Morosil Sicilian Red Orange Fruit Extract
Also known as: Citrus sinensis (L.) Osbeck, Moro blood orange, Sicilian red orange, Blood orange extract, Morosil®
Overview
Morosil® is a standardized extract from the Moro cultivar of *Citrus sinensis*, specifically cultivated in Sicily. This extract is notable for its rich content of bioactive compounds including anthocyanins (notably cyanidin 3-glucoside), flavonoids, hydroxycinnamic acids, and ascorbic acid. It is primarily promoted for its potential in weight management and obesity prevention due to its antioxidant, anti-inflammatory, and metabolic modulating properties. Research on Morosil® has included several randomized, double-blind, placebo-controlled studies, affirming its efficacy and safety in supporting weight loss efforts, particularly among overweight individuals. Its overall research maturity is regarded as high, validated by a plethora of clinical studies demonstrating consistent results.
Benefits
Morosil® demonstrates several evidence-backed benefits, particularly in weight management. Clinical trials indicate that it can result in significant reductions in body mass, with a noted mean reduction of 4.2% in body weight compared to a 2.2% reduction in the placebo group after 6 months (p = 0.015). Additionally, significant decreases in BMI, waist, and hip circumference were observed, with clinical significance in overweight individuals. Secondary benefits may include anti-adipogenic effects that could inhibit fat storage and promote weight loss, alongside antioxidant effects that contribute to metabolic health. Overall, clinical evidence suggests its efficacy as a complementary approach for weight management, particularly in populations struggling with obesity.
How it works
Morosil® functions by modulating multiple biological pathways, primarily through its anthocyanins that influence lipid metabolism. It acts on adipose tissue and the liver, suppressing gene expression associated with fat accumulation and enhancing fat breakdown. The antioxidant properties can reduce oxidative stress while the anti-inflammatory effects may further support metabolic health, contributing to its efficacy in managing body weight and composition.
Side effects
Morosil® is generally well-tolerated, with a comprehensive safety assessment indicating no common side effects reported (>5%), and no cases of uncommon (<5%) or rare (<1%) side effects have been documented in clinical trials. Liver toxicity markers remained within normal ranges throughout studies, suggesting a favorable safety profile. While there are no known drug interactions, it is advisable for individuals on medications or with underlying health conditions to consult healthcare providers before starting supplementation. The studies primarily focused on otherwise healthy overweight adults, leaving a gap in data regarding safe usage in children, pregnant women, or those with severe medical conditions.
Dosage
The recommended dosage for Morosil® typically ranges around 400 mg per day, as evidenced in clinical studies demonstrating its effectiveness for weight management. This dosage is both minimum effective and optimal based on available evidence. While no maximum safe dosage has been established, no adverse effects were reported at this level. Timing of administration is flexible; however, consistency is advised for efficacy, and it should be integrated into a daily routine. Morosil® is commonly available in standardized forms, allowing for consistent intake and bioavailability of essential bioactive compounds.
FAQs
How should I take Morosil®?
Take 400 mg of Morosil® daily as part of an overall weight management plan including diet and exercise.
Is Morosil® safe?
Yes, clinical studies indicate that Morosil® is generally safe and well-tolerated, with no significant safety concerns reported.
When should I take Morosil®?
There is no specific timing recommended; it should be incorporated into your daily routine.
What results can I expect from Morosil®?
Users can expect significant reductions in body mass, BMI, and waist circumference over several weeks to months.
Can I use Morosil® alone for weight loss?
Morosil® should be used as a supplementary aid alongside diet and exercise for effective weight management.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/35276783/ – This study is a randomized, double-blind, placebo-controlled trial assessing the weight loss effects of Morosil® over 6 months. Significance was noted in body mass and circumference reductions compared to the placebo group (p < 0.05).
- https://pubmed.ncbi.nlm.nih.gov/25588369/ – A clinical study focusing on the outcomes of a 12-week supplementation of Morosil® in overweight volunteers, showing significant results in weight and circumferential measures, further validating its efficacy.
- https://www.semanticscholar.org/paper/Effectiveness-of-%E2%80%9CMoro%E2%80%9D-Blood-Orange-Citrus-Osbeck-Briskey-Malfa/7d3fe25c271e58b349959009a03b6b74a433ae3c – In vitro study demonstrating the anti-adipogenic and antioxidant activities of Morosil® during adipocyte differentiation, providing mechanistic insights though limited to laboratory findings.
- https://www.researchgate.net/publication/357989005_Effectiveness_of_Moro_Blood_Orange_Citrus_sinensis_Osbeck_Rutaceae_Standardized_Extract_on_Weight_Loss_in_Overweight_but_Otherwise_Healthy_Men_and_Women-A_Randomized_Double-Blind_Placebo-Controlled_St – This publication summarizes the results of a double-blind study confirming the weight loss efficacy of Moro blood orange extract, reinforcing the safety and effectiveness observed in previous research.
- https://www.naturecity.com/blogs/p/your-guide-to-morosil-blood-orange-extract – Offers a comprehensive overview of Morosil® and its applications in dietary supplements, detailing both clinical and anecdotal outcomes relating to its use for weight management.