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Citrus Reticulata Extract

Also known as: mandarin orange extract, Citrus reticulata extract

Overview

*Citrus reticulata* extract is derived from the mandarin orange, a small citrus fruit known for its rich flavonoid content and antioxidant properties. This extract is primarily used for its potential health benefits, especially in supporting cardiovascular health and aiding weight management. The extract's flavonoids may help manage dyslipidemia, which is characterized by abnormal lipid levels in the blood. Despite some studies indicating positive effects, evidence remains mixed, necessitating further research to validate these findings. The extract is available in forms such as capsules and powders, with no standardized dosage guidelines currently available.

Benefits

Evidence suggests that *Citrus reticulata* extract may assist in weight reduction and improving lipid profiles, such as lowering total cholesterol, LDL, and triglycerides, while potentially increasing HDL levels. Some studies indicate reductions in waist circumference and improvements in insulin sensitivity, particularly for individuals with dyslipidemia or those aiming for weight loss. However, the variability in effect sizes and clinical significance across studies complicates definitive conclusions. In a randomized controlled trial (RCT) of 20 participants, significant decreases in body weight and waist circumference were observed over eight weeks, though other lipid parameters did not significantly improve. Overall, while promising, more targeted research is required to establish conclusive benefits.

How it works

The bioactive flavonoids in *Citrus reticulata* extract are thought to influence lipid metabolism by acting on specific biochemical pathways related to lipogenesis and beta-oxidation. These compounds may interact with the cardiovascular system by enhancing lipid profiles, aiding in fat metabolism, and possibly improving insulin sensitivity. Absorption of these flavonoids is generally favorable when consumed as part of a balanced diet, although their bioavailability may vary based on diet composition and individual physiology.

Side effects

Generally, *Citrus reticulata* extract is considered safe when consumed in moderation; however, comprehensive data on long-term use and high doses is limited. Side effects are not well documented but may include mild gastrointestinal discomfort in sensitive individuals. While no specific drug interactions have been extensively studied, caution is advised for those on medications that impact blood lipid levels or blood pressure. Individuals with citrus allergies should avoid this extract altogether, and special populations, such as pregnant or breastfeeding women, should consult healthcare professionals prior to use due to potential risks.

Dosage

Recommended dosages for citrus extracts generally range from 0.5 to 1 gram per day; however, specific guidelines for *Citrus reticulata* extract have not been well established. There are no specific timing recommendations, but consistent daily intake is encouraged for potential benefits. Factors such as food composition, specifically fat content in meals, may influence the absorption of flavonoids from the extract. Due to limited evidence, maximum safe doses remain undetermined, highlighting the need for further research.

FAQs

Is *Citrus reticulata* extract safe to use?

Generally considered safe when taken in moderate amounts, long-term effects and interactions with medications warrant caution.

What dosage should I take for weight loss?

Doses between 0.5 to 1 gram per day are commonly used, but specific guidance for *Citrus reticulata* extract is lacking.

Can I take this if I'm on medication?

Consult your healthcare provider before use, especially if you have medications that influence blood lipids.

Will I see immediate results?

Effects can vary; some studies show benefits in weight loss and lipid profiles, but results are not universally consistent.

Is it a substitute for a balanced diet?

No, *Citrus reticulata* extract should complement, not substitute, a healthy lifestyle and medical treatments.

Research Sources

https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.822678/full – This randomized controlled trial demonstrated that *Citrus reticulata* extract significantly reduced body weight and waist circumference in healthy individuals over an eight-week period, highlighting the extract's potential for weight management, although lipid profile changes were not significant.
https://academic.oup.com/nutritionreviews/article/82/9/1292/7272715?login=false – A systematic review discussing the effects of various citrus extracts, including *Citrus reticulata*, found potential lipid-lowering benefits upon reviewing multiple studies, though it noted high variability in evidence quality and outcomes across studies.