Luteolin Extract
Also known as: Luteolin, 3',4',5,7-tetrahydroxyflavone
Overview
Luteolin is a naturally occurring flavonoid found in various plants like thyme, oregano, and chamomile. It's recognized for its potential health benefits stemming from its antioxidant, anti-inflammatory, and anti-cancer properties. As a dietary supplement, luteolin has been extensively studied for its biological activities, including neuroprotective effects. While research is abundant, the quality of evidence is moderate, with some studies lacking rigorous randomized controlled trial (RCT) designs or large sample sizes. Luteolin's primary uses revolve around its capacity to modulate inflammation and oxidative stress, potentially aiding in the management of various conditions. It is available in various forms, including capsules and extracts, offering flexibility in consumption.
Benefits
Luteolin exhibits anti-inflammatory and antioxidant effects, potentially benefiting conditions involving pain and inflammation. However, quantified outcomes from human studies are limited. Animal studies suggest anti-cancer, anti-diabetic, and cardioprotective effects, but these require confirmation in human trials. Some evidence hints at benefits for individuals with diabetes and cardiovascular conditions, though more human studies are necessary. The clinical significance of luteolin's effects in humans remains uncertain due to the scarcity of large-scale RCTs. The time course for observing benefits is not well-documented and may vary depending on the condition being treated. Overall, while promising, more robust human research is needed to substantiate these benefits.
How it works
Luteolin operates through multiple biological pathways, including anti-apoptosis, anti-oxidation, and anti-inflammation, contributing to its cardioprotective effects. It interacts with body systems such as the cardiovascular and nervous systems by modulating inflammatory responses and oxidative stress. Luteolin targets various molecular pathways involved in inflammation and cell survival. The bioavailability of luteolin can vary based on the method of administration and individual factors, but specific data on absorption rates are limited. Its multifaceted mechanism of action underscores its potential as a therapeutic agent.
Side effects
Luteolin is generally considered safe, but comprehensive safety data in humans are limited. Common side effects are not well-documented due to the lack of large-scale human studies. Potential gastrointestinal side effects are uncommon but not extensively studied. Specific rare side effects are also not well-documented. Luteolin may interact with medications metabolized by similar pathways, but specific interactions are not well-studied. Caution is advised for pregnant or breastfeeding women due to limited data. There is also limited data on use in children or individuals with severe health conditions. Due to the limited safety data, it is important to consult with a healthcare provider before using luteolin, especially if you have underlying health conditions or are taking medications.
Dosage
The minimum effective dose of luteolin is not well-established for specific health benefits. Typical dosage ranges from 10 to 100 mg per day, but optimal dosing for specific effects is unclear. The maximum safe dose is not clearly defined, but high doses may increase the risk of side effects. There are no specific timing recommendations available. Luteolin is available in various forms, including capsules and extracts, but form-specific efficacy is not well-studied. Bioavailability may be influenced by the presence of other nutrients or compounds. No specific cofactors are required. Due to the lack of definitive dosage guidelines, it is best to start with a low dose and gradually increase it while monitoring for any adverse effects.
FAQs
Is luteolin safe to use?
Luteolin is generally considered safe, but comprehensive safety data are limited. Consult healthcare providers due to potential interactions with medications and exercise caution in certain populations.
When is the best time to take luteolin?
No specific timing recommendations are available for luteolin supplementation. It can be taken with or without food, depending on individual tolerance and preference.
What benefits can I expect from taking luteolin?
Benefits may vary based on the condition being treated. More research is needed to confirm efficacy in humans. Luteolin is not a cure-all and should be used under the guidance of a healthcare provider.
Can luteolin interact with other medications?
Luteolin may interact with medications metabolized by similar pathways. Consult with a healthcare provider to discuss potential interactions before starting supplementation.
Research Sources
- https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.685998/full – This meta-analysis of 18 animal studies (415 animals) found that luteolin has cardioprotective effects by reducing ischemia and improving hemodynamics in animal models. The studies were deemed high-quality with a low risk of bias, but the findings are limited by the use of animal models and potential overestimation of efficacy due to the inclusion of positive studies.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11700251/ – This review article discusses the extraction and biological activities of luteolin. It highlights luteolin's range of biological activities, including anti-inflammatory, antioxidant, and anti-cancer effects. The review provides a comprehensive overview of existing literature but focuses more on extraction methods and biological activities rather than clinical efficacy.
- https://www.frontiersin.org/journals/pain-research/articles/10.3389/fpain.2023.1114428/full – This review suggests that luteolin has potential benefits in managing pain due to its analgesic and anti-inflammatory properties. The review is primarily based on animal studies and provides insights into potential therapeutic applications of luteolin for pain management.
- https://www.mdpi.com/2227-9059/11/8/2189 – This review discusses the potential therapeutic applications of luteolin. It highlights luteolin's range of biological activities, including anti-inflammatory, antioxidant, and anti-cancer effects. The review provides a comprehensive overview of existing literature but focuses more on extraction methods and biological activities rather than clinical efficacy.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11333740/ – This review discusses the potential therapeutic applications of luteolin. It highlights luteolin's range of biological activities, including anti-inflammatory, antioxidant, and anti-cancer effects. The review provides a comprehensive overview of existing literature but focuses more on extraction methods and biological activities rather than clinical efficacy.
