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Notopterygium

Also known as: Notopterygium, Qiang Huo, Hansenia weberbaueriana, Notopterygium incisum

Overview

Notopterygium incisum, also known as Qiang Huo, is a plant used in traditional Chinese medicine. It is recognized for its potential anti-inflammatory properties. The plant contains active metabolites such as notopterol and pterostilbene, which are being studied for their therapeutic effects. Traditionally, Notopterygium has been used to treat conditions like rheumatism and colds. Current research is exploring its potential applications in treating Obstructive Sleep Apnea Syndrome (OSAS) and COVID-19. The research on Notopterygium incisum is still emerging, with studies primarily focusing on its active metabolites and their potential therapeutic applications. Most of the available evidence is based on experimental and network analyses rather than large-scale clinical trials, indicating a need for further validation.

Benefits

Notopterygium's active metabolites, including notopterol and pterostilbene, have demonstrated potential in reducing inflammation and oxidative stress. This could be beneficial for conditions such as OSAS and COVID-19, as suggested by experimental studies. These metabolites may also exert anti-inflammatory and antioxidant effects, potentially useful in managing inflammatory diseases. However, the benefits are currently speculative and require further clinical validation, particularly for specific populations. Quantitative data on effect sizes and clinical significance are limited due to the lack of large-scale clinical trials. The time course of these potential benefits is also not well-documented and requires further research.

How it works

Notopterygium's therapeutic effects are thought to be mediated through several biological pathways. The NF-κB pathway, apoptosis, and HIF-1A pathways are implicated in the action of notopterol and pterostilbene. These compounds interact with inflammatory pathways, potentially reducing the production of pro-inflammatory cytokines such as IL-6 and TNF-α. Molecular targets associated with the therapeutic effects of Notopterygium incisum metabolites include PTGS2 and estrogen receptor alpha (ESR1). However, specific data on the absorption and bioavailability of these compounds are not readily available, limiting a complete understanding of their mechanism of action.

Side effects

Information on the safety profile of Notopterygium incisum supplements is limited, particularly in large-scale human studies. Common, uncommon, and rare side effects are not well-documented. Potential drug interactions are speculative and require further investigation. Contraindications are not clearly established. Caution is advised in pregnant women, children, and individuals with liver or kidney issues due to the lack of comprehensive safety data. Due to the limited safety information, it is crucial to consult with a healthcare professional before using Notopterygium incisum supplements to assess potential risks and benefits.

Dosage

Currently, there is insufficient evidence to establish a minimum effective dose, optimal dosage ranges, or a maximum safe dose for Notopterygium incisum. Timing considerations, form-specific recommendations, absorption factors, and required cofactors are also not established. Due to the lack of comprehensive data, it is essential to consult with a healthcare professional for personalized advice if considering the use of Notopterygium incisum. Without established dosing guidelines, users should exercise caution and prioritize safety.

FAQs

What are the practical usage concerns for Notopterygium?

Due to the lack of comprehensive safety and efficacy data, users should consult healthcare professionals before using Notopterygium. This is crucial to assess potential risks and benefits based on individual health conditions.

Is Notopterygium safe to use?

The safety of Notopterygium is not well-documented, and caution is advised. Limited research exists on its side effects and potential interactions, making it essential to seek professional medical advice.

What results can I expect from using Notopterygium?

The benefits of Notopterygium are speculative and require further research. It is not a proven treatment for any condition without further clinical validation, so expectations should be managed accordingly.

Research Sources

  • https://pmc.ncbi.nlm.nih.gov/articles/PMC10500596/ – This experimental study with network analysis suggests that pterostilbene and notopterol from Notopterygium incisum may have therapeutic effects on OSAS by modulating inflammatory pathways. The study identifies potential molecular mechanisms but lacks human clinical trials, indicating a need for further validation in clinical settings.
  • https://www.degruyter.com/document/doi/10.1515/jbcpp-2022-0028/html?lang=en – This hypothesis paper proposes that Notopterygium's metabolites may reduce cytokine storms in COVID-19 through anti-inflammatory effects. The hypothesis requires experimental validation to confirm the potential therapeutic benefits and mechanisms of action in the context of COVID-19.
  • https://pubmed.ncbi.nlm.nih.gov/35591865/ – This study highlights the importance of rigorous clinical trials to establish the efficacy and safety of herbal medicines. It emphasizes the need for comprehensive research to validate traditional uses and ensure patient safety when using herbal remedies.
  • https://onlinelibrary.wiley.com/doi/10.1155/2016/3560812 – This review discusses the challenges and opportunities in ethnopharmacology, emphasizing the importance of integrating traditional knowledge with modern scientific methods. It highlights the need for standardized protocols and rigorous clinical trials to validate the efficacy and safety of herbal medicines.
  • https://www.frontiersin.org/journals/pharmacology/sections/ethnopharmacology/articles?publication-date=01%2F01%2F2007-07%2F09%2F2023 – This collection of articles in the ethnopharmacology section of Frontiers in Pharmacology showcases diverse research on traditional medicines. The articles emphasize the importance of scientific validation and rigorous testing to ensure the safety and efficacy of herbal remedies.

Supplements Containing Notopterygium

Lustrous Hair by L.A. Naturals
80

Lustrous Hair

L.A. Naturals

Score: 80/100
The Great Invigorator Teapills Shen Tong Zhu Yu Wan by Plum Flower
68

The Great Invigorator Teapills Shen Tong Zhu Yu Wan

Plum Flower

Score: 68/100
Ligusticum Teapills Chuan Xiong Wan by Plum Flower
70

Ligusticum Teapills Chuan Xiong Wan

Plum Flower

Score: 70/100
Feverfew Head Aid 615 mg by Planetary Herbals
78

Feverfew Head Aid 615 mg

Planetary Herbals

Score: 78/100
Feverfew Head Aid 615 mg by Planetary Herbals
65

Feverfew Head Aid 615 mg

Planetary Herbals

Score: 65/100
Peach Kernel Pills by Min Shan
50

Peach Kernel Pills

Min Shan

Score: 50/100
Release the Exterior Teapills by Plum Flower
73

Release the Exterior Teapills

Plum Flower

Score: 73/100