution is advised due to the limited safety data. Pregnant or breastfeeding women should consult healthcare providers before use due to the lack of comprehensive safety information in these populations. Further research is needed to fully characterize the safety profile of LLE.

Dosage

The minimum effective dose of loquat leaf extract (LLE) has not been definitively established. However, one study used 500 mg of LLE per day, containing approximately 50.94 mg of ursolic acid. The maximum safe dose is also not yet established. Typically, LLE is taken twice daily, 30 minutes after meals, often in capsule form. Bioavailability may vary based on the formulation and individual factors. There are no identified required cofactors for LLE supplementation. More research is needed to determine optimal dosage ranges and safety thresholds for different populations and conditions.

FAQs

Is loquat leaf extract safe?

While generally considered safe, comprehensive safety data is lacking. Consult a healthcare provider before use, especially if pregnant, breastfeeding, or taking other medications.

How should I take loquat leaf extract?

Typically, it is taken twice daily, 30 minutes after meals. Follow the dosage instructions on the product label or as directed by a healthcare provider.

What are the expected results from taking loquat leaf extract?

The results may vary depending on the condition being treated. Some studies suggest potential benefits for muscle strength and allergic symptoms, but more research is needed.

Are there any known drug interactions?

Potential interactions with other medications are not well-studied. Consult a healthcare provider to discuss potential interactions before use.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC5143716/ – This randomized, double-blind, placebo-controlled trial investigated the effects of loquat leaf extract on muscle strength and mass in healthy adults over 12 weeks. The key finding was that LLE may help maintain muscle strength and mass, suggesting a potential benefit for preventing muscle atrophy. However, the study had a limited sample size and duration, necessitating larger, longer-term studies to confirm these results.
https://www.mdpi.com/2313-5786/3/4/13 – This clinical trial suggests that loquat leaf supplements may relieve allergic symptoms, indicating its potential as a functional food ingredient. The study focused on individuals with allergic rhinitis. However, specific details on the methodology and sample size were not provided, requiring further verification with more detailed reporting to assess the reliability of the findings.
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.663584/full – This in vitro study demonstrated that loquat leaf extract exhibits antifungal activity against *P. digitatum*. While the in vitro results provide valuable insights into potential antifungal uses, it is important to note that these findings may not directly translate to in vivo efficacy. Further research is needed to determine the effectiveness of LLE as an antifungal agent in living organisms.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9289807/ – This study investigates the anti-inflammatory and antioxidant properties of Eriobotrya japonica (Loquat) leaf extract. The research highlights the potential of loquat leaf extract in mitigating oxidative stress and inflammation, which are key factors in various chronic diseases. The findings suggest that loquat leaf extract could be a valuable natural remedy for conditions associated with inflammation and oxidative damage.
https://onlinelibrary.wiley.com/doi/10.1155/2023/1188178 – This study explores the traditional uses, phytochemistry, and pharmacological activities of Eriobotrya japonica (Loquat). It provides a comprehensive overview of the plant's historical applications in traditional medicine and its chemical composition. The study also summarizes the various pharmacological activities attributed to loquat, supporting its potential as a source of bioactive compounds with therapeutic benefits.