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Nano liquid gold

Also known as: Gold Nanoparticles, AuNPs, Nano liquid gold, Colloidal gold, Spherical gold nanoparticles

Overview

Gold nanoparticles (AuNPs), also known as nano liquid gold or colloidal gold, are synthesized particles known for their biocompatibility and unique properties. They are not naturally occurring and are created for various medical and therapeutic applications. AuNPs are characterized by their high surface area and ability to penetrate biological barriers, making them potential candidates for targeted therapy and drug delivery systems. Research suggests potential uses in treating autoimmune diseases, improving metabolic profiles, and as drug delivery platforms. However, the research is still emerging, with most evidence derived from animal models. Further human clinical trials are needed to fully establish their efficacy and safety for dietary supplement use. The quality of available evidence is currently limited, necessitating cautious interpretation of potential benefits.

Benefits

In animal studies, gold nanoparticles (AuNPs) have demonstrated potential in improving glucose and fat metabolism, suggesting a possible benefit for metabolic disorders. Specifically, AuNPs have shown promise in reducing inflammation and suppressing autoimmune responses in animal models. However, it's important to note that these benefits are primarily observed in animal studies, and human evidence is limited. Additionally, AuNPs are being explored for their potential as a drug delivery system in cancer therapy. While these findings are promising, more research, particularly human clinical trials, is necessary to confirm these benefits and determine their clinical significance.

How it works

The mechanism of action for gold nanoparticles (AuNPs) involves multiple biological pathways, including inflammation suppression and immune modulation. AuNPs can interact with various body systems, such as the immune system and metabolic pathways. While the exact molecular targets are not well-defined for dietary supplements, in medical applications, AuNPs may target specific cells or tissues. After entering the body, nanoparticles are quickly coated by plasma proteins, which affects their distribution and clearance. This interaction with plasma proteins can influence how AuNPs interact with biological systems and potentially affect their therapeutic efficacy.

Side effects

The overall safety of gold nanoparticles (AuNPs) is generally considered acceptable for short-term use, but the long-term effects are not well understood. Common side effects are not well-documented for dietary supplements containing AuNPs. Uncommon side effects, such as the potential for DNA damage, have been observed in certain contexts. Rare side effects are largely unknown due to the limited number of human studies. There is a potential for interactions with other medications, but these interactions are not well-studied. While there are no established contraindications, caution is advised for individuals with certain medical conditions. Pregnant women, children, and individuals with severe health conditions should consult healthcare providers before using AuNP supplements due to the lack of comprehensive safety data.

Dosage

Currently, there is no established minimum effective dose, optimal dosage range, or maximum safe dose for gold nanoparticles (AuNPs) in dietary supplements. Varying doses have been used in research, but no standard exists for supplement use. The timing of administration is also not established. Liquid forms may be more bioavailable than solid forms, but there is limited evidence to support this. Protein binding affects the distribution and clearance of AuNPs in the body. Due to the lack of established dosage guidelines and safety data, it is crucial to consult with a healthcare provider before using AuNP supplements.

FAQs

Are gold nanoparticles safe for human consumption?

The safety and efficacy of gold nanoparticles as a dietary supplement are not well established. Long-term safety data are lacking, and more research is needed to determine potential risks and benefits.

How should I take gold nanoparticle supplements?

There are no specific guidelines for timing and administration. It is crucial to consult with a healthcare provider before using AuNP supplements due to the lack of established dosage guidelines and safety data.

What are the expected results from taking gold nanoparticle supplements?

The expected results are variable and not well quantified. There is a belief in widespread health benefits without substantial human evidence. Consult with a healthcare provider before use.

What are the potential risks of taking gold nanoparticle supplements?

Potential risks include unknown long-term effects and potential interactions with other medications. It is important to consult with a healthcare provider before using AuNP supplements.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC6215354/ – This animal study investigated the metabolic effects of gold nanoparticles (AuNPs) in mice with pre-existing obesity. The study found that AuNPs improved glucose and fat metabolism in these mice over a 5-week period, suggesting potential benefits for metabolic disorders. However, the findings are limited by the animal model and require further validation in human studies.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10006034/ – This review discusses the potential of gold nanoparticles to suppress autoimmune inflammation. The review suggests that AuNPs can modulate the immune system and reduce inflammation, but the long-term effects and safety are still unclear. The lack of human trials limits the applicability of these findings to clinical practice.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3683956/ – This in vitro study examined the interaction of gold nanoparticles with human blood samples. The study found that AuNPs interact with plasma proteins, which affects their distribution and clearance in the body. This interaction can influence how AuNPs interact with biological systems and potentially affect their therapeutic efficacy.
https://nopren.ucsf.edu/sites/g/files/tkssra5936/f/wysiwyg/ONLY_newarticles_11Feb2022_Food.xlsx – This excel sheet contains a list of articles related to food and nutrition. It is a compilation of research articles, but it does not provide specific summaries or findings related to gold nanoparticles. Further investigation of the linked articles would be needed to extract relevant information.
https://www.science.gov/topicpages/l/lack+scientific+evidence – This page discusses the lack of scientific evidence for various topics. It serves as a general resource highlighting the importance of evidence-based research. It does not provide specific information or findings related to gold nanoparticles.