Miliacin
Also known as: Miliacin, 1,2-dipalmitoyl-3-O-(β-D-glucopyranosyl)-sn-glycerol, Miliacin ester, Miliacin polar lipid complex, MePL
Overview
Miliacin is a bioactive lipid derived from plants, notably millet, and is often formulated as a polar lipid complex (MePL) for enhanced bioavailability. It is primarily investigated for its potential to improve hair health, specifically reducing hair loss and promoting hair density. Research on miliacin is still in its early to intermediate stages, with a limited number of clinical trials. The available evidence is of moderate quality, highlighted by one randomized controlled trial (RCT) that suggests positive effects on hair health. Miliacin's encapsulation in polar lipids aims to improve its absorption and stability, making it a potentially effective supplement for individuals experiencing hair thinning. Further research is needed to fully elucidate its benefits and optimal usage.
Benefits
Miliacin, particularly when encapsulated in polar lipids (MePL), has demonstrated potential benefits for hair health. A 12-week RCT indicated that MePL supplementation significantly reduced the proportion of hair in the telogen (resting) phase and improved scalp health, leading to increased hair density. These benefits were observed in adults experiencing hair thinning or early hair loss. While the study reported statistically significant improvements (p < 0.05), specific effect sizes were not detailed in the abstract. The clinical significance is considered moderate based on the available data. Further research is needed to confirm these findings and explore the full range of benefits.
How it works
Miliacin is hypothesized to improve hair health by stimulating cell proliferation in hair follicles and modulating the hair cycle. Specifically, it aims to reduce the proportion of hair in the telogen (resting) phase, promoting hair growth. The exact molecular targets are not fully understood, but it likely involves lipid signaling pathways in hair follicle stem cells. Encapsulation in polar lipids is intended to enhance absorption and delivery of miliacin to the skin and hair follicle microenvironment, improving its overall bioavailability and effectiveness.
Side effects
The available data on miliacin's safety profile is limited, but the existing RCT reported no significant adverse events associated with its use. No common, uncommon, or rare side effects have been reported in the literature. There is currently no data available regarding potential drug interactions or contraindications. Due to the limited research, there is also a lack of data for special populations, such as pregnant or lactating women, children, or individuals with chronic diseases. Further research is needed to fully assess the safety profile of miliacin and identify any potential risks or interactions.
Dosage
Due to the limited research on miliacin, specific dosage guidelines have not been firmly established. The referenced study used a proprietary formulation (MePL) at an undisclosed dose. Therefore, minimum effective, optimal, and maximum safe doses are currently undetermined. In the referenced study, the formulation was administered daily for at least 12 weeks. It is recommended to use miliacin encapsulated in polar lipids to enhance absorption. Further research is needed to determine appropriate dosage ranges and long-term safety thresholds.
FAQs
How long does it take to see results from miliacin supplementation?
The available evidence suggests that benefits, such as improved hair density and reduced hair loss, may be observed after 12 weeks of daily supplementation.
Is miliacin safe to use?
The limited research available has not reported any significant safety concerns. However, more research is needed to fully assess its safety profile, especially for long-term use and in specific populations.
What type of hair loss does miliacin help with?
Miliacin has shown promise in reducing hair loss and improving hair density in adults with hair thinning. It is not a cure for all types of hair loss, and its efficacy may be limited to specific populations and formulations.
How should I take miliacin for best results?
Current evidence supports daily supplementation for at least 12 weeks. It is recommended to use a formulation encapsulated in polar lipids to enhance absorption and bioavailability.
Are there any known interactions with medications?
There is currently no data available regarding potential drug interactions with miliacin. Consult with a healthcare professional before starting any new supplement.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/31135099/ – This randomized controlled trial investigated the effects of miliacin encapsulated by polar lipids (MePL) on hair health. The study found that MePL supplementation significantly reduced the proportion of hair in the telogen phase and improved scalp health and hair density in adults with hair thinning. The results suggest that MePL may be a beneficial supplement for improving hair health.
- https://pubmed.ncbi.nlm.nih.gov/36449274/ – This systematic review examined the use of nutritional supplements for hair loss. While it provides general support for some nutritional interventions, miliacin was not specifically reviewed or highlighted. The review offers a broader context for understanding the potential role of supplements in managing hair loss.
- https://www.mdpi.com/2077-0383/14/6/1817 – This is an open access article in the Journal of Clinical Medicine. The article discusses various treatments for androgenetic alopecia, but does not specifically focus on Miliacin. It provides a broader context for understanding hair loss treatments.
- https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.998623/full – This systematic review and meta-analysis focuses on evaluating hair loss treatments, but does not include Miliacin. It demonstrates robust methodology for assessing hair loss interventions, providing a benchmark for future research on Miliacin.
- https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2806418 – This article discusses the efficacy of microneedling with or without topical minoxidil for androgenetic alopecia. It is not directly related to Miliacin, but provides a comparison point for other hair loss treatments and highlights the importance of rigorous study design.
