Nattokinase Powder
Also known as: Nattokinase, Subtilisin NAT
Overview
Nattokinase is an enzyme derived from natto, a traditional Japanese food made from fermented soybeans using *Bacillus subtilis* var. *natto*. It is primarily recognized for its fibrinolytic activity, meaning it can dissolve blood clots. As a dietary supplement, nattokinase is often used to support cardiovascular health, particularly for its potential to reduce blood pressure and prevent thrombosis. It is available in various forms, including capsules and powders. Research suggests that nattokinase can significantly reduce both systolic and diastolic blood pressure. While generally considered safe, individuals on anticoagulant medications should exercise caution and consult with a healthcare provider before use. Further research is needed to fully elucidate its long-term effects and optimal usage.
Benefits
Nattokinase has demonstrated potential benefits in cardiovascular health, primarily through its fibrinolytic and antihypertensive effects. Clinical studies and meta-analyses indicate that nattokinase supplementation can lead to a statistically significant reduction in both systolic and diastolic blood pressure. Specifically, a meta-analysis of six studies involving 546 participants showed a mean reduction of 3.45 mmHg in systolic blood pressure and 2.32 mmHg in diastolic blood pressure. While some studies suggest potential benefits in reducing thrombosis due to its fibrinolytic activity, more research is needed to confirm these effects in humans. These benefits may be particularly relevant for individuals with hypertension or those at risk of cardiovascular disease. However, effects on lipid profiles are mixed, with some studies showing increases in total cholesterol.
How it works
Nattokinase exerts its effects primarily through its fibrinolytic activity. It directly breaks down fibrin, a key protein involved in the formation of blood clots. This action helps to dissolve existing clots and prevent new ones from forming. Nattokinase interacts with the cardiovascular system by reducing blood clot formation and potentially lowering blood pressure. After oral ingestion, nattokinase can be detected in the blood, indicating that it is absorbed and distributed throughout the body. Peak serum levels are observed approximately 13 hours post-dose, suggesting a relatively slow absorption rate.
Side effects
Nattokinase is generally considered safe for most individuals, with no significant adverse events consistently reported in clinical studies. However, potential side effects and precautions should be considered. The most common concern is the potential for increased bleeding risk, especially in individuals taking anticoagulant medications such as warfarin or aspirin. Although specific interactions are not well-studied, the combined effect of nattokinase and anticoagulant drugs could increase the risk of bleeding. Therefore, individuals on anticoagulant therapy should consult a healthcare provider before using nattokinase. Gastrointestinal disturbances have been reported, though not well-documented. Pregnant or breastfeeding women should also consult healthcare providers due to limited safety data in these populations. It is essential to monitor for any unusual bleeding or bruising when taking nattokinase.
Dosage
The minimum effective dose of nattokinase is not well-established, but studies have used doses around 100-200 mg per day. The optimal dosage range is also unclear, with some research suggesting that higher doses may be more effective for certain outcomes. Doses up to several thousand FU (fibrinolytic units) have been used without reported adverse effects, but the maximum safe dose has not been definitively established. Consistent daily intake is typically recommended, but there are no specific timing recommendations. Nattokinase is available in capsule or powder form, and no specific form is recommended over another. Bioavailability is not well-studied, but nattokinase can be detected in the blood after oral ingestion. Individuals should consult with a healthcare provider to determine the appropriate dosage based on their individual health status and needs.
FAQs
Who should avoid taking nattokinase?
Individuals on anticoagulant medications, those with bleeding disorders, and pregnant or breastfeeding women should consult a healthcare provider before using nattokinase due to potential bleeding risks.
How long does it take to see results from nattokinase?
Some studies suggest that benefits, such as a reduction in blood pressure, can be observed within weeks to months of consistent daily intake. Individual results may vary.
Is nattokinase a substitute for blood pressure medication?
No, nattokinase is not a substitute for medical treatment for cardiovascular diseases. It should be used as a complementary therapy under the guidance of a healthcare professional.
Can nattokinase cause any side effects?
Nattokinase is generally considered safe, but potential side effects include increased bleeding risk, especially in those taking anticoagulants, and possible gastrointestinal disturbances.
How should I take nattokinase?
Consistent daily intake is recommended, but there are no specific timing recommendations. It is available in capsule or powder form. Consult with a healthcare provider for personalized advice.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/39076715/ – This systematic review and meta-analysis, encompassing 546 participants across six studies, investigated the effects of nattokinase on blood pressure and lipid profiles. The key finding was that nattokinase significantly reduces blood pressure, but its effects on lipid profiles were mixed. The study highlights the potential of nattokinase as a supplementary treatment for hypertension, while also noting the need for further research to clarify its impact on lipid metabolism.
- https://pubmed.ncbi.nlm.nih.gov/23709455/ – This pilot pharmacokinetic study with 11 healthy participants examined the absorption and bioavailability of nattokinase. The study found that nattokinase is detectable in human blood after oral ingestion, with peak levels observed approximately 13 hours post-ingestion. These findings provide initial insights into the pharmacokinetics of nattokinase, suggesting a relatively slow absorption rate.
- https://article.imrpress.com/journal/RCM/24/8/10.31083/j.rcm2408234/f4528db16e9639db9e2a042e810bc7b2.pdf – This review discusses the fibrinolytic activity and potential applications of nattokinase, focusing on its production and various uses. It highlights nattokinase's ability to break down fibrin, a key component of blood clots, and its potential role in preventing thrombosis. The review provides a comprehensive overview of nattokinase's properties and its potential applications in cardiovascular health.
- https://pubmed.ncbi.nlm.nih.gov/29219060/ – This study investigates the effects of nattokinase on blood pressure in individuals with prehypertension and hypertension. The research indicates that nattokinase supplementation can lead to a significant reduction in both systolic and diastolic blood pressure. These findings support the potential of nattokinase as a natural approach to managing blood pressure levels.
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1380727/full – This study explores the impact of nattokinase on vascular health and cognitive function in older adults. The results suggest that nattokinase may improve blood flow and cognitive performance in this population. The research highlights the potential of nattokinase as a beneficial supplement for promoting healthy aging.
