Mangifera Indica Fruit Extract
Also known as: Mangifera indica, Mango, Mango fruit extract, Stadice®, Mangifera indica L.
Overview
Mangifera indica fruit extract is derived from the tropical mango fruit, known for its rich content of vitamins, polyphenols, and bioactive compounds like mangiferin. It is utilized as a dietary supplement due to its antioxidant, anti-inflammatory, metabolic, cognitive, and antimicrobial properties. The extract typically includes components from both the fruit flesh and peel, providing fiber, vitamins A, C, E, B-complex, carotenoids, and various polyphenols. While research is ongoing, there is a growing body of evidence from human clinical trials and systematic reviews supporting its health benefits, though many studies are still preclinical or small-scale. The quality of evidence varies, with recent systematic reviews applying rigorous criteria to focus on randomized controlled trials in human subjects.
Benefits
Mangifera indica fruit extract offers several evidence-based health benefits. A recent randomized controlled trial (RCT) demonstrated significant improvements in mental speed, attention, working memory, response inhibition, and verbal learning in healthy adults engaged in e-sports (n≥30, p<0.05) with a proprietary extract (Stadice®), indicating cognitive enhancement. Systematic review evidence suggests that *M. indica* by-products and mangiferin can positively impact cardiometabolic health by improving cardiovascular risk factors, obesity, diabetes, and metabolic syndrome through antioxidant and anti-inflammatory mechanisms. Clinical evidence also supports the use of mango extract mouthwash for reducing cariogenic bacteria, thereby potentially lowering the risk of dental caries. Furthermore, animal studies and some human data point to antidiabetic effects, including reductions in blood glucose and glycated hemoglobin. The extract exhibits strong antioxidant and anti-inflammatory activities, contributing to reduced oxidative stress and inflammation, which are implicated in numerous chronic diseases. Preclinical studies have also reported antimicrobial, antifungal, and potential anticancer effects.
How it works
The primary mechanism of action for Mangifera indica fruit extract is attributed to mangiferin, a potent bioactive compound. Mangiferin functions as a powerful antioxidant by scavenging free radicals and exerts anti-inflammatory effects by modulating key signaling pathways such as NF-κB and PI3K/AKT. These pathways are crucial regulators of inflammation, apoptosis, and cell proliferation. Beyond mangiferin, other polyphenols and vitamins present in mango extracts contribute to overall health by supporting vascular function, nervous system health, and immune system integrity. The absorption and bioavailability of these compounds can vary depending on the extract formulation, with patented technologies (e.g., insolib) designed to enhance their stability and uptake in the body.
Side effects
Mangifera indica fruit extract is generally well-tolerated and possesses a good safety profile, as observed in human studies. No serious adverse events have been reported in randomized controlled trials involving healthy adults. Common side effects are rare and not extensively documented, but sensitive individuals might experience mild gastrointestinal discomfort. Currently, there are no significant drug interactions or contraindications reported in the scientific literature. However, specific safety conclusions for special populations, such as pregnant women and children, cannot be firmly established due to a lack of sufficient research data. It is always advisable to consult a healthcare professional before starting any new supplement, especially if you have pre-existing health conditions or are taking other medications.
Dosage
Optimal dosing ranges for Mangifera indica fruit extract are not yet firmly established due to variability in extract composition and study designs. Clinical trials have utilized standardized extracts; for instance, a proprietary extract (Stadice®) demonstrated efficacy in cognitive domains, though specific dosage details were not explicitly provided in the available research. The timing and formulation (e.g., oral capsules for cognitive support versus mouthwash for dental health) depend on the intended therapeutic use. Absorption of active compounds may be enhanced by specific formulations designed to minimize degradation. It is crucial to follow product-specific recommendations or consult with a healthcare professional to determine an appropriate dosage, especially given the lack of firmly established upper limits or safety thresholds for all formulations.
FAQs
Is mango fruit extract safe for daily use?
Current evidence from human studies indicates that mango fruit extract is generally safe for daily use in adults at the dosages studied, with a good safety profile and rare side effects.
How soon can benefits be expected?
Cognitive improvements have been observed within weeks in some randomized controlled trials, while dental benefits from mouthwash use may be seen with consistent, regular application.
Does it interact with medications?
No significant drug interactions have been documented, but caution is advised. It is recommended to consult a healthcare professional if you are taking other medications.
Is whole mango fruit equivalent to the extract?
Extracts are concentrated sources of bioactive compounds, such as mangiferin, and may offer more potent effects compared to consuming whole mango fruit alone.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10744517/ – This systematic review of randomized controlled trials indicates that Mangifera indica by-products and mangiferin exhibit beneficial effects on cardiometabolic risk factors, obesity, diabetes, and metabolic syndrome through antioxidant and anti-inflammatory mechanisms. The review followed rigorous PRISMA and Cochrane guidelines, highlighting moderate to high quality evidence despite some heterogeneity in included studies.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11361472/ – This randomized controlled trial involving healthy adults (e-sports players) demonstrated that a proprietary Mangifera indica extract (Stadice®) significantly improved cognitive functions, including mental speed, attention, working memory, and verbal learning, with a good safety profile. While the methodology was sound, the study was manufacturer-funded, which could introduce potential bias.
- https://journals.sagepub.com/doi/10.1177/11786388231204200 – This clinical trial provides evidence that mango extract mouthwash is effective in reducing cariogenic bacteria, suggesting its potential role in lowering the risk of dental caries. Although peer-reviewed, specific details regarding sample size and duration were not fully elaborated, leading to a moderate quality assessment.
- https://onlinelibrary.wiley.com/doi/10.1155/2017/6949835 – This comprehensive review summarizes the diverse pharmacological activities of various mango parts, including antioxidant, antidiabetic, and potential anticancer effects. While valuable, the review largely incorporates preclinical data, emphasizing the need for more human randomized controlled trials to confirm these findings in clinical settings.
