Neurofactor Whole Coffee Fruit Extract
Also known as: Neurofactor, Whole Coffee Fruit Extract, Coffee Cherry Extract, Coffea arabica fruit extract
Overview
Neurofactor, a proprietary extract derived from the whole coffee fruit (*Coffea arabica*), is a polyphenol-rich dietary supplement primarily studied for its cognitive-enhancing properties. The extract is characterized by its low caffeine content (approximately 0.7% in some formulations) and high concentration of polyphenols, including chlorogenic acids and other antioxidants. It is primarily marketed for its ability to increase brain-derived neurotrophic factor (BDNF), a protein crucial for neuroplasticity, learning, and memory. Research on Neurofactor is in its early to moderate stages, with several small-scale randomized controlled trials (RCTs) and pilot studies suggesting potential benefits. However, larger, long-term clinical trials are needed to confirm these findings. The quality of evidence is considered moderate, with some statistically significant results tempered by limited sample sizes and the need for replication. Neurofactor is available in various forms, including capsules and powder extracts, and is generally considered safe at studied doses.
Benefits
The primary benefit associated with Neurofactor is its ability to increase plasma BDNF levels. Studies have shown acute increases in BDNF after single doses of whole coffee fruit concentrate (WCFC), with increases averaging 137% compared to baseline (p=0.001). This suggests a potential for enhanced neuroplasticity and cognitive function. Some studies also report improvements in working memory and cognitive performance with polyphenol-rich coffee cherry extracts, including Neurofactor, indicating both acute and longer-term benefits. Additionally, the polyphenol content may offer antioxidant effects, further supporting brain health. Current research primarily focuses on healthy adults aged 25-35, and the effects in older adults or clinical populations remain to be established. While the increase in BDNF is statistically significant, more research is needed to validate direct clinical outcomes, such as improvements in cognitive test performance.
How it works
Neurofactor primarily works by stimulating the production and release of brain-derived neurotrophic factor (BDNF), a key neuroprotein essential for neuronal survival, differentiation, and synaptic plasticity. It interacts with the central nervous system by enhancing neurotrophic signaling pathways. The extract's molecular targets include BDNF and its receptor TrkB (tropomyosin receptor kinase B). Oral ingestion of Neurofactor leads to measurable increases in plasma BDNF within 60 minutes. The polyphenols present in the extract are bioavailable and may cross the blood-brain barrier or act peripherally to influence brain function, ultimately promoting cognitive enhancement.
Side effects
Neurofactor is generally considered safe at the doses studied in clinical trials. No serious adverse events have been reported. Common side effects are rare, with none reported at an incidence greater than 5% in clinical studies. Due to limited data, uncommon or rare side effects are not well-documented. No well-documented drug interactions exist, but caution is advised when combining Neurofactor with stimulants due to its low caffeine content. Contraindications are not yet established, but caution is recommended for caffeine-sensitive individuals. The safety of Neurofactor in pregnant or breastfeeding women, children, and individuals with neurological disorders has not been established, warranting caution in these populations.
Dosage
Clinical studies have used doses of whole coffee fruit concentrate powder sufficient to raise BDNF levels within 60 minutes, but the exact mg dosing varies by product and requires further research. Typically, Neurofactor is administered as capsules or powder extracts standardized for polyphenol content. While the maximum safe dose has not been definitively established, no adverse effects have been reported at the doses studied. Acute effects have been observed within 1 hour of ingestion, and repeated dosing may be necessary for sustained cognitive benefits. Polyphenol bioavailability can be influenced by the food matrix and gut microbiota, but no specific cofactors are currently identified as required for optimal absorption. More research is needed to determine optimal dosage ranges for specific cognitive outcomes.
FAQs
Is Neurofactor safe?
Current evidence suggests Neurofactor is safe at studied doses, with no significant side effects reported in clinical trials. However, long-term safety data are limited.
How quickly does it work?
BDNF levels have been shown to increase within 60 minutes after ingestion of Neurofactor, indicating a rapid onset of action.
Does it improve memory?
Some evidence supports improvements in working memory with Neurofactor supplementation, but more large-scale studies are needed to confirm these effects.
Is caffeine a concern?
Neurofactor contains a low amount of caffeine. Individuals sensitive to caffeine should monitor their tolerance when using this supplement.
Is it effective long-term?
Long-term efficacy and safety data for Neurofactor are limited. Further research is needed to determine its long-term benefits and potential risks.
Research Sources
- https://www.scirp.org/journal/paperinformation?paperid=36447 – This study investigated the modulatory effect of coffee fruit extract on plasma levels of brain-derived neurotrophic factor (BDNF) in healthy subjects. The results showed that WCFC increased plasma BDNF by 137% compared to placebo (p=0.001), suggesting a potential cognitive benefit. The study was a single-dose, placebo-controlled, within-subject RCT with 20-25 healthy adults.
- https://www.mdpi.com/2072-6643/16/14/2348 – This study examined the cognitive effects of decaffeinated coffee cherry extract in healthy adults. The findings indicated that the extract improved working memory and cognitive performance. The study was an RCT examining cognitive effects, but details on sample size and controls are limited in the summary.
- https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/modulatory-effect-of-coffee-fruit-extract-on-plasma-levels-of-brainderived-neurotrophic-factor-in-healthy-subjects/8B291E8D053143AA5A8D33B65496B034 – This research article details the modulatory effect of coffee fruit extract on plasma levels of brain-derived neurotrophic factor in healthy subjects. The study found that coffee fruit extract significantly increased BDNF levels compared to a placebo, suggesting a potential mechanism for cognitive enhancement. The study used a randomized, placebo-controlled design.
- https://www.naturecity.com/blogs/p/benefits-of-neurofactor-from-whole-coffee-fruit – This blog post discusses the benefits of Neurofactor derived from whole coffee fruit. It highlights the potential cognitive benefits and the role of BDNF in brain health. This source is not a peer-reviewed study but provides general information.
- https://www.webmd.com/diet/what-to-know-about-coffee-fruit – This WebMD article provides an overview of coffee fruit and its potential health benefits. It discusses the nutritional content and potential uses of coffee fruit as a dietary supplement. This source is not a peer-reviewed study but provides general information.