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Mesua

Also known as: Mesua nagassarium, Mesua speciosa, Ironwood, Cobra's Saffron, Nagakesara, Mesua ferrea

Overview

Mesua ferrea, also known as Ironwood or Cobra's Saffron, is a tree native to Southeast Asia. Various parts of the tree, including the flowers, seeds, and bark, have been used in traditional medicine. It contains compounds like xanthones, flavonoids, and phenolic acids, which are believed to contribute to its medicinal properties. Traditionally, Mesua ferrea has been used for its potential anti-inflammatory, antimicrobial, and antioxidant effects. However, it's important to note that scientific research, particularly in the form of systematic reviews and meta-analyses, is limited. Most studies are small-scale or in vitro, and robust clinical trials are lacking. Therefore, while it has a history of traditional use, its efficacy and safety as a supplement require further investigation.

Benefits

The potential benefits of Mesua ferrea are primarily based on traditional use and limited scientific studies. It is suggested to have anti-inflammatory and antioxidant effects, although human studies are scarce. Some in vitro studies indicate potential antimicrobial properties. However, due to the lack of robust clinical trials, the effect sizes and clinical significance of these potential benefits are not well-established. There are no specific population benefits that have been well-documented. More research is needed to confirm these benefits and determine the appropriate use of Mesua ferrea as a supplement.

How it works

The mechanism of action of Mesua ferrea is not well-defined due to limited research. It is suggested that it may interact with inflammatory pathways and antioxidant defense mechanisms. It could potentially affect the immune and cardiovascular systems, but the evidence supporting these interactions is limited. The specific molecular targets and the absorption and bioavailability of its active compounds have not been studied extensively. Further research is needed to elucidate the precise mechanisms through which Mesua ferrea may exert its effects.

Side effects

The safety profile of Mesua ferrea is not well-established due to a lack of formal safety studies. While it is generally considered safe in traditional use, common, uncommon, and rare side effects are not well-documented in available literature. Potential interactions with other medications have not been thoroughly studied. There are no formally established contraindications. However, pregnant or breastfeeding women should consult healthcare providers before use due to the lack of safety data. Caution is advised due to the limited scientific evidence regarding its safety.

Dosage

Due to the limited scientific research, there are no established dosing guidelines for Mesua ferrea. The minimum effective dose, optimal dosage ranges, and maximum safe dose have not been determined. There are no specific timing considerations or form-specific recommendations available. The absorption factors and required cofactors are also not studied. As a result, it is difficult to provide specific dosage recommendations, and consultation with a healthcare provider is advised before use.

FAQs

Is Mesua ferrea safe to use?

Safety data is lacking, so caution is advised. Consult a healthcare provider before use, especially if you are pregnant, breastfeeding, or taking other medications.

What are the expected benefits of Mesua ferrea?

Benefits are not well-documented. Limited studies suggest potential anti-inflammatory and antioxidant effects, but more research is needed.

How should Mesua ferrea be taken?

No specific guidelines are available. Consult a healthcare provider for personalized advice due to limited scientific evidence.

Can Mesua ferrea interact with other medications?

Potential interactions are not well-studied. Discuss all medications and supplements with a healthcare provider before using Mesua ferrea.

Research Sources

  • https://bjsm.bmj.com/content/52/6/376 – This article discusses the updated PRISMA guidelines for systematic reviews. It provides a checklist and explanation to improve the reporting of systematic reviews and meta-analyses, ensuring transparency and accuracy in research synthesis.
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC6686118/ – This study investigates the anti-inflammatory and analgesic effects of Mesua ferrea extracts in animal models. The results suggest that the extracts possess significant anti-inflammatory and pain-relieving properties, supporting its traditional use for these purposes.
  • https://pubmed.ncbi.nlm.nih.gov/39404918 – This study focuses on the chemical constituents of Mesua ferrea and their potential biological activities. It identifies various compounds, including xanthones and flavonoids, which may contribute to its antioxidant and antimicrobial properties.
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC9556856/ – This review examines the traditional uses, phytochemistry, and pharmacological activities of Mesua ferrea. It highlights its potential in treating various ailments, including inflammation, infections, and oxidative stress, based on both in vitro and in vivo studies.
  • https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.055654 – This is an American Heart Association presidential advisory on dietary cholesterol and cardiovascular risk. It concludes that there is no need to change the recommendations regarding dietary cholesterol intake, as current evidence does not support a significant impact on blood cholesterol levels or cardiovascular disease risk.