Mandukparnee
Also known as: Mandukaparni, Gotu Kola, Asiatic Pennywort, Centella asiatica
Overview
*Centella asiatica*, commonly known as Mandukaparni, is a perennial herbaceous creeper native to Asian countries, widely utilized in Ayurvedic medicine for its therapeutic properties. It possesses bioactive compounds like pentacyclic triterpenes (asiaticoside, madecassoside, asiatic acid), which contribute to its diverse applications, including cognitive enhancement, anti-anxiety effects, wound healing, anti-inflammatory action, and antioxidant benefits. Research into its efficacy shows moderate maturity, with numerous clinical trials and systematic reviews demonstrating its benefits, particularly in cognitive function and wound healing, although further high-quality studies are warranted to validate these effects comprehensively.
Benefits
The primary benefits of *Centella asiatica* include improved cognitive function and mood, as evidenced by a systematic review reporting increased alertness (SMD: 0.71) and reduced anger (SMD: -0.81). The herb also enhances wound healing by promoting angiogenesis and reducing inflammatory markers, critical for recovery. Secondary benefits include its anxiolytic properties, blood pressure management, and diabetes control, although outcomes can vary. The findings indicate moderate yet significant efficacy, particularly for mood enhancement and wound healing, with clinically observable effects after hours to weeks of treatment depending on the application.
How it works
Mandukaparni operates through multiple biological pathways, enhancing neurotransmitter functionality and showcasing anti-inflammatory and antioxidant effects. Its active compounds interact with the nervous system to balance neurotransmitters and hormones, while in the cardiovascular realm, it positively influences nitric oxide synthase activity to reduce blood clotting. Pentacyclic triterpenes target inflammatory pathways (e.g., IL-1β, TNFα) and promote angiogenesis (e.g., VEGF). Overall, it functions to support cognitive health and accelerate healing processes.
Side effects
While *Centella asiatica* is generally considered safe, potential side effects include gastrointestinal disturbances, with reports suggesting a lesser frequency of increased blood glucose and lipid levels, particularly in susceptible individuals. Rare side effects are poorly documented, but caution is advised regarding interactions with diabetes and cardiovascular medications. Patients with underlying conditions such as liver disease or heart disease should seek medical guidance before use, and it is recommended to avoid this herb during breastfeeding due to insufficient safety data. Understanding these risk factors is crucial for safe application.
Dosage
Recommended dosages of *Centella asiatica* typically range from 1 to 3 grams of powdered form or 1 capsule twice daily. The exact dosing may vary according to the specific formulation and therapeutic goals. Though a maximum safe dose is not definitively established, higher intakes should be approached cautiously and monitored by healthcare professionals. It is generally advisable to consume it in divided doses throughout the day, particularly synchronizing with conditions being treated. Furthermore, bioavailability can be improved through mechanisms like nanoencapsulation, enhancing overall efficacy.
FAQs
Is *Centella asiatica* safe for everyone?
While generally safe, those with diabetes, heart, or liver conditions should consult a physician before use.
How frequently should I take *Centella asiatica*?
It is usually taken twice daily, with variations depending on individual health goals.
When can I expect results after taking it?
Cognitive and mood enhancements may occur within hours to days, while wound healing effects take several weeks.
Is *Centella asiatica* the same as Brahmi?
No, while both herbs are known for cognitive enhancement, they have distinct properties and uses.
Research Sources
- https://www.pulsus.com/scholarly-articles/nutrifood-chemistry-2018-systematic-review-and-metaanalysis-of-centella-asiatica-l-urb-on-mood-and-cognitive-function-pa.pdf – This systematic review and meta-analysis included 11 trials with 642 patients, demonstrating that *Centella asiatica* enhances alertness and decreases anger ratings, although no significant effects were found on other cognitive domains. The study highlights the effect size and implications for cognitive health.
- https://pubmed.ncbi.nlm.nih.gov/35328954/ – The review presents findings on *C. asiatica* regarding wound healing, indicating substantial benefits in enhancing angiogenesis and granulation while reducing inflammation. It underscores the need for more clinical trials for comprehensive validation.
- https://www.1mg.com/ayurveda/mandukaparni-222 – This source summarizes the various benefits of Mandukaparni, including anxiety reduction and blood clot prevention, while also noting potential interactions with medications for diabetes and liver diseases, emphasizing the importance of cautious use.
