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Mena Q7

Also known as: Menaquinone-7, MK-7, Vitamin K2, MenaQ7

Overview

Menaquinone-7 (MK-7), commonly known as Vitamin K2, is a fat-soluble vitamin and a specific form of vitamin K2 used as a dietary supplement. MenaQ7 is a commercial brand of MK-7, produced through bacterial fermentation. It is primarily utilized for its significant role in supporting cardiovascular and bone health. MK-7 is naturally found in fermented foods like natto. MenaQ7 is recognized for its high purity and all-trans configuration, which is the biologically active form, ensuring optimal efficacy. Research on MK-7 is ongoing, with several clinical trials demonstrating its benefits, particularly in improving arterial stiffness and bone density. While the research maturity is moderate, the quality of available evidence, including well-designed randomized controlled trials, is generally good, though more diverse population studies are still needed.

Benefits

Menaquinone-7 (MK-7) offers several evidence-based benefits, primarily for cardiovascular and bone health. For cardiovascular health, MK-7 supplementation has been shown to significantly reduce arterial stiffness and decrease levels of dp-ucMGP (dephosphorylated uncarboxylated matrix Gla protein), a key marker of vitamin K status. A notable three-year study in postmenopausal women demonstrated a 50% reduction in dp-ucMGP levels with 180 µg/day of MK-7, indicating improved arterial elasticity. This effect size is substantial, highlighting improved vitamin K status. For bone health, MK-7 may improve bone strength and density, particularly beneficial for postmenopausal women. There is also supporting evidence for its potential in reducing vascular calcification, although more research is needed to confirm this secondary effect. The benefits are typically observed within several months of consistent supplementation. Postmenopausal women appear to be a population that benefits significantly from MK-7 supplementation, showing improvements in both cardiovascular and bone health markers.

How it works

Menaquinone-7 (MK-7) primarily functions by activating specific vitamin K-dependent proteins crucial for bone and vascular health. Its main mechanism involves carboxylating proteins such as osteocalcin and matrix Gla protein (MGP). Activated osteocalcin is essential for binding calcium to the bone matrix, promoting bone mineralization and strength. Activated MGP, on the other hand, plays a critical role in inhibiting calcium deposition in soft tissues, particularly in arteries, thereby preventing vascular calcification. By activating these proteins, MK-7 effectively promotes calcium utilization in bones while preventing its harmful accumulation in arteries. MK-7 is well-absorbed and remains bioavailable in the bloodstream for an extended period, up to 48 hours, allowing for sustained activation of these vital proteins.

Side effects

Menaquinone-7 (MK-7) is generally considered safe with a low incidence of side effects. Common side effects (greater than 5%) are not typically reported. Uncommon side effects (1-5%) may include mild gastrointestinal disturbances. Rare side effects (less than 1%) are infrequent, though a case study reported hypotension, which might be linked to drug interactions. A critical safety consideration is its potential interaction with anticoagulant medications, such as warfarin, which work by interfering with vitamin K's clotting functions. Individuals on anticoagulant therapy should strictly consult a healthcare provider before taking MK-7, as it could reduce the effectiveness of these medications and increase the risk of blood clots. Contraindications include individuals currently on anticoagulant therapy. Special populations, such as pregnant or breastfeeding women, should also seek medical advice from a healthcare provider before initiating MK-7 supplementation to ensure safety for both mother and child. Overall, while generally safe, awareness of potential drug interactions and specific contraindications is crucial.

Dosage

The minimum effective dose for Menaquinone-7 (MK-7) is generally considered to be 180 µg/day. Optimal dosage ranges typically fall between 180-360 µg/day. While a maximum safe dose has not been definitively established, doses up to 360 µg/day are widely considered safe and well-tolerated in most individuals. There are no specific timing recommendations for MK-7; it can be taken at any time of day, preferably with meals. Absorption of MK-7 is enhanced when consumed with dietary fats, as it is a fat-soluble vitamin. Therefore, taking it with a meal containing some fat is advisable for optimal absorption. When selecting a supplement, fermented forms like MenaQ7 are often preferred due to their high purity and demonstrated efficacy. There are no specific required cofactors identified that are necessary for its absorption or function.

FAQs

What is the best form of Vitamin K2 to take?

The all-trans form of Menaquinone-7 (MK-7) is considered the most biologically active and effective. Commercial products like MenaQ7 are specifically noted for their purity and all-trans configuration, ensuring optimal efficacy.

Can I take Menaquinone-7 if I am on blood thinners?

If you are on anticoagulant therapy, such as warfarin, you must consult your healthcare provider before taking Menaquinone-7. Vitamin K can interfere with these medications, potentially reducing their effectiveness.

When is the best time to take Menaquinone-7?

There are no specific timing recommendations for Menaquinone-7. It can be taken at any time of day, but it is best absorbed when taken with a meal that contains some fat, as it is a fat-soluble vitamin.

How long does it take to see benefits from Menaquinone-7?

Improvements in cardiovascular and bone health markers are typically observed within several months of consistent Menaquinone-7 supplementation. Individual results may vary based on dosage and baseline health status.

Is all Vitamin K2 the same?

No, not all Vitamin K2 supplements are equally effective. Menaquinone-7 (MK-7) is a specific form known for its longer half-life and superior bioavailability compared to other forms like MK-4. Purity and the all-trans configuration are also important factors.

Research Sources

https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Vitamin-K2.pdf – This source provides an overview of Vitamin K2, including its various forms and potential health benefits. It highlights the role of MK-7 in bone and cardiovascular health, emphasizing its importance for cognitive vitality and overall health.
https://info.davincilabs.com/menaq7-guide – This guide focuses on MenaQ7, a specific brand of MK-7, detailing its production, purity, and efficacy. It outlines the benefits of MenaQ7 for bone and cardiovascular health, supported by clinical research.
https://menaq7.com/news/menaq7-1-year-cardio-study-benefits-in-men-woman/ – This source discusses a one-year study on MenaQ7's cardiovascular benefits in both men and women. It highlights how MK-7 supplementation improved vascular health, particularly in individuals with poor vitamin K status, demonstrating its broad applicability.
https://pubmed.ncbi.nlm.nih.gov/23062766/ – This PubMed entry refers to a study investigating the effects of MK-7 supplementation on dp-ucMGP levels. The research found that MK-7 dose-dependently decreased dp-ucMGP, indicating improved vitamin K status and potential benefits for arterial health.
https://menaq7.com/news/study-says-menaq7-pure-k2-shown-to-protect-against-calcification/ – This source reports on a study indicating that MenaQ7, a pure form of K2, helps protect against calcification. It underscores the role of MK-7 in preventing arterial stiffness and promoting cardiovascular health by inhibiting calcium deposition in soft tissues.