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Maca Glycerite Liquid Extract

Also known as: Maca, Peruvian ginseng, Lepidium meyenii

Overview

Maca (Lepidium meyenii) is a cruciferous root vegetable native to the high Andes of Peru. Traditionally consumed for its nutritional and medicinal properties, it is now available in various forms, including glycerite liquid extracts. These extracts are prepared by using glycerin as a solvent to preserve the bioactive compounds found in the maca root. Maca is primarily used to enhance physical performance, stamina, and sexual health, and is increasingly studied for its antioxidant and adaptogenic effects. Key characteristics include its richness in macamides and glucosinolates, compounds believed to mediate its biological effects. Research on maca is moderately mature, with multiple randomized controlled trials (RCTs) and systematic reviews/meta-analyses supporting its benefits, particularly in physical performance and antioxidant activity. While data specific to glycerite liquid extracts are somewhat limited compared to powdered or capsule forms, the extraction process is thought to preserve the beneficial compounds.

Benefits

Maca supplementation has demonstrated several evidence-based benefits. A 2024 systematic review and meta-analysis showed a large effect size on physical performance metrics, such as forced swimming test, grip strength, and rota-rod test, along with significant reductions in blood lactic acid levels, indicating improved endurance and reduced fatigue. Another systematic review and meta-analysis indicated that maca supplementation improves cellular oxidative stress markers, supporting its role as an antioxidant. Potential adaptogenic effects, which may improve stress resilience and hormonal balance, have also been observed, though these are less robustly quantified. Athletes and individuals seeking enhanced physical endurance may benefit the most. Benefits are typically observed with supplementation periods ranging from weeks to months.

How it works

Maca's mechanism of action involves several biological pathways. Macamides and glucosinolates, key compounds in maca, are believed to modulate energy metabolism, antioxidant defenses, and possibly neuroendocrine functions. Maca enhances muscular endurance, reduces oxidative stress, and may influence hormonal axes. While the exact molecular targets are not fully elucidated, it is suggested that macamides may interact with endocannabinoid system receptors and antioxidant pathways. Glycerite extracts are thought to preserve polar bioactives, and glycerin as a solvent may enhance stability and absorption compared to dry powders, although direct comparative pharmacokinetic data are lacking.

Side effects

Maca is generally well-tolerated with a good safety profile in clinical studies. Common side effects are rare, with mild gastrointestinal discomfort reported in some cases. No significant adverse effects have been reported in systematic reviews. Drug interactions are not well-documented, but caution is advised for individuals with hormone-sensitive conditions due to possible endocrine effects. Contraindications include pregnancy and lactation, as safety has not been well-established. Caution is also advised in hormone-sensitive cancers. Limited data are available for special populations, and it is generally avoided in children and pregnant women unless supervised by a healthcare professional.

Dosage

While studies often use 1.5 to 3 grams of maca powder daily, the dosage for maca glycerite extract is not standardized but is typically adjusted to reflect equivalent maca root content. Higher doses have been correlated with greater physical performance benefits. Traditional use and clinical trials suggest that doses up to 3 grams daily are generally safe. Daily dosing for several weeks to months is recommended for sustained effects. Glycerite liquid extracts may offer better bioavailability, but standardized extracts with quantified macamides and glucosinolates are preferred. The glycerin solvent may aid absorption, and co-administration with meals may enhance uptake. The maximum safe dose is not well-defined, so it is important to adhere to recommended dosages.

FAQs

Is Maca glycerite extract as effective as powder?

Direct comparative studies are lacking. Glycerite extracts may preserve bioactives better but require standardization to ensure consistent potency and efficacy compared to maca powder.

How soon can benefits be expected?

Physical performance improvements are typically observed after several weeks of consistent use. Individual responses may vary, and it's important to maintain consistent dosing.

Is it safe long-term?

Current evidence supports safety for months of use. However, long-term data are limited, and it's advisable to consult with a healthcare provider for extended use.

Can it interact with medications?

No major interactions are known, but caution is advised with hormone-sensitive conditions. Consult with a healthcare provider if you are taking medications or have underlying health conditions.

Does it affect hormone levels?

Some evidence suggests mild modulation, but the clinical significance is unclear. Individuals with hormone-related conditions should use maca with caution and under medical supervision.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/39796542/ – This systematic review and meta-analysis of 21 studies (16 meta-analyzed) examined the effects of maca on physical performance. The study found large effect sizes on physical performance tests and lactic acid reduction, indicating improved endurance and reduced fatigue, with a dose-response relationship observed. The review highlights the potential of maca as a performance-enhancing supplement.
https://www.mdpi.com/2076-3921/13/9/1046 – This systematic review and meta-analysis investigated the antioxidant effects of maca supplementation. The study found significant improvements in oxidative stress markers, supporting maca's role as an antioxidant. The findings suggest that maca may help protect against cellular damage caused by oxidative stress.
https://www.mdpi.com/2072-6643/17/1/107 – This analytical chemistry study developed improved methods for the direct analysis of maca glucosinolates. The research enhances quality control for maca supplements by providing more accurate and reliable methods for quantifying key bioactive compounds. This supports standardization and quality assurance of maca products, including glycerite extracts.
https://www.arthritis.org/health-wellness/treatment/complementary-therapies/supplements-and-vitamins/supplement-and-herb-guide-for-arthritis-symptoms – This resource from the Arthritis Foundation provides general information about maca and its potential benefits for arthritis symptoms. It serves as a basic overview of maca's traditional uses and potential health benefits, though it does not provide in-depth scientific analysis.
https://pubmed.ncbi.nlm.nih.gov/33862504/ – This study focuses on the analytical quality control of maca, specifically developing methods for analyzing glucosinolates. It contributes to the standardization and quality assurance of maca products, ensuring that supplements contain consistent levels of bioactive compounds. This is crucial for achieving reliable and predictable clinical outcomes.