Neonatal Spleen Concentrate
Also known as: spleen aminopeptide oral solution, SAOS, neonatal spleen extract, Neonatal Spleen Concentrate
Overview
Neonatal Spleen Concentrate is a biological preparation derived from the spleen tissue of newborns. The spleen is a vital lymphoid organ involved in immune regulation. This concentrate is believed to contain peptides, amino acids, and other immune-active molecules extracted from the neonatal spleen. It is primarily investigated for its immunomodulatory effects, particularly in pediatric populations suffering from immune-related conditions like allergic rhinitis and adenoid hypertrophy. It is typically used as an adjunct to conventional treatments to potentially enhance immune function. Research on this concentrate is in its early stages, with some randomized controlled trials but a lack of large-scale systematic reviews.
Benefits
Neonatal Spleen Concentrate has shown promising benefits primarily in pediatric populations. A randomized controlled trial involving 100 children demonstrated that oral administration of spleen aminopeptide oral solution (SAOS) significantly improved nasal symptoms and reduced adenoid hypertrophy in children with allergic rhinitis when combined with standard treatment. The adenoid/nasopharynx ratio (A/N ratio) decreased, indicating a reduction in hypertrophy. These improvements were statistically significant (p < 0.05). Secondary benefits include potential immunomodulatory effects, as suggested by animal and in vitro studies, which indicate modulation of cytokine expression (e.g., IFNγ, IL23), implying a possible enhancement of immune responses. The benefits were observed after 1 to 2 months of oral administration. While the clinical trial showed significant improvements, detailed effect sizes and confidence intervals were not fully elaborated in the summary.
How it works
The precise mechanism of action for Neonatal Spleen Concentrate is not fully characterized, but it is believed to exert its effects through the modulation of immune cell activity and cytokine production. It likely influences T-cell activation and shifts cytokine profiles, potentially increasing levels of IFNγ and altering IL23 levels. The concentrate interacts with the immune system, particularly lymphoid tissues and possibly mucosal immunity within the respiratory tract. While specific molecular targets are not fully known, it is presumed to affect T-cell subsets and various cytokine signaling pathways. Given its oral administration, it is thought that the active peptides are either absorbed or act locally within the gut-associated lymphoid tissue, though detailed pharmacokinetic data are currently unavailable.
Side effects
Based on available clinical research, Neonatal Spleen Concentrate appears to have a favorable safety profile, particularly in the pediatric population studied. The randomized controlled trial reported no significant adverse effects during the 2-month treatment period in children. Common side effects have not been reported or were minimal in the clinical studies conducted. Data on uncommon or rare side effects are not available due to the limited scope of current research. No documented drug interactions have been reported; it has been used adjunctively with standard allergy medications without issues. Contraindications have not been established due to the limited research. It is important to note that safety has only been studied in children, and its safety in adults or other specific populations remains unknown.
Dosage
Optimal dosage guidelines for Neonatal Spleen Concentrate are not yet standardized or fully established. In the primary clinical trial, spleen aminopeptide oral solution (SAOS) was administered orally as an adjunct to standard therapy for a duration of 2 months. The minimum effective dose and maximum safe dose have not been definitively determined. For clinical effects to be observed, daily oral administration for at least 1 to 2 months appears to be necessary. The form used in clinical trials was an oral solution. Information regarding absorption factors or required cofactors for its efficacy is currently unknown.
FAQs
Is Neonatal Spleen Concentrate safe for children?
The available randomized controlled trial in children with allergic rhinitis reported no significant adverse effects over a 2-month treatment period, suggesting short-term safety.
How quickly does Neonatal Spleen Concentrate work?
Improvements in symptoms were observed after 1 month of treatment, with more pronounced and significant effects noted after 2 months of consistent use.
Can Neonatal Spleen Concentrate be used as a standalone treatment?
Clinical studies have used it as an adjunctive therapy alongside standard treatments; its efficacy as a monotherapy has not been proven.
Is Neonatal Spleen Concentrate widely studied?
Research on this concentrate is limited, with no large-scale meta-analyses or systematic reviews currently available, indicating a need for more extensive studies.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11543134/ – This randomized controlled trial (n=100 children) investigated the efficacy and safety of spleen aminopeptide oral solution (SAOS) for children with allergic rhinitis and adenoid hypertrophy. It found that SAOS combined with standard treatment significantly improved nasal symptoms and reduced adenoid hypertrophy compared to the control group over a 2-month period, with no reported adverse effects.
- https://www.nature.com/articles/pr2014152 – This animal study, using a fetal animal model, demonstrated immune activation in neonatal/fetal spleen in response to intraamniotic inflammation. It showed changes in cytokine profiles, including IFNγ and IL23, providing mechanistic insight into the immunomodulatory potential of spleen-derived components, though it's not directly on the supplement.
- https://academic.oup.com/immunohorizons/article/9/8/vlaf026/8206941 – This experimental study characterized immune cell populations in neonatal tissue samples, supporting the biological plausibility of immune modulatory potential from neonatal spleen components. It contributes to understanding the basic science behind how such concentrates might influence the immune system, but does not provide clinical outcomes for the supplement itself.
Supplements Containing Neonatal Spleen Concentrate
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