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Lowat Proprietary Blend

Also known as: LOWAT®, LI10903F, Piper betle leaf extract, Dolichos biflorus seed extract, Betel leaf, Horse gram, LOWAT® (LI10903F)

Overview

LOWAT® is a proprietary herbal blend designed for weight management and metabolic support, consisting of *Piper betle* leaf extract (standardized to 6% polyphenols) and *Dolichos biflorus* seed extract (standardized to 4% γ-glutamyl phenylalanine) in a 2:3 ratio. Both components have traditional uses in Ayurvedic medicine for metabolic health. This blend is primarily marketed to support healthy glucose and lipid metabolism, promote fat breakdown, and aid in weight management. Its mechanism involves modulating key hormones like adiponectin, which enhances insulin sensitivity and fat oxidation, and ghrelin, which influences appetite. Research includes in vitro, animal studies, and one randomized, double-blind, placebo-controlled clinical trial, indicating a moderate level of research maturity. However, the evidence base is currently limited to a small number of studies, with no systematic reviews or meta-analyses specifically on LOWAT®.

Benefits

LOWAT® has demonstrated several benefits primarily related to weight management and metabolic health. In an 8-week randomized, double-blind, placebo-controlled clinical trial involving 50 overweight adults, supplementation with 300 mg of LOWAT® three times daily led to an average weight loss of 9.4 pounds, significantly more than the 3.9 pounds observed in the placebo group (p=0.00005). This suggests a clinically meaningful effect on weight reduction. Furthermore, the study showed significant improvements in metabolic hormone profiles: serum adiponectin, a hormone involved in fat metabolism and insulin sensitivity, increased by 15.35% (p=0.0076), while serum ghrelin, an appetite-stimulating hormone, decreased by 20.85% (p=0.0066). These hormonal changes support the proposed mechanism of action related to enhanced fat oxidation and appetite modulation. The trial also noted an improved lean mass ratio, indicating that the weight loss was primarily due to fat reduction rather than muscle loss. These benefits were observed in overweight adults adhering to a controlled 2,000-calorie diet within an 8-week period. The evidence for these benefits is derived from a single, moderate-quality human clinical trial, supported by preclinical data.

How it works

LOWAT® exerts its effects primarily by modulating hormones involved in energy balance and metabolism. It appears to promote fat breakdown (lipolysis) and influence appetite regulation. Specifically, the blend is thought to increase levels of adiponectin, a hormone that enhances insulin sensitivity and promotes fat oxidation, thereby improving metabolic efficiency. Concurrently, it is believed to decrease ghrelin, an appetite-stimulating hormone, which can lead to reduced food intake. The polyphenols from *Piper betle* and γ-glutamyl phenylalanine from *Dolichos biflorus* are the active components responsible for these effects, though their exact molecular targets and specific pathways are still being elucidated. The blend interacts with endocrine pathways that regulate energy expenditure and adipocyte (fat cell) metabolism.

Side effects

LOWAT® has been reported to be well tolerated in the clinical studies conducted to date, with no serious adverse events reported. There is no data indicating common, uncommon, or rare side effects in human trials. However, the overall safety assessment is based on limited short-term human data. As a proprietary herbal blend, there are no documented drug interactions, but caution is advised due to the lack of extensive research in this area. Standard precautions applicable to herbal supplements should be considered. Contraindications have not been established. Specific safety information for vulnerable populations such as pregnant or breastfeeding women, children, or individuals with pre-existing chronic diseases is not available, and therefore, its use in these groups is not recommended without medical supervision. Long-term safety data are also currently lacking.

Dosage

The recommended dosage for LOWAT® is based on the clinical trial findings, which utilized 300 mg of the blend taken three times daily, resulting in a total daily intake of 900 mg. This dosage was administered with meals in the clinical study. Currently, this is the only dosage that has been clinically studied, and therefore, optimal dosage ranges or minimum effective doses beyond this are not established. A maximum safe dose has also not been determined. The supplement was used in an encapsulated form in the studies. While the extracts are standardized for specific active compounds (polyphenols and γ-glutamyl phenylalanine), specific data on absorption factors or required cofactors are not publicly available. Users should adhere to the clinically tested dosage and timing for potential benefits.

FAQs

Is it safe?

LOWAT® appears safe and well tolerated in short-term use based on clinical studies, with no serious adverse effects reported. However, long-term safety data are currently lacking.

When should I take LOWAT®?

Based on the clinical study, LOWAT® should be taken three times daily with meals for optimal results.

How soon can I expect to see results?

Benefits from LOWAT® supplementation, including weight loss and hormonal changes, were observed within 8 weeks in the clinical trial.

Does LOWAT® suppress appetite?

The clinical study showed a decrease in ghrelin levels, an appetite-stimulating hormone, suggesting that LOWAT® may help modulate appetite, though subjective appetite data were not reported.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC3551693/ – This randomized, double-blind, placebo-controlled trial investigated the efficacy of LOWAT® in 50 overweight adults over 8 weeks. It found that the LOWAT® group experienced significantly greater weight loss (9.4 lbs vs 3.9 lbs placebo) and favorable changes in adiponectin and ghrelin levels, indicating its potential for weight management and metabolic improvement. The study concluded LOWAT® was well tolerated.
https://www.pureencapsulationspro.com/media/pdf_upload/PIS_AdipoLeanII_final.pdf – This document provides product information, including the composition of LOWAT® (Piper betle and Dolichos biflorus extracts), its primary uses for weight management and metabolic support, and highlights key characteristics such as its role in modulating adiponectin and ghrelin. It also references the clinical trial supporting its efficacy.
https://wellness.awhdallas.com/wp-content/uploads/2019/07/AdipoLean.pdf – This source offers an overview of LOWAT®, detailing its definition, natural sources, and primary applications in weight management. It emphasizes the blend's mechanism of action, particularly its influence on adiponectin and ghrelin, and summarizes the findings from the human clinical trial regarding weight loss and hormonal changes.
https://www.atriumpro.ca/media/pdf_upload/ADLII_ADL9C.pdf – This document provides further details on the clinical research supporting LOWAT®, reiterating the significant weight loss and beneficial hormonal changes observed in the 8-week human trial. It also touches upon the safety profile, noting the absence of serious adverse events, and reinforces the blend's role in promoting fat breakdown and metabolic health.
https://welltopiarx.com/product/adipolean-ii/ – This product page describes LOWAT® as a key ingredient in a weight management supplement, highlighting its benefits for fat metabolism and appetite regulation. It briefly mentions the scientific backing for its efficacy, aligning with the findings of the clinical trial on weight reduction and hormonal modulation.