Calendula Peach
Also known as: Calendula officinalis, Calendula, pot marigold, marigold flower extract
Overview
Calendula officinalis, commonly known as calendula or pot marigold, is a flowering plant widely recognized for its medicinal properties. Extracts from the flower heads are traditionally used for wound healing, anti-inflammatory, and antiseptic purposes. It is available in various forms, including creams, gels, ointments for topical application, and sometimes oral formulations. The plant's bioactive compounds, such as flavonoids, triterpenoids, and carotenoids, contribute to its therapeutic effects. Research suggests that calendula possesses anti-inflammatory, antimicrobial, and wound-healing properties, making it a popular choice for skin-related applications. While numerous clinical trials and animal studies exist, the evidence quality varies, with some systematic reviews highlighting positive effects but also noting inconsistencies and the need for more rigorous, large-scale randomized controlled trials to confirm its benefits.
Benefits
Calendula officinalis demonstrates several evidence-based benefits, primarily in wound healing. A systematic review indicated faster resolution of inflammation and increased granulation tissue formation in acute wounds treated with calendula extract. Clinical studies have also shown a reduction in ulcer surface area in venous ulcers. However, results are mixed for chronic wounds like diabetic leg ulcers and burns, with some studies showing no significant benefit compared to controls. There is potential for calendula to prevent or reduce the severity of acute radiation dermatitis in cancer patients, although trial results are conflicting. Patients with venous ulcers and acute wounds may experience the most significant benefits. Effect sizes in human trials have been modest and inconsistent, necessitating further research to validate these findings.
How it works
Calendula's mechanism of action involves its bioactive compounds, including flavonoids, triterpenoids, and carotenoids, which exert anti-inflammatory effects by modulating inflammatory cytokines and oxidative stress pathways. It promotes granulation tissue formation and angiogenesis, facilitating tissue repair. Additionally, its antimicrobial properties help reduce the risk of infection in wounds. Topical application allows for localized absorption, while systemic bioavailability is less studied but likely limited. These combined effects contribute to calendula's wound-healing and anti-inflammatory properties, making it a valuable herbal remedy for various skin conditions and injuries.
Side effects
Calendula officinalis is generally considered safe when used topically, with few adverse effects reported in clinical trials. The most common side effects include mild skin irritation or allergic contact dermatitis, occurring in less than 5% of users. Rare side effects may include hypersensitivity reactions in sensitive individuals. No significant drug interactions have been reported. Contraindications include known allergy to Calendula or related plants in the Asteraceae family. Limited data are available for pregnant or breastfeeding women, so caution is advised in these populations. Overall, calendula has a favorable safety profile for topical use, but users should be aware of potential allergic reactions and exercise caution in specific populations.
Dosage
Typical topical formulations of Calendula officinalis range from 1% to 10% calendula extract in creams or gels. There is no standardized dosing established due to variability in formulations and study protocols. Application frequency in studies has ranged from once to multiple times daily. Oral dosing is less common and not well standardized. The formulation base can enhance absorption, with ointments potentially increasing skin retention. Due to the lack of standardized dosing, it is important to follow product-specific instructions and consult with a healthcare professional for appropriate usage. While generally safe, exceeding recommended application frequency or concentration may increase the risk of skin irritation.
FAQs
Is calendula effective for all wound types?
Evidence supports its benefit mainly in acute wounds and venous ulcers. Efficacy in diabetic ulcers and burns is unclear.
Can it be used preventively for radiation dermatitis?
Mixed results; some trials show benefit, others do not. More research is needed.
Is it safe for long-term use?
Generally safe topically; long-term safety data is limited. Monitor for any adverse reactions.
How soon can results be expected?
Improvements in inflammation and healing markers may appear within days to weeks with consistent use.
Are there any drug interactions?
None well documented, but it's always best to consult with a healthcare provider if you are taking other medications.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/31145533/ – A systematic review of 14 studies (7 animal and 7 clinical trials) evaluated Calendula officinalis extract for wound healing. The review found moderate evidence for improved inflammation resolution and granulation tissue in acute wounds, but mixed results in chronic wounds and burns. The authors highlighted the need for larger, well-designed RCTs to confirm these findings.
- https://onlinelibrary.wiley.com/doi/abs/10.1111/wrr.12737 – This systematic review examined the effectiveness of Calendula officinalis for wound healing. The review included multiple studies and found that calendula may promote faster healing and reduce inflammation in acute wounds. However, the authors noted that the quality of evidence was variable, and more rigorous studies are needed to confirm these benefits.
- https://www.webmd.com/vitamins/ai/ingredientmono-235/calendula – WebMD provides general information on Calendula, noting its traditional use for wound healing and skin conditions. It highlights the plant's potential anti-inflammatory and antimicrobial properties. The resource also mentions common uses and precautions associated with calendula.
- https://medlineplus.gov/druginfo/natural/235.html – MedlinePlus offers information on Calendula, including its uses, potential side effects, and interactions. It notes that calendula is often used topically for skin inflammation and wound healing. The resource advises caution and consultation with a healthcare provider before using calendula, especially for pregnant or breastfeeding women.
- https://ijaers.com/detail/pharmacological-activity-of-calendula-officinalis-a-systematic-review/ – This systematic review confirms the anti-inflammatory, antiseptic, and wound healing effects of Calendula officinalis, attributing these properties to its bioactive compounds. The review emphasizes the therapeutic potential of calendula but also notes variability in study designs and quality, suggesting a need for more standardized research approaches.