Nitrosigne
Also known as: Nitrosigine, Arginine silicate, ASI, Inositol-stabilized arginine silicate (ASI)
Overview
Nitrosigine is a patented complex formed by bonding arginine and silicate, specifically engineered to enhance the bioavailability of its key components. It is mainly utilized in dietary supplements, particularly in sports nutrition, to improve various physiological functions. Nitrosigine's primary applications include augmenting blood flow, reducing muscle damage during intense exertion, and enhancing cognitive functions such as working memory. Though it is synthesized for supplement applications, the ingredient has generated considerable interest in the context of nitric oxide production, joint health, and overall physical performance enhancement. Current research on Nitrosigine is considered emerging, showcasing moderate quality with several smaller studies but a lack of extensive large-scale trials.
Benefits
1. Cognitive Function: Nitrosigine supplementation has been shown to significantly improve working memory performance and cognitive flexibility in healthy young adults, achieving a 27% increase in immediate memory recall within 60 minutes of intake. 2. Muscle Recovery: Research indicates that it reduces muscle damage markers, such as creatine kinase, following exercise, potentially enhancing recovery. 3. Blood Flow: Nitrosigine is noted for its ability to increase blood flow, which is particularly beneficial for exercise performance, supporting both muscular and aerobic efficiency. 4. Joint Health: Preliminary studies suggest that it may help reduce inflammation related to joint health, though this primarily stems from animal research.
How it works
Nitrosigine functions by increasing nitric oxide levels in the body, which enhances blood flow and, consequently, may improve both muscular and cognitive performance. The arginine component plays a crucial role as it is a precursor for nitric oxide synthesis, while the silicate supports structural integration in tissues. Notably, the product is designed to inhibit arginase activity, preserving arginine levels and facilitating sustained nitric oxide production, thus affecting cardiovascular and neurological systems effectively.
Side effects
Overall, Nitrosigine is generally recognized as safe (GRAS) and is well-tolerated at recommended dosages. Common side effects are not well-documented; most users report no adverse reactions. Some individuals may experience mild gastrointestinal discomfort, although this is uncommon. No significant rare adverse effects have been reported in studies. Caution is advised for users on medications that affect blood flow or nitric oxide levels, and individuals with specific medical conditions should consult a healthcare provider before use. Pregnant or breastfeeding women are also recommended to seek advice from healthcare professionals regarding supplementation with Nitrosigine.
Dosage
The minimum effective dosage of Nitrosigine is typically 1,500 mg per day, which is also the optimal and most studied dose. The maximum safe dosage is consistent with this amount as it falls within GRAS limits. For best results, it is suggested to take the supplement approximately 30 to 60 minutes before exercise or cognitive tasks. Nitrosigine is available in various forms, commonly as capsules or powders, which may influence absorption rates positively due to the inositol stabilization enhancing arginine bioavailability.
FAQs
When is the best time to take Nitrosigine?
Nitrosigine is best taken about 30 minutes to 1 hour before exercise or cognitive tasks to maximize its performance-enhancing effects.
Is Nitrosigine safe to use?
Generally, Nitrosigine is considered safe, but individuals should consult a healthcare provider if they have concerns about personal health conditions or medications.
What results can I expect from using Nitrosigine?
Users can expect improvements in cognitive function and muscle recovery, particularly with enhanced working memory and reduced muscle damage following strenuous exercise.
How does Nitrosigine differ from stimulants?
Nitrosigine is not a stimulant; instead, it enhances nitric oxide levels to improve blood flow and cognitive performance without causing jitters or energy crashes typical of stimulants.
Research Sources
- https://nutrition21.com/wp-content/uploads/2020/10/Nitrosigine%C2%AE-Supplementation-Effective-in-Reducing-Inflammation-Associated-with-Joint-Health.pdf – This preclinical study highlights Nitrosigine's potential to reduce joint inflammation, establishing foundational evidence for its benefits in joint health through in vitro analyses.
- https://pubmed.ncbi.nlm.nih.gov/35580578/ – A study demonstrating the cognitive benefits of Nitrosigine, showcasing significant improvements in immediate memory for young adults in a double-blind randomized trial, though limited by sample size.
- https://blog.priceplow.com/supplement-ingredients/nitrosigine/improved-working-memory – This article reviews the cognitive enhancements associated with Nitrosigine supplementation, emphasizing the recorded benefits in working memory and mental agility observed in research.
- https://pubmed.ncbi.nlm.nih.gov/32936597/ – A double-blind placebo-controlled study that reports on the efficacy of Nitrosigine in reducing exercise-induced muscle damage markers, though it notes limitations due to a small sample size.
- https://www.journalofexerciseandnutrition.com/index.php/JEN/article/view/141 – This article discusses the effects of Nitrosigine on various performance parameters, emphasizing its role as a nitric oxide booster in muscle recovery and blood flow enhancement.