Micronized Purified Flavonoid Fraction
Also known as: Micronized Purified Flavonoid Fraction, MPFF, Daflon®, Micronized Diosmin, Micronized Hesperidin, Micronized Purified Flavonoid Fraction (MPFF)
Overview
Micronized Purified Flavonoid Fraction (MPFF) is a venoactive drug composed of 90% micronized diosmin and 10% flavonoids, particularly hesperidin, derived from citrus fruits. It is micronized to enhance bioavailability and is primarily indicated for chronic venous diseases (CVD), post-thrombotic syndrome (PTS), and hemorrhoidal conditions. Key characteristics of MPFF include its ability to improve venous tone, support lymphatic drainage, and reduce capillary permeability while exhibiting anti-inflammatory effects. Its clinical use is backed by extensive research, including multiple randomized controlled trials and systematic reviews demonstrating its efficacy in alleviating symptoms associated with venous disorders and improving quality of life for affected patients.
Benefits
MPFF provides several evidence-based benefits. It significantly alleviates leg symptoms in patients suffering from CVD, with reductions in leg pain (RR 0.53, P=0.0001) and heaviness (RR 0.35, P<0.00001), and enhances overall quality of life. This improvement is reflected in measurable indices such as the CIVIQ-14 scale. MPFF also accelerates venous ulcer healing when used alongside standard care. Additionally, it is effective in PTS by promoting venous recanalization and decreasing venous reflux and remodeling. For patients dealing with hemorrhoidal disease, MPFF alleviates pain, bleeding, and discomfort. These benefits are supported by strong evidence from systematic reviews indicating various positive outcomes across different populations, particularly those with chronic venous issues.
How it works
The primary mechanism of MPFF involves enhancing venous tone and lymphatic drainage while reducing capillary permeability. MPFF interacts with the venolymphatic system to improve microcirculation, thereby alleviating symptoms associated with venous insufficiency. While the precise molecular mechanisms are yet to be fully understood, studies indicate its action on inflammatory pathways and capillary integrity, contributing to its therapeutic effects in venous disorders.
Side effects
MPFF is generally well-tolerated, presenting a safety profile similar to placebo. Common side effects, occurring in more than 5% of users, include gastrointestinal disturbances and autonomic symptoms like dizziness and mild nausea. Uncommon side effects may include minor allergic reactions, while rare serious side effects have yet to be substantiated. No major drug interactions are reported, though caution is advised when combined with other medications influencing blood clotting or venous tone. MPFF is not contraindicated but should be administered under medical supervision for individuals with complex health conditions and is approached cautiously in pregnant or breastfeeding women and children.
Dosage
The typical recommended dosage for MPFF is 500 mg taken twice daily. This dosage may be adjusted based on specific clinical needs; however, no maximum safe dosage has been officially defined, with doses above 1000 mg per day being discouraged due to lack of additional benefit. MPFF can be taken with or without food, and its micronized formulation contributes to improved absorption by ensuring smaller particle size. Optimal effects are generally observed within a timeframe of 2-6 months.
FAQs
Is MPFF safe to use?
MPFF is generally safe and well-tolerated, with a side effect profile akin to placebo.
When should I take MPFF?
It is typically taken twice daily, with no specific restrictions regarding food intake.
How soon can I expect results from MPFF?
Most users notice significant improvements in symptoms and quality of life within a few weeks to months.
Can I take more than the recommended dose of MPFF?
Higher doses beyond 600 mg per day do not provide additional benefits and are not recommended.
Research Sources
- https://www.semanticscholar.org/paper/Efficacy-of-micronized-purified-flavonoid-fraction-Kakkos-Nicolaides/58f46e979bf12073615c80a732e41ca21d3375b7 – A systematic review and meta-analysis of RCTs found that MPFF significantly improves multiple leg symptoms and enhances quality of life for patients with chronic venous disease, with high-quality evidence supporting its efficacy.
- https://pubmed.ncbi.nlm.nih.gov/29385792/ – This narrative review summarizes findings from numerous studies on MPFF's effectiveness in addressing pathophysiological aspects of post-thrombotic syndrome, highlighting its benefits for venous recanalization and reduced venous reflux.
- https://onlinelibrary.wiley.com/doi/full/10.1002/rth2.12527 – A systematic review focusing on hemorrhoidal disease demonstrating that MPFF significantly reduces symptoms including bleeding, pain, and discomfort in patients suffering from this condition.
- https://pubmed.ncbi.nlm.nih.gov/12487623/ – This clinical trial emphasizes MPFF's safety and efficacy in treating chronic venous insufficiency, with reported improvements in leg-related symptoms.
- https://pubmed.ncbi.nlm.nih.gov/32399811/ – An overview of studies exploring the role of flavonoid supplementation in venous health, underscoring the significance of MPFF as a potent intervention.
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